Synthesis and Fungicidal Activity of 1,3,4-Oxadiazole Substituted Acylthioureas

Abstract

A series of N 2-(5-aryl-1,3,4-oxadiazole-2-yl) actylthioureas have been synthesized from p-chlorophenoxyacetic acid, and then substituted 2-amino-5-aryl-1,3,4-oxadiazoles reacting with acylthiocyanoester, which are derived from the second step, are used. Their structures are confirmed by Infrared, ¹H nuclear magnetic resonance, and elementary analysis. From biological testing, it is found that some of these compounds have good fungicidal activity.

Keywords

2-amino-5-aryl-1,3,4-oxadiazoles, acylthiourea, synthesis, fungicidal activity