Rethinking computational models of addiction: toward context-sensitive and psychologically grounded frameworks

Anamaria Madeliene Manu

Exploration of Neuroscience ›› 2025, Vol. 4 ›› Issue (1) : 1006119

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Exploration of Neuroscience ›› 2025, Vol. 4 ›› Issue (1) :1006119 DOI: 10.37349/en.2025.1006119
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Rethinking computational models of addiction: toward context-sensitive and psychologically grounded frameworks
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Abstract

Although addiction is a complex and contextually embedded disorder that extends beyond individual pathology and neurobiological dysfunction, prevailing computational and clinical models often reduce addiction to a chronic brain disease. While such frameworks have shaped dominant approaches to treatment and theory, they remain poorly aligned with the lived experience and behavioral phenomena of addiction, ignoring its psychological, social, and systemic dimensions. This paper examines the limitations of various disease and compulsion models both critically and in-depth, highlighting their empirical and conceptual shortcomings. In doing so, it argues for the development of context-sensitive and psychologically grounded computational models, ones capable of capturing the nuanced realities of addiction and informing more effective, personalized interventions.

Keywords

addiction / craving / reinforcement learning / dopamine / computational modeling / Bayesian inference

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Anamaria Madeliene Manu. Rethinking computational models of addiction: toward context-sensitive and psychologically grounded frameworks. Exploration of Neuroscience, 2025, 4 (1) : 1006119 DOI:10.37349/en.2025.1006119

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References

[1]

Lo TW,Yeung JWK,Tam CHL.Substance Abuse and Public Health: A Multilevel Perspective and Multiple Responses.Int J Environ Res Public Health.2020;17:2610.

[2]

World Drug Report 2023 [Internet][cited 2025 Oct 27]. Available from: https://www.unodc.org/unodc/en/data-and-analysis/world-drug-report-2023.html

[3]

Farhoudian A,Razaghi E,Hooshyari Z,Noroozi A,Pilevari A,Mokri A,et al.Barriers and Facilitators to Substance Use Disorder Treatment: An Overview of Systematic Reviews.Subst Abuse.2022;16:11782218221118462.

[4]

Campopiano von Klimo M,Nolan L,Corbin M,Farinelli L,Pytell JD,Simon C,et al.Physician Reluctance to Intervene in Addiction: A Systematic Review.JAMA Netw Open.2024;7:e2420837.

[5]

Cazalis A,Lambert L,Auriacombe M.Stigmatization of people with addiction by health professionals: Current knowledge. A scoping review.Drug Alcohol Depend Rep.2023;9:100196.

[6]

Yue H,Pena E.Addiction Psychotherapeutic CareIn: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.

[7]

Dellazizzo L,Potvin S,Giguère S,Landry C,Léveillé N,Dumais A.Meta-review on the efficacy of psychological therapies for the treatment of substance use disorders.Psychiatry Res.2023;326:115318.

[8]

Blithikioti C,Fried EI,Albanese E,Field M,Cristea IA.Reevaluating the brain disease model of addiction.Lancet Psychiatry.2025;12:469-74.

[9]

Redish AD.Addiction as a computational process gone awry.Science.2004;306:1944-7.

[10]

Valjent E,Pagès C,Hervé D,Girault JA,Caboche J.Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.Eur J Neurosci.2004;19:1826-36.

[11]

Volkow ND,Michaelides M,Baler R.The Neuroscience of Drug Reward and Addiction.Physiol Rev.2019;99:2115-40.

[12]

Heinz A,Gutwinski S,Bahr NS,Spanagel R,Di Chiara G.Does compulsion explain addiction?Addict Biol.2024;29:e13379.

[13]

Robbins TW,Banca P,Belin D.From compulsivity to compulsion: the neural basis of compulsive disorders.Nat Rev Neurosci.2024;25:313-33.

[14]

Kulkarni KR,O’Brien M,Gu X.Longing to act: Bayesian inference as a framework for craving in behavioral addiction.Addict Behav.2023;144:107752.

[15]

Wojciechowski T.Relevance of the dual systems model for predicting drug/alcohol dependence in early adulthood among previously adjudicated young adults.Drug Alcohol Depend.2021;226:108876.

[16]

Liu X,Yuan K,Lu T,Lin X,Zheng W,Xue Y,et al.Preventing incubation of drug craving to treat drug relapse: from bench to bedside.Mol Psychiatry.2023;28:1415-29.

[17]

Gu X,Filbey F.A Bayesian Observer Model of Drug Craving.JAMA Psychiatry.2017;74:419-20.

