Deglycaemation: a sustainable food systems strategy for developing low-glycemic foods through polyphenol enrichment, dietary fiber optimization, and starch structure modification

Ayokunle Olubode Ademosun

Exploration of Foods and Foodomics ›› 2026, Vol. 4 ›› Issue (1) : 1010190

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Exploration of Foods and Foodomics ›› 2026, Vol. 4 ›› Issue (1) :1010190 DOI: 10.37349/eff.2026.1010190
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Deglycaemation: a sustainable food systems strategy for developing low-glycemic foods through polyphenol enrichment, dietary fiber optimization, and starch structure modification
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Abstract

The global rise in diet-related non-communicable diseases has been strongly linked to the widespread consumption of highly processed, high-glycemic foods rich in refined carbohydrates and added sugars. These foods induce rapid postprandial glucose excursions that contribute to oxidative stress, insulin resistance, inflammation, and the development of metabolic disorders such as type 2 diabetes and cardiovascular disease. This review introduces deglycaemation as an integrative, systems-level framework rather than a single nutritional or technological intervention. Deglycaemation is aimed at reducing the glycemic impact of commonly consumed foods while preserving sensory quality and nutritional value. The review synthesizes evidence on key determinants of postprandial glycemia, including starch structure, food matrix properties, dietary fiber, polyphenols, fermentation, and natural sweeteners. Emerging deglycaemation strategies such as resistant starch formation, bioactive enrichment, and ingredient substitution using plant-based raw materials are highlighted for their potential to create metabolically optimized functional foods. Beyond metabolic health, the review also discusses the sustainability implications of deglycaemation through circular economy approaches and agro-industrial waste valorization. Collectively, these insights position deglycaemation as a promising multidisciplinary framework for developing healthier, sustainable food systems.

Keywords

deglycaemation / glycemic index / food reformulation / polyphenols / resistant starch / sustainability

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Ayokunle Olubode Ademosun. Deglycaemation: a sustainable food systems strategy for developing low-glycemic foods through polyphenol enrichment, dietary fiber optimization, and starch structure modification. Exploration of Foods and Foodomics, 2026, 4 (1) : 1010190 DOI:10.37349/eff.2026.1010190

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References

[1]

Ademosun AO. Removing the ‘Junk’ in foods: Developing healthy fast foods. Food Humanity. 2024; 3: 100428.

[2]

Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011; 34: 1249-57.

[3]

Caturano A, Rocco M, Tagliaferri G, Piacevole A, Nilo D, Di Lorenzo G, et al. Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications. Antioxidants. 2025; 14: 72.

[4]

WHO updates guidelines on fats and carbohydrates [Internet]. WHO; c2026 [cited 2025 Jul 15]. Available from: https://www.who.int/news/item/17—07—2023—who—updates—guidelines—on—fats—and—carbohydrates

[5]

Alamnia TT, Sargent GM, Kelly M. Dietary patterns and associations with metabolic risk factors for non—communicable disease. Sci Rep. 2023; 13: 21028.

[6]

Sheikh MY, Younus MF, Shergill A, Hasan MN. Diet and Lifestyle Interventions in Metabolic Dysfunction—Associated Fatty Liver Disease: A Comprehensive Review. Int J Mol Sci. 2025; 26: 9625.

[7]

Martínez—Díaz FM, Jiménez—Cuevas EA, Ramírez—Mejía MM, Gómez—Camacho S, Méndez—Sánchez N. The interplay of insulin resistance, glycemic variability, and metabolic dysfunction—associated steatotic liver disease. Explor Dig Dis. 2026; 5: 1005115.

[8]

Food and Agriculture Organization (FAO). The State of Food and Agriculture 2023 [Internet]. FAO; c2026 [cited 2026 Feb 12]. Available from: https://www.fao.org/agrifood—economics/publications/detail/en/c/1661488/

[9]

Ge C, Xiong J, Zhu R, Hong Z, He Y. Global burden of high sugar—sweetened beverage consumption among young adults. Diabetol Metab Syndr. 2025; 17: 259.

[10]

Mbogori T, Mucherah W. Nutrition Transition in Africa: Consequences and Opportunities. Glob J Transform Educ. 2019; 1: 5-10.

