Rapid Screening and Identification of Brefeldin A in Endophytic Fungi Using HPLC-MS/MS

Fang Meijuan1, Wang Jianfeng2, Huang Yaojian3, Zhao Yufen4

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PDF(146 KB)
Front. Chem. China ›› 2006, Vol. 1 ›› Issue (1) : 15-19. DOI: 10.1007/s11458-005-0016-3

Rapid Screening and Identification of Brefeldin A in Endophytic Fungi Using HPLC-MS/MS

  • Fang Meijuan1, Wang Jianfeng2, Huang Yaojian3, Zhao Yufen4
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Abstract

Brefeldin A (BFA; C16H24O4, MW 280), a naturally occurring macrolide, exhibits diverse biological activities, such as antibiotic, antiviral, cytostatic, antimitotic, and antitumor effects. Owing to the wide activities of BFA, there is a need to develop a method for rapid identification of BFA in crude microbial extracts. In this paper, a method has been established and validated for screening and identification of individual as well as total BFA by high-performance liquid chromatography and liquid chromatography/electrospray mass spectrometry in fungal raw materials.

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Fang Meijuan, Wang Jianfeng, Huang Yaojian, Zhao Yufen. Rapid Screening and Identification of Brefeldin A in Endophytic Fungi Using HPLC-MS/MS. Front. Chem. China, 2006, 1(1): 15‒19 https://doi.org/10.1007/s11458-005-0016-3
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