The global research landscape and frontiers of endocrine-disrupting chemicals-induced vascular toxicity: A bibliometric and visualization analysis

Abstract

Introduction: Endocrine-disrupting chemicals (EDCs) have attracted increasing attention as potential contributors to vascular toxicity.

Objective: This study aimed to characterize the global research landscape, knowledge structure, and emerging trends in this field.

Methods: A total of 911 publications indexed in the Science Citation Index Expanded of the Web of Science Core Collection from 1997 to 2025 were analyzed using bibliometric and visualization methods to map collaboration patterns and knowledge evolution.

Results: The United States leads in both publication output and citation impact. Knowledge mapping indicates that an “exposure-mechanism-endpoint” framework is widely adopted in the literature, with “oxidative stress” appearing as a highly connected keyword linking environmental exposures and vascular outcomes. Trend analysis further suggests a shift in research focus from traditional persistent organic pollutants to emerging contaminants associated with modern lifestyles, alongside an increasing focus on early-life exposures and susceptible populations.

Conclusion: Research on EDC-related vascular toxicity is evolving toward greater emphasis on emerging contaminants, critical exposure windows, and mechanistic exploration. These trends may help inform future research directions and risk assessment strategies.

Keywords

Endocrine-disrupting chemicals / Vascular toxicity / Oxidative stress / Endothelial dysfunction / Atherosclerosis / Bibliometric analysis

References

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