[11]

DiNicolantonio JJ, O’Keefe JH. Added Sugars Drive Insulin Resistance, Hyperinsulinemia, Hypertension, Type 2 Diabetes and Coronary Heart Disease. Mo Med. 2022; 119: 519—23.

[12]

Foster—Powell K, Holt SH, Brand—Miller JC. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002; 76: 5-56.

[13]

Mennella JA, Bobowski NK. The sweetness and bitterness of childhood: Insights from basic research on taste preferences. Physiol Behav. 2015; 152: 502-7.

[14]

Barclay AW, Augustin LSA, Brighenti F, Delport E, Henry CJ, Sievenpiper JL, et al. Dietary Glycaemic Index Labelling: A Global Perspective. Nutrients. 2021; 13: 3244.

[15]

Bhardwaj B, O’Keefe EL, O’Keefe JH. Death by Carbs: Added Sugars and Refined Carbohydrates Cause Diabetes and Cardiovascular Disease in Asian Indians. Mo Med. 2016; 113: 395-400.

[16]

Clemente—Suárez VJ, Beltrán—Velasco AI, Redondo—Flórez L, Martín—Rodríguez A, Tornero—Aguilera JF. Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review. Nutrients. 2023; 15: 2749.

[17]

Huang Y, Chen Z, Chen B, Li J, Yuan X, Li J, et al. Dietary sugar consumption and health: umbrella review. BMJ. 2023; 381: e071609.

[18]

Lang A, Kuss O, Filla T, Schlesinger S. Association between per capita sugar consumption and diabetes prevalence mediated by the body mass index: results of a global mediation analysis. Eur J Nutr. 2021; 60: 2121—9.

[19]

Willett W, Manson J, Liu S. Glycemic index, glycemic load, and risk of type 2 diabetes. Am J Clin Nutr. 2002; 76: 274S-80S.

[20]

Oboh G, Ademosun AO, Akinleye M, Omojokun OS, Boligon AA, Athayde ML. Starch composition, glycemic indices, phenolic constituents, and antioxidative and antidiabetic properties of some common tropical fruits. J Ethn Foods. 2015; 2: 64-73.

[21]

Chang—Chen KJ, Mullur R, Bernal—Mizrachi E. β—cell failure as a complication of diabetes. Rev Endocr Metab Disord. 2008; 9: 329-43.

[22]

Dholariya SJ, Orrick JA. Biochemistry, Fructose Metabolism. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.

[23]

Malik VS, Hu FB. The role of sugar—sweetened beverages in the global epidemics of obesity and chronic diseases. Nat Rev Endocrinol. 2022; 18: 205— 18.

[24]

Kosmas CE, Bousvarou MD, Kostara CE, Papakonstantinou EJ, Salamou E, Guzman E. Insulin resistance and cardiovascular disease. J Int Med Res. 2023; 51: 3000605231164548.

[25]

Yamagishi SI, Matsui T. Role of Hyperglycemia—Induced Advanced Glycation End Product (AGE) Accumulation in Atherosclerosis. Ann Vasc Dis. 2018; 11: 253—8.

[26]

Cho Y, Lee SG, Jee SH, Kim JH. Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome. Ann Lab Med. 2015; 35: 586-94.

[27]

Ma X, Nan F, Liang H, Shu P, Fan X, Song X, et al. Excessive intake of sugar: An accomplice of inflammation. Front Immunol. 2022; 13: 988481.

[28]

Macdonald IA. A review of recent evidence relating to sugars, insulin resistance and diabetes. Eur J Nutr. 2016; 55: 17-23.

[29]

Elkanawati RY, Sumiwi SA, Levita J. Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies. Drug Des Dev Ther. 2024; 18: 3337—60.

[30]

Lodge M, Dykes R, Kennedy A. Regulation of Fructose Metabolism in Nonalcoholic Fatty Liver Disease. Biomolecules. 2024; 14: 845.

[31]

Truong XT, Lee DH. Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction—Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications. Diabetes Metab J. 2025; 49: 964-86.

[32]

Ter Horst KW, Serlie MJ. Fructose Consumption, Lipogenesis, and Non—Alcoholic Fatty Liver Disease. Nutrients. 2017; 9: 981.

[33]

Roberts SB. High—glycemic Index Foods, Hunger, and Obesity: Is There a Connection? Nutr Rev. 2000; 58: 163-9.

