Study on inclusion complexes of hydroxypropyl-β-cyclodextrin with tanshinone IIA
YAN Jinhong, ZHANG Cuiping, YANG Pin
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Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006, China;
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Published
05 Mar 2007
Issue Date
05 Mar 2007
Abstract
The inclusion complex formation of tanshinone IIA (Tan IIA) with hydroxypropyl-β-cyclodextrin (HPCD) was studied by using phase solubility method, and the formation constant for tanshinone IIA-HPCD- dextrin was determined. The effect of temperature on the reaction was studied through thermodynamics, and the changes inentropy, enthalpy, and free energy of the reaction were calculated. The molecular modeling provided further evidence for the formation of the inclusion complexes. Stable inclusion complex in solid state was characterized by IR spectra.
YAN Jinhong, ZHANG Cuiping, YANG Pin.
Study on inclusion complexes of hydroxypropyl-β-cyclodextrin with tanshinone IIA. Front. Chem. China, 2007, 2(1): 50‒54 https://doi.org/10.1007/s11458-007-0011-y
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