[18]

Pickard H.Addiction[cited 2025 Oct 27]. Available from: https://www.hannapickard.com/uploads/3/1/5/5/31550141/pickard_-_addiction__in_routledge_free_will_.pdf

[19]

Pickard H.Addiction and the self.Noûs.2021;55:737-61.

[20]

Haushofer J,Fehr E.On the psychology of poverty.Science.2014;344:862-7.

[21]

Hogarth L.Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology.2020;45:720-35.

[22]

Doñamayor N,Ebrahimi C,Arndt VA,Weiss F,Schlagenhauf F,Endrass T.Goal-Directed and Habitual Control in Human Substance Use: State of the Art and Future Directions.Neuropsychobiology.2022;81:403-17.

[23]

Zilverstand A,Huang AS,Alia-Klein N,Goldstein RZ.Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron.2018;98:886-903.

[24]

Slutske WS.Why is natural recovery so common for addictive disorders?Addiction.2010;105:1520-1.

[25]

De Meyer F,Zerrouk A,De Ruysscher C,Vanderplasschen W.Exploring indicators of natural recovery from alcohol and drug use problems: findings from the life in recovery survey in Flanders.Subst Abuse Treat Prev Policy.2024;19:22.

[26]

Pickard H.Responsibility without Blame for Addiction.Neuroethics.2017;10:169-80.

[27]

Li X,Kass G,Wiers CE,Shi Z.The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research.Curr Addict Rep.2024;11:797-808.

[28]

Elman I,Borsook D.Common Brain Mechanisms of Chronic Pain and Addiction.Neuron.2016;89:11-36.

[29]

Pantazis CB,Gonzalez LA,Tunstall BJ,Carmack SA,Koob GF,Vendruscolo LF.Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction.Sci Adv.2021;7:eabf0364.

[30]

Norman AB,Tsibulsky VL.The compulsion zone: a pharmacological theory of acquired cocaine self-administration.Brain Res.2006;1116:143-52.

[31]

Venniro M,Zhang M,Caprioli D,Hoots JK,Golden SA,Heins C,et al.Volitional social interaction prevents drug addiction in rat models.Nat Neurosci.2018;21:1520-9.

[32]

Grimm JW,Hope BT,Wise RA,Shaham Y.Neuroadaptation. Incubation of cocaine craving after withdrawal.Nature.2001;412:141-2.

[33]

van den Ende MWJ,Epskamp S,Lees MH,van der Maas HLJ,Wiers RW,Sloot PMA.A review of mathematical modeling of addiction regarding both (neuro-) psychological processes and the social contagion perspectives.Addict Behav.2022;127:107201.

[34]

Kato A,Shimomura K,Ognibene D,Parvaz MA,Berner LA,Morita K,et al.Computational models of behavioral addictions: State of the art and future directions.Addict Behav.2023;140:107595.

[35]

Gutkin B,Ahmed SH. editors.Computational Neuroscience of Drug Addiction.New York:Springer2012

[36]

Keiflin R,Janak PH.Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry.Neuron.2015;88:247-63.

[37]

Lucantonio F,Caprioli D,Schoenbaum G.Transition from ‘model-based’ to ‘model-free’ behavioral control in addiction: Involvement of the orbitofrontal cortex and dorsolateral striatum.Neuropharmacology.2014;76 Pt B:407-15.

[38]

Groman SM,Massi B,Mathias SR,Lee D,Taylor JR.Model-Free and Model-Based Influences in Addiction-Related Behaviors.Biol Psychiatry.2019;85:936-45.

[39]

Bustamante J,Martín CS,Laborda MA,Miguez G.An extinction cue does not necessarily prevent response recovery after extinction.Learn Motiv.2019;67:101576.

[40]

Redish AD,Jensen S,Johnson A,Kurth-Nelson Z.Reconciling reinforcement learning models with behavioral extinction and renewal: implications for addiction, relapse, and problem gambling.Psychol Rev.2007;114:784-805.

[41]

Pisupati S,Langdon A,Konova AB,Niv Y.The utility of a latent-cause framework for understanding addiction phenomena.Addict Neurosci.2024;10:100143.

[42]

Wiers RW,Verschure P.Curing the broken brain model of addiction: Neurorehabilitation from a systems perspective.Addict Behav.2021;112:106602.

[43]

Niv Y,Hitchcock P,Berwian IM,Schoen G.Chapter 12. Toward Precision Cognitive-Behavioral Therapy Via Reinforcement Learning TheoryIn: Precision Psychiatry: Using Neuroscience Insights to Inform Personally Tailored, Measurement-Based Care. 2024. pp. 199–216.