[34]

Valicente VM, Peng CH, Pacheco KN, Lin L, Kielb EI, Dawoodani E, et al. Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported Mechanisms. Adv Nutr. 2023; 14: 718—38.

[35]

González P, Lozano P, Ros G, Solano F. Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections. Int J Mol Sci. 2023; 24: 9352.

[36]

Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. Int J Physiol Pathophysiol Pharmacol. 2019; 11: 45-63.

[37]

Pérez—Hernández AI, Catalán V, Gómez—Ambrosi J, Rodríguez A, Frühbeck G. Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion. Front Endocrinol. 2014; 5: 65.

[38]

Ruban M, Pozhidaeva E, Bolotina L, Kaprin A. The Role of Diet and Nutrition in Cancer Development and Management: From Molecular Mechanisms to Personalized Interventions. Foods. 2025; 14: 1788.

[39]

Arshad MT, Maqsood S, Altalhi R, Shamlan G, Mohamed Ahmed IA, Ikram A, et al. Role of Dietary Carbohydrates in Cognitive Function: A Review. Food Sci Nutr. 2025; 13: e70516.

[40]

Freeman LR, Haley—Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high—fat diet to the brain and cognition: A review of proposed mechanisms. Nutr Neurosci. 2014; 17: 241-51.

[41]

Romer AL, Su Kang M, Nikolova YS, Gearhardt AN, Hariri AR. Dopamine genetic risk is related to food addiction and body mass through reduced reward—related ventral striatum activity. Appetite. 2019; 133: 24-31.

[42]

Blaak EE, Antoine JM, Benton D, Björck I, Bozzetto L, Brouns F, et al. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012; 13: 923-84.

[43]

Similä ME, Valsta LM, Kontto JP, Albanes D, Virtamo J. Low—, medium— and high—glycaemic index carbohydrates and risk of type 2 diabetes in men. Br J Nutr. 2011; 105: 1258-64.

[44]

Dimitriadis GD, Maratou E, Kountouri A, Board M, Lambadiari V. Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin—Dependent and Insulin—Independent Mechanisms: An Integrative Approach. Nutrients. 2021; 13: 159.

[45]

Murillo S, Mallol A, Adot A, Juárez F, Coll A, Gastaldo I, et al. Culinary strategies to manage glycemic response in people with type 2 diabetes: A narrative review. Front Nutr. 2022; 9: 1025993.

[46]

Eleazu CO. The concept of low glycemic index and glycemic load foods as panacea for type 2 diabetes mellitus; prospects, challenges and solutions. Afr Health Sci. 2016; 16: 468-79.

[47]

Wang Y, Ral JP, Saulnier L, Kansou K. How Does Starch Structure Impact Amylolysis? Review of Current Strategies for Starch Digestibility Study. Foods. 2022; 11: 1223.

[48]

Ademosun AO, Awodire EF, Ajeigbe OF, Oboh G. Glycemic properties of noodles produced from acha (Digitaria exilis), fig leaves (Ficus exasperata) and wheat (Triticum aestivum) and effect on biochemical and hemodynamic parameters in diabetic—hypertensive rats . Food Chem Adv. 2024; 5: 100841.

[49]

Bajaj R, Singh N, Kaur A, Inouchi N. Structural, morphological, functional and digestibility properties of starches from cereals, tubers and legumes: a comparative study. J Food Sci Technol. 2018; 55: 3799-808.

[50]

Naveed H, Sultan W, Awan KA, Imtiaz A, Yaqoob S, Al—Asmari F, et al. Glycemic impact of cereal and legume—based bakery products: Implications for chronic disease management. Food Chem: X. 2024; 24: 101959.

[51]

Kaur P, Kaur H, Aggarwal R, Bains K, Mahal AK, Singla LD, et al. Analysing the Impact of Resistant Starch Formation in Basmati Rice Products: Exploring Associations with Blood Glucose and Lipid Profiles across Various Cooking and Storage Conditions In Vivo. Foods. 2024; 13: 1669.

[52]

Zhu J, Bai Y, Gilbert RG. Effects of the Molecular Structure of Starch in Foods on Human Health. Foods. 2023; 12: 2263.

[53]

Wolever TM. Effect of macronutrients on the glycemic index. Am J Clin Nutr. 2017; 106: 704—5.

