Glycosylated RNAs in extracellular vesicles: a new layer of RNA sorting and intercellular communication

References

[1] Yadav A,Gavande PV.Mapping GlycoRNAs on an exosomal surface.J Am Chem Soc2026;148:2739-48 PMCID:PMC12833856

[2] Kegel NB,Glatter T,Kaufmann A.Proteins are a source of glycans found in preparations of glycoRNA.Exp Mol Med2025;57:2505-16 PMCID:PMC12685969

[3] Sharma S,Yang J,Kiledjian M.Extracellular exosomal RNAs are glyco-modified.Nat Cell Biol2025;27:983-91 PMCID:PMC13175316

[4] Boyce M,Ganguli AS.Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.Proc Natl Acad Sci U S A2011;108:3141-6 PMCID:PMC3044403

[5] Flynn RA,Malaker SA.Small RNAs are modified with N-glycans and displayed on the surface of living cells.Cell2021;184:3109-24.e22 PMCID:PMC9097497

[6] Tamai K,Nakano T.Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.Biochem Biophys Res Commun2010;399:384-90

[7] Han QF,Hu KS.Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer.Mol Cancer2022;21:207 PMCID:PMC9623991

[8] Valadi H,Bossios A,Lee JJ.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.Nat Cell Biol2007;9:654-9

[9] Datta A,Lal M.Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.Cancer Lett2017;408:73-81 PMCID:PMC5628151

[10] Akella NM,Reginato MJ.Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer.BMC Biol2019;17:52 PMCID:PMC6610925

[11] Lopez-Sambrooks C,Khodier C.Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.Nat Chem Biol2016;12:1023-30 PMCID:PMC5393272

[12] Montag N,Wittmann J.The emerging role of GlycoRNAs in immune regulation and recognition.Immunol Lett2025;276:107048