Comparison of Ligands in Palladium-Catalyzed Electrochemical Allyl 4-Pyridinylation

Abstract

4-CN-pyridine is a widely applied 4-pyridinylation reagent for diverse transformations. Conventionally, the reaction proceeds via an open-shell radical cross-coupling pathway. Following our previous study, in this work, we report the Pd-catalyzed allyl 4-pyrinylation reaction under electrochemical conditions. The reaction proceeds via radical-polar crossover pathway in which the role of phosphine ligand in reactivity and selectivity was extensively investigated.

Keywords

Electrochemistry / Palladium / Phosphine / Pyridinylation / Allyl

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