[54]

Mazhar M, Zhu Y, Qin L. The Interplay of Dietary Fibers and Intestinal Microbiota Affects Type 2 Diabetes by Generating Short—Chain Fatty Acids. Foods. 2023; 12: 1023.

[55]

Sankarganesh P, Bhunia A, Ganesh Kumar A, Babu AS, Gopukumar S, Lokesh E. Short—chain fatty acids (SCFAs) in gut health: Implications for drug metabolism and therapeutics. Med Microecol. 2025; 25: 100139.

[56]

Sun L, Warren FJ, Gidley MJ. Natural products for glycaemic control: Polyphenols as inhibitors of alpha—amylase. Trends Food Sci Technol. 2019; 91: 262-73.

[57]

Kashtoh H, Baek KH. Recent Updates on Phytoconstituent Alpha—Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes. Plants. 2022; 11: 2722.

[58]

Ademosun AO, Odanye OS, Oboh G. Orange peel flavored unripe plantain noodles with low glycemic index improved antioxidant status and reduced blood glucose levels in diabetic rats. J Food Meas Charact. 2021; 15: 3742—51.

[59]

Ademosun AO. Glycemic properties of soursop—based ice cream enriched with moringa leaf powder. Foods Raw Mater. 2021; 9: 207—14.

[60]

Münte E, Hartmann P. The Role of Short—Chain Fatty Acids in Metabolic Dysfunction—Associated Steatotic Liver Disease and Other Metabolic Diseases. Biomolecules. 2025; 15: 469.

[61]

Oboh G, Rocha JBT. Antioxidant in foods: a new challenge for food processors. In: Leading Edge Antioxidants Research. Nova Science Publishers Inc; 2007. pp. 35-64.

[62]

Sun J, Chu YF, Wu X, Liu RH. Antioxidant and Antiproliferative Activities of Common Fruits. J Agric Food Chem. 2002; 50: 7449—54.

[63]

Amic D, Davidović—Amić D, Beslo D, Trinajstić N. Structure—related scavenging activity relationship of flavonoids. Croat Chem Acta. 2003; 76: 55-61.

[64]

Alía M, Horcajo C, Bravo L, Goya L. Effect of grape antioxidant dietary fiber on the total antioxidant capacity and the activity of liver antioxidant enzymes in rats. Nutr Res. 2003; 23: 1251—67.

[65]

Lindsay RC. Flavors. In: Fennema OR, editor. Food Chemistry. New York: Marcel Dekker Inc.; 1996. pp. 723—65.

[66]

Yuan YV, Bone DE, Carrington MF. Antioxidant activity of dulse (Palmaria palmata) extract evaluated in vitro . Food Chem. 2005; 91: 485-94.

[67]

Ademosun AO, Oboh G, Olasehinde TA, Adeoyo OO. From folk medicine to functional food: a review on the bioactive components and pharmacological properties of citrus peels. Orient Pharm Exp Med. 2018; 18: 9-20.

[68]

Shodehinde SA, Ademiluyi AO, Oboh G, Akindahunsi AA. Contribution of Musa paradisiaca in the inhibition of α—amylase, α—glucosidase and Angiotensin—I converting enzyme in streptozotocin induced rats . Life Sci. 2015; 133: 8-14.

[69]

Singh P, Pandey VK, Singh R, Singh K, Dash KK, Malik S. Unveiling the potential of starch—blended biodegradable polymers for substantializing the eco—friendly innovations. J Agric Food Res. 2024; 15: 101065.

[70]

Kadam SU, Tiwari BK, O’Donnell CP. Improved thermal processing for food texture modification. In: Chen J, Rosenthal A, editors. Modifying Food Texture. Woodhead Publishing; 2015. pp. 115—31.

[71]

Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes. 2016; 7: 189-200.

[72]

Krajewska A, Dziki D. Enrichment of Cookies with Fruits and Their By—Products: Chemical Composition, Antioxidant Properties, and Sensory Changes. Molecules. 2023; 28: 4005.

[73]

Cevallos—Fernández E, Beltrán—Sinchiguano E, Jácome B, Quintana T, Rivera N. Fermented Plant—Based Foods and Postbiotics for Glycemic Control—Microbial Biotransformation of Phytochemicals. Molecules. 2026; 31: 360.

[74]

Yan X, McClements DJ, Luo S, Ye J, Liu C. A review of the effects of fermentation on the structure, properties, and application of cereal starch in foods. Crit Rev Food Sci Nutr. 2024; 65: 2323—42.

