Fertility and COVID-19 vaccination

Abstract

One of the most troubling developments of 2021 has been the number of fertile-age women who have been led to believe that mRNA vaccines against severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2, coronavirus disease 2019 (COVID-19)] can cause infertility via cross-reactivity of immune response. Specifically, cross-reactivity of developed antibodies to syncytin-1, a protein found in human cell fusion, placentation and recently identified in the envelope gene of a human endogenous defective retrovirus, HERV-W (see “Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis”. Nature. 2000;403:785–9. doi: 10.1038/35001608). The mechanism, evidence, and evaluation of the claim is presented concluding in a rejection due to lack of evidence.

Keywords

Fertility / messenger RNA / vaccine / coronavirus disease 2019 / syncytin-1

References

[1] Former top Pfizer scientist Michael Yeadon claims COVID vaccines may cause infertility in women [Internet]. The European Union Times; c2020 [cited 2021 Aug 24]. Available from: https://www.eutimes.net/2020/12/former-top-pfizer-scientist-michael-yeadon-claims-covid-vaccines-may-cause-infertility-in-women/

[2] Comirnaty [Internet]. European Medicines Agency; c1995- 2021 [cited 2021 Aug 24]. Available from: https://www.ema.europa.eu/en/medicines/human/EPAR/comirnaty

[3] FDA approves first COVID-19 vaccine [Internet]. Food and Drug Administration; c2021 [cited 2021 Aug 24]. Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-covid-19-vaccine

[4] Surface glycoprotein [severe acute respiratory syndrome coronavirus 2] [Internet]. National Center for Biotechnology Infirmation; c2021 [cited 2021 Aug 24]. Available from: https://www.ncbi.nlm.nih.gov/protein/YP_009724390.1

[5] Syncytin-1 precursor [ Homo sapiens] [Internet]. National Center for Biotechnology Infirmation; c2021 [cited 2021 Aug 24]. Available from: https://www.ncbi.nlm.nih.gov/protein/NP_001124397

[6] Titin [ Homo sapiens] [Internet]. National Center for Biotechnology Infirmation; c2021 [cited 2021 Aug 24]. Available from: https://www.ncbi.nlm.nih.gov/protein/CAA62188.1

[7] Basic Local Alignment Search Tool [Internet]. National Center for Biotechnology Infirmation; c2021 [cited 2021 Aug 24]. Available from: https://blast.ncbi.nlm.nih.gov/Blast.cgi

[8] Deimmunization tool [Internet]. IEBD Analysis Resource-Labs; c2021 [cited 2021 Aug 24]. Available from: http://tools.iedb.org/deimmunization/

[9] Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995; 80: 695-705.

[10] Morris RS. SARS-CoV-2 spike protein seropositivity from vaccination or infection does not cause sterility. F S Rep. 2021; 2: 253-5.

[11] Data on COVID-19 during pregnancy: birth and infant outcomes [Internet]. Centers for Disease Control and Prevention; [cited 2021 Feb 11]. Available from: https://covid.cdc.gov/covid-data-tracker/?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fcases-updates%2Fspecial-populations%2Fbirth-data-on-covid-19.html#pregnant-birth-infant

[12] Mukherjee S, Edwards DRV, Baird DD, Savitz DA, Hartmann KE. Risk of miscarriage among black women and white women in a US prospective cohort study. Am J Epidemiol. 2013; 177: 1271-8.

[13] COVID-19 vaccines and pregnancy: what you need to know if you’re pregnant, trying to get pregnant, or breastfeeding [Internet]. UChicagoMedicine; c2021 [cited 2021 Feb 11]. Available from: https://www.uchicagomedicine.org/forefront/coronavirus-disease-covid-19/mrna-covid-19-vaccine-pregnancy-breastfeeding

[14] Vaccine skeptics’ misplaced infertility concerns [Internet]. NATIONAL REVIEW; [cited 2021 Feb 11]. Available from: https://www.nationalreview.com/2021/02/vaccine-skeptics-misplaced-infertility-concerns/

[15] Gershteyn IM, Ferreira LMR. Immunodietica: a data-driven approach to investigate interactions between diet and autoimmune disorders. J Transl Autoimmun. 2019; 1: 100003.

[16] Gershteyn IM, Burov AA, Miao BY, Morais VH, Ferreira LMR. Immunodietica: interrogating the role of diet in autoimmune disease. Int Immunol. 2020; 32: 771-83.

[17] Mattar CNZ, Koh W, Seow Y, Hoon S, Venkatesh A, Dashraath P, et al. Addressing anti-syncytin antibody levels, and fertility and breastfeeding concerns, following BNT162B2 COVID-19 mRNA vaccination. medRxiv 21257686 [Preprint]. 2021 [cited 2021 Dec 7]. Available from: https://www.medrxiv.org/content/10.1101/2021.05.23.21257686v1