Selenized neural stem cell exosomes for CNS trauma repair

Lina Zhu; Kailu Guo; Xi Liu; Yanlin Feng; Cuiping Zhang

doi:10.20517/evcna.2025.156

Extracellular Vesicles and Circulating Nucleic Acids ›› 2026, Vol. 7 ›› Issue (1) :16 -9. DOI: 10.20517/evcna.2025.156

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Selenized neural stem cell exosomes for CNS trauma repair

Lina Zhu ¹^,²^,^#
, Kailu Guo ³^,⁴^,^#
, Xi Liu ³
, Yanlin Feng ⁵
, Cuiping Zhang ³

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Abstract

A recent study on Cell Reports Medicine by Wang et al. introduces a hybrid exosome platform - selenized neural stem cell-derived exosomes (SeNExo) - that couples the biological functionality of neural stem cell exosomes with the antioxidant power of ultrasmall nanoselenium. SeNExo crosses the blood-brain barrier via apolipoprotein E (APOE)-lipoprotein receptor-associated protein-1 (LRP1) interaction, scavenges reactive oxygen species, and restores glial-neuron homeostasis. It demonstrates potent therapeutic efficacy in both traumatic brain injury and spinal cord injury mouse models. This work highlights a promising direction for engineering multifunctional, cell-free nanotherapeutics for central nervous system repair.

Keywords

Exosomes / neural stem cells / selenium / traumatic brain injury / spinal cord injury / blood-brain barrier

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Lina Zhu, Kailu Guo, Xi Liu, Yanlin Feng, Cuiping Zhang. Selenized neural stem cell exosomes for CNS trauma repair. Extracellular Vesicles and Circulating Nucleic Acids, 2026, 7(1): 16-9 DOI:10.20517/evcna.2025.156

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References

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