[44]

Berwian IM,Hitchock P,Pisupati S,Schoen G,Niv Y.Using computational models of learning to advance cognitive behavioral therapy.Commun Psychol.2025;3:72.

[45]

Lee SW,Shimojo S,O’Doherty JP.Neural computations underlying arbitration between model-based and model-free learning.Neuron.2014;81:687-99.

[46]

Lesaint F,Sigaud O,Flagel SB,Robinson TE,Khamassi M.Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations.PLoS Comput Biol.2014;10:e1003466.

[47]

Byrne KA,Otto AR,Pang B,Patrick CJ,Worthy DA.Substance use is associated with reduced devaluation sensitivity.Cogn Affect Behav Neurosci.2019;19:40-55.

[48]

Keramati M,Dezfouli A,Piray P.Speed/accuracy trade-off between the habitual and the goal-directed processes.PLoS Comput Biol.2011;7:e1002055.

[49]

Watson P,de Wit S,Hommel B,Wiers RW.Motivational Mechanisms and Outcome Expectancies Underlying the Approach Bias toward Addictive Substances.Front Psychol.2012;3:440.

[50]

McClure SM,Bickel WK.A dual-systems perspective on addiction: contributions from neuroimaging and cognitive training.Ann N Y Acad Sci.2014;1327:62-78.

[51]

Bickel WK,Quisenberry AJ,Moody L,Wilson AG.Therapeutic Opportunities for Self-Control Repair in Addiction and Related Disorders: Change and the Limits of Change in Trans-Disease Processes.Clin Psychol Sci.2015;3:140-53.

[52]

Pineda-Oliva D.Some Reflections on the Goal-Directed Theory of Emotion.Acta Anal.2025

[53]

Lannoy S,Billieux J,Maurage P.Beyond inhibition: a dual-process perspective to renew the exploration of binge drinking.Front Hum Neurosci.2014;8:405.

[54]

Robinson TE,Berridge KC.Review. The incentive sensitization theory of addiction: some current issues.Philos Trans R Soc Lond B Biol Sci.2008;363:3137-46.

[55]

Berridge KC,Robinson TE.Liking, wanting, and the incentive-sensitization theory of addiction.Am Psychol.2016;71:670-9.

[56]

Tindell AJ,Berridge KC,Aldridge JW.Ventral pallidal representation of pavlovian cues and reward: population and rate codes.J Neurosci.2004;24:1058-69.

[57]

Singer BF,Guptaroy B,Austin CJ,Wohl I,Lovic V,Seiler JL,et al.Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function.Eur J Neurosci.2016;43:662-70.

[58]

Locher C,Meier S,Gaab J.Psychotherapy: A World of Meanings.Front Psychol.2019;10:460.

[59]

Goldstein RZ,Volkow ND.Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.Am J Psychiatry.2002;159:1642-52.

[60]

Zilverstand AK,Goldstein RZ.Chapter 3 - Dual models of drug addiction: the impaired response inhibition and salience attribution model. In: García AV. editors.Cognition and Addiction.London, England:Academic Press2020.pp. 17–23.

[61]

Ceceli AO,Huang Y,Kronberg G,McClain N,King SG,Butelman ER,et al.The impaired Response Inhibition and Salience Attribution (iRISA) model of drug addiction: recent neuroimaging evidence and future directionsPsyArXiv [Preprint]. 2025 [cited 2025 Jul 15]. Available from: https://doi.org/10.31234/osf.io/b5wnr_v1

[62]

Knill DC,Pouget A.The Bayesian brain: the role of uncertainty in neural coding and computation.Trends Neurosci.2004;27:712-9.

[63]

Kinley I,Amlung M,Becker S.Pathologies of precision: A Bayesian account of goals, habits, and episodic foresight in addiction.Brain Cogn.2022;158:105843.

[64]

Yanagisawa H,Kawamata O,Ueda K.Modeling Emotions Associated With Novelty at Variable Uncertainty Levels: A Bayesian Approach.Front Comput Neurosci.2019;13:2.

[65]

Pezzulo G,Parr T,Friston K.Active inference as a theory of sentient behavior.Biol Psychol.2024;186:108741.

[66]

Bottemanne H.Bayesian brain theory: Computational neuroscience of belief.Neuroscience.2025;566:198-204.

[67]

Harlé KM,Yu AJ,Paulus MP.Bayesian computational markers of relapse in methamphetamine dependence.Neuroimage Clin.2019;22:101794.

[68]

Krupnik V.Bayesian Approach to Psychotherapy Integration: Strategic Modification of Priors.Front Psychol.2019;10:356.

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