[75]

Ademosun AO, Ajeigbe OF, Ademosun MT, Ogunruku OO, Oboh G. Improving gut microbiome through diet rich in dietary fibre and polyphenols: The case for orange peels. Hum Nutr Metab. 2025; 39: 200295.

[76]

Castro—Muñoz R, Correa—Delgado M, Córdova—Almeida R, Lara—Nava D, Chávez—Muñoz M, Velásquez—Chávez VF, et al. Natural sweeteners: Sources, extraction and current uses in foods and food industries. Food Chem. 2022; 370: 130991.

[77]

Qu G, Liu Y, Ma Q, Li J, Du G, Liu L, et al. Progress and Prospects of Natural Glycoside Sweetener Biosynthesis: A Review. J Agric Food Chem. 2023; 71: 15926—41.

[78]

Natural Sweeteners Market Size, Share & Industry Analysis, By Type (Honey, Molasses, Date Palm, Sugar Alcohol (Xylitol, Mannitol, Sorbitol, and Maltitol), Stevia, and Others), By Application (Food and Beverage Bakery, Confectionary, Beverages, and Others), Pharmaceuticals, and Personal care and Cosmetics), and Regional Forecast, 2026—2034 [Internet]. Fortune Business Insights; c2026 [cited 2026 Feb 12]. Available from: https://www.fortunebusinessinsights.com/industry—reports/natural—sweeteners—market—100553

[79]

Kizzie—Hayford N, Akanson J, Ampofo—Asiama J, Abano EE. Influence of Partially Substituting Wheat Flour with Tiger Nut Flour on the Physical Properties, Sensory Quality, and Consumer Acceptance of Tea, Sugar, and Butter Bread. Int J Food Sci. 2023; 2023: 7892739.

[80]

Jima BR, Abera AA, Kuyu CG. Effect of particle size on compositional, functional, pasting, and rheological properties of teff [ Eragrostis teff (zucc.) Trotter] flour . Appl Food Res. 2025; 5: 100986.

[81]

Pasmans K, Meex RCR, van Loon LJC, Blaak EE. Nutritional strategies to attenuate postprandial glycemic response. Obes Rev. 2022; 23: e13486.

[82]

Akerele GP, Adedayo BC, Oboh G, Ademosun AO, Oyeleye SI. Glycemic indices and effect of bitter leaf (Vernonia amygdalina) flavored non—alcoholic wheat beer (NAWB) on key carbohydrate metabolizing enzymes in high fat diet fed (HFD)/STZ—induced diabetic Wistar rats . J Food Biochem. 2022; 46: e14511.

[83]

Akerele GP, Adedayo BC, Oboh G, Ogunsuyi OB, Oyeleye IS. Bitter gourd flavored Non—Alcoholic Wheat Beer (NAWB) exhibited antidiabetic properties by modulating carbohydrate metabolizing enzymes and upregulates insulin and GLUT—2 mRNA expressions in High Fat Diet/Streptozotocin (HFD/STZ) induced diabetic rats. Food Prod Process Nutr. 2023; 5: 46.

[84]

Arslan M, Zareef M, Afzal M, Tahir HE, Li Z, Aalim H, et al. Innovative Non—Thermal Processing Technologies for Shelf Life Extension and Retention of Bioactive Compounds in Liquid Foods: Current Status and Future Prospects. Foods. 2025; 14: 2953.

[85]

Joshi T, Pathania G, Samandeep, Challana V, Singh A, Kaur G, et al. Mechanistic insights into fermentation induced starch biotransformation and its food functionality with nutritional relevance. Discov Food. 2026; 6: 143.

[86]

Dhiman S, Kaur S, Thakur B, Singh P, Tripathi M. Nutritional Enhancement of Plant—Based Fermented Foods: Microbial Innovations for a Sustainable Future. Fermentation. 2025; 11: 346.

[87]

Kanimozhi N, Nagalakshmi S, Sukumar M. Microbial fermentation strategies for enhancing sensory and nutritional quality of plant—based protein foods. Food Wellness. 2026; 2: 100046.

[88]

Chandel NS. Carbohydrate Metabolism. Cold Spring Harb Perspect Biol. 2021; 13: a040568.

