A novel therapeutic strategy of methicillin-resistant Staphylococcus aureus

Abstract

Staphylococcus aureus is a major public health threat, largely due to its remarkable capacity to develop antimicrobial resistance. Zhang et al. recently demonstrated a highly innovative approach to eradicate chronic methicillin-resistant S. aureus infections by inducing bacterial calcification with antibody-polysialic acid conjugates targeting wall teichoic acids, while simultaneously modulating host immune responses via enhanced calprotectin expression and macrophage activation. Despite limitations, this strategy represents a promising and unconventional therapy to combat resistant S. aureus infections.

Keywords

Methicillin-resistant / taphylococcus aureus / Antimicrobial resistance / Calcification / Antibody-polysialic acid conjugate / Wall teichoic acid

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

CRediT authorship contribution statement

Ying Wang: Conceptualization, Writing - original draft, Writing - review & editing. Mengyan Xu: Visualization, Writing - review & editing. Hanne Ingmer: Conceptualization, Funding acquisition, Writing - original draft, Writing - review & editing.

Acknowledgements

This work was financially supported by Independent Research Fund, Denmark (2035-00110B) and the Novo Nordisk Foundation, Denmark (NNF22OC0077593) awarded to Hanne Ingmer. Both funders had no role in the conceptualization, analysis, the writing of the manuscript, or the decision to submit the article for publication. The graphic abstract was created with BioRender.com.

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