Exosomal miR-302b as a novel strategy for reversing cellular senescence and promoting healthy aging

Consuelo Borrás

doi:10.20517/evcna.2025.24

Extracellular Vesicles and Circulating Nucleic Acids ›› 2025, Vol. 6 ›› Issue (2) :191 -4. DOI: 10.20517/evcna.2025.24

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Exosomal miR-302b as a novel strategy for reversing cellular senescence and promoting healthy aging

Consuelo Borrás

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Abstract

The study by Bi et al. (2025) presents “Senoreverse”, an innovative strategy that utilizes exosomal miR-302b to restore the proliferative capacity of senescent cells (SnCs), thus extending lifespan and enhancing cognitive and physical function in aging mice without the risk of tumorigenicity.

Keywords

Senescence reversal / miR-302b therapy / aging regeneration

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Consuelo Borrás. Exosomal miR-302b as a novel strategy for reversing cellular senescence and promoting healthy aging. Extracellular Vesicles and Circulating Nucleic Acids, 2025, 6(2): 191-4 DOI:10.20517/evcna.2025.24

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References

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[1]	López-Otín C,Partridge L,Kroemer G.Hallmarks of aging: an expanding universe.Cell2023;186:243-78

[2]	Bi Y,Cai Z.Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells.Cell Metab2025;37:527-41.e6

[3]	Baker DJ,Tchkonia T.Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.Nature2011;479:232-6 PMCID:PMC3468323

[4]	Wang B,Elisseeff JH.The senescence-associated secretory phenotype and its physiological and pathological implications.Nat Rev Mol Cell Biol2024;25:958-78