Celebrating the legacy of Russel J. Reiter: a pioneer in melatonin research

Keywords

Antioxidant / circadian rhythm / COVID-19 / long-COVID / neuroendocrinology / neuroprotection / oxidative stress / sleep-wake rhythm

References

[1] Hoffman RA,Reiter RJ.Pineal Gland: Influence on Gonads of Male Hamsters.Science.1965;148:1609-11.

[2] Hoffman RA,Reiter RJ.Influence of compensatory mechanisms and the pineal gland on dark-induced gonadal atrophy in male hamsters.Nature.1965;207:658-9.

[3] Lerchl A,Reiter RJ.Treatment of sleep disorders with melatonin.BMJ.2012;345:e6968.

[4] Zisapel N.New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.Br J Pharmacol.2018;175:3190-9.

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[6] Reiter RJ,Calvo JR,Karbownik M,Qi W,Tan DX.Melatonin and its relation to the immune system and inflammation.Ann N Y Acad Sci.2000;917:376-86.

[7] Reiter RJ.Mechanisms of cancer inhibition by melatonin.J Pineal Res.2004;37:213-4.

[8] Reiter RJ,Melchiorri D,Sewerynek E,Poeggeler B,Barlow-Walden L,Chuang J,et al.A review of the evidence supporting melatonin’s role as an antioxidant.J Pineal Res.1995;18:1-11.

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[11] Kilic E,Kilic U,Yulug B,Hermann DM,Reiter RJ.Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator.J Pineal Res.2004;36:171-6.

[12] Rosales-Corral SA,Acuña-Castroviejo D,Coto-Montes A,Boga JA,Manchester LC,Fuentes-Broto L,et al.Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin.J Pineal Res.2012;52:167-202.

[13] Reiter RJ,Tan DX,Pappolla MA.Melatonin relieves the neural oxidative burden that contributes to dementias.Ann N Y Acad Sci.2004;1035:179-96.

[14] Kilic U,Kilic E,Reiter RJ,Bassetti CL,Hermann DM.Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice.J Pineal Res.2005;38:67-71.

[15] Zhang R,Wang X,Ni L,Di X,Ma B,Niu S,et al.COVID-19: Melatonin as a potential adjuvant treatment.Life Sci.2020;250:117583.

[16] Tan DX,Reiter RJ.Mechanisms and clinical evidence to support melatonin’s use in severe COVID-19 patients to lower mortality.Life Sci.2022;294:120368.

[17] Loh D,Reiter RJ.Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids.Explor Neurosci.2025;4:100678.