Regulation of the type IIb sodium-dependent phosphate cotransporter expression in the intestine

Abstract

Phosphate (Pi) plays important roles in growth, development, bone mineralization, energy metabolism, nucleic acid synthesis, cell signaling, and acid–base regulation. The rate of intestinal absorption of Pi is a major determinant of Pi homeostasis. The type IIb sodium-dependent Pi cotransporter (NaPi-IIb) is responsible for intestinal Pi absorption. Many physiological factors regulate the rate of Pi absorption via modulating the expression of NaPi-IIb in the intestine. In this review, we summarize the role of these factors in the regulation of NaPi-IIb expression in the intestine.

Keywords

NaPi-IIb / expression / intestine / regulation

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