The effects of high-intensity training on walking speed and endurance in the subacute phase poststroke: a systematic review

Alejandro Ojeda-Manzano , Elsy Arlene Pérez-Padilla , Sergio Iván Sanguino-Suárez , Christine Cabelka , Humberto Salgado , Alexandra Borstad

Exploration of Neuroprotective Therapy ›› 2025, Vol. 5 ›› Issue (1) : 1004106

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Exploration of Neuroprotective Therapy ›› 2025, Vol. 5 ›› Issue (1) :1004106 DOI: 10.37349/ent.2025.1004106
Systematic Review
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The effects of high-intensity training on walking speed and endurance in the subacute phase poststroke: a systematic review
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Abstract

Background:High-intensity training (HIT) increases walking speed for individuals with chronic stroke. Several recent studies have examined its application for those in the subacute phase following a stroke. This systematic review examines the application of HIT in the subacute phase following a stroke.
Methods:A systematic search for studies that compared HIT (defined as 60–84% heart rate reserve or 77–93% heart rate maximum) to lower-intensity training, conventional physical therapy, placebo, or no intervention in adults 0–6 months post stroke. Randomized or quasi-randomized controlled trials, cohort studies, and case-controlled studies published in peer-reviewed journals in English were included. The primary outcome of interest was walking speed; the secondary outcome was walking endurance. Two independent evaluators performed literature selection, data extraction, and assessed study quality using the revised Cochrane risk-of-bias tool. Reporting followed PRISMA guidelines.
Results:Of 1,642 studies initially retrieved, 10 studies with a total of 677 participants were included. All experimental groups showed an average positive change in self-selected walking speed (range: 0.20–0.56 m/s). HIT resulted in statistically significant improvements in walking speed versus comparison interventions in 4 studies. Eight studies that measured walking endurance found an average increase of 60 to 197 m following HIT.
Discussion:HIT demonstrated superior outcomes in self-selected walking speed and walking endurance for individuals in the subacute phase post stroke, both immediately following intervention and at follow-up. These findings align with the clinical practice guideline (CPG) for chronic stroke patients. Further randomized clinical trials are needed to strengthen the evidence.

Keywords

High-intensity treadmill training / stroke rehabilitation / gait speed / walking distance / aerobic exercise

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Alejandro Ojeda-Manzano, Elsy Arlene Pérez-Padilla, Sergio Iván Sanguino-Suárez, Christine Cabelka, Humberto Salgado, Alexandra Borstad. The effects of high-intensity training on walking speed and endurance in the subacute phase poststroke: a systematic review. Exploration of Neuroprotective Therapy, 2025, 5 (1) : 1004106 DOI:10.37349/ent.2025.1004106

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