Research advances on the consolidated bioprocessing of lignocellulosic biomass

Abstract

Lignocellulosic biomass is an abundant and renewable bioresource for the production of biofuels and biochemical products. The classical biorefinery process for lignocellulosic degradation and conversion comprises three stages, i.e., pretreatment, enzymatic saccharification, and fermentation. However, the complicated pretreatment process, high cost of cellulase production, and insufficient production performance of fermentation strains have restricted the industrialization of biorefinery. Consolidated bioprocessing (CBP) technology combines the process of enzyme production, enzymatic saccharification, and fermentation in a single bioreactor using a specific microorganism or a consortium of microbes and represents another approach worth exploring for the production of chemicals from lignocellulosic biomass. The present review summarizes the progress made in research of CBP technology for lignocellulosic biomass conversion. In this review, different CBP strategies in lignocellulose biorefinery are reviewed, including CBP with natural lignocellulose-degrading microorganisms as the chassis, CBP with biosynthetic microorganisms as the chassis, and CBP with microbial co-culturing systems. This review provides new perspectives and insights on the utilization of low-cost feedstock lignocellulosic biomass for production of biochemicals.

Keywords

Lignocellulosic biomass / Biorefinery / Consolidated bioprocessing / Biochemicals

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

CRediT authorship contribution statement

Zhongye Li: Writing - original draft, Investigation, Writing - review & editing. Pankajkumar R. Waghmare: Writing - review & editing, Writing - original draft. Lubbert Dijkhuizen: Writing - review & editing. Xiangfeng Meng: Writing - review & editing, Funding acquisition. Weifeng Liu: Writing - review & editing, Funding acquisition.

Acknowledgments

This work was supported by grants from the National Key R&D Program of China (No. 2019YFA0905700), the National Natural Science Foundation of China (31970071), the Young Scholars Program of Shandong University, and the Major Basic Research of Shandong Provincial Natural Science Foundation (ZR2019ZD19).

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