[89]

Dong X, Chen Q, Chi W, Qiu Z, Qiu Y. A Metabolomics Study of the Effects of Eleutheroside B on Glucose and Lipid Metabolism in a Zebrafish Diabetes Model. Molecules. 2024; 29: 1545.

[90]

Zheng Y, Si Y, Li X, Jin S, Chen Y, Chen X. Sweet—Tasting Plants in regulating glucose metabolism: Mechanisms, applications and future directions. J Funct Foods. 2025; 135: 107089.

[91]

Micheli L, Lucarini E, Trallori E, Avagliano C, De Caro C, Russo R, et al. Correction: Micheli et al. Phaseolus vulgaris L. Extract: Alpha—Amylase Inhibition Against Metabolic Syndrome in Mice . Nutrients. 2019; 11: 1778.

[92]

Houghton D, Shannon OM, Chater PI, Wilcox MD, Pearson JP, Stanforth K, et al. White kidney bean extract as a nutraceutical: effects on gut microbiota, alpha—amylase inhibition, and user experiences. Gut Microbiome. 2023; 4: e8.

[93]

Koepsell H. Glucose transporters in the small intestine in health and disease. Pflüg Arch — Eur J Physiol. 2020; 472: 1207—48.

[94]

Liu D, Tang W, Han C, Nie S. Advances in Polygonatum sibiricum polysaccharides: Extraction, purification, structure, biosynthesis, and bioactivity . Front Nutr. 2022; 9: 1074671.

[95]

Kou F, Ge Y, Wang W, Mei Y, Cao L, Wei X, et al. A review of Ganoderma lucidum polysaccharides: Health benefit, structure—activity relationship, modification, and nanoparticle encapsulation . Int J Biol Macromol. 2023; 243: 125199.

[96]

Orellana—Paucar AM. Steviol Glycosides from Stevia rebaudiana: An Updated Overview of Their Sweetening Activity, Pharmacological Properties, and Safety Aspects . Molecules. 2023; 28: 1258.

[97]

Chun Y, Kim J. AMPK—mTOR Signaling and Cellular Adaptations in Hypoxia. Int J Mol Sci. 2021; 22: 9765.

[98]

Hossain U, Das AK, Ghosh S, Sil PC. An overview on the role of bioactive α—glucosidase inhibitors in ameliorating diabetic complications. Food Chem Toxicol. 2020; 145: 111738.

[99]

Jäger R, Abou Sawan S, Purpura M, Grube B, Röske Y, De Costa P, et al. Proprietary alpha—amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12—week, double—blind, placebo—controlled, randomized trial . Sci Rep. 2024; 14: 12685.

[100]

World Health Organization. Guidance on mainstreaming biodiversity for nutrition and health [Internet]. WHO; c2026 [cited 2026 Mar 4]. Available from: https://www.who.int/publications/i/item/9789240006690

[101]

Anyanwu C, Bikomeye JC, Beyer KM. The impact of environmental conditions on non—communicable diseases in sub—Saharan Africa: A scoping review of epidemiologic evidence. J Glob Health. 2024; 14: 04003.

[102]

Macheka L, Kanter R, Lawrence M, Dernini S, Naja F, Oenema S. Sustainable diets: where from and where to? J Nutr Sci. 2025; 14: e78.

[103]

Bogužas V, Skinulienė L, Butkevičienė LM, Steponavičienė V, Petrauskas E, Maršalkienė N. The Effect of Monoculture, Crop Rotation Combinations, and Continuous Bare Fallow on Soil CO2 Emissions, Earthworms, and Productivity of Winter Rye after a 50—Year Period . Plants. 2022; 11: 431.

[104]

Muhammad AS, Onyenweaku EO, Babagana K, Danjuma DS, Beba RN. Combating Malnutrition: Nutrient and Energy Composition of Locally Formulated Ready—to—Use Therapeutic Foods for Children. Int J Environ Res Public Health. 2025; 22: 1845.

[105]

Wang Y, Jian C. Sustainable plant—based ingredients as wheat flour substitutes in bread making. npj Sci Food. 2022; 6: 49.

[106]

Baptista NT, Dessalles R, Illner AK, Ville P, Ribet L, Anton PM, et al. Harnessing the power of resistant starch: a narrative review of its health impact and processing challenges. Front Nutr. 2024; 11: 1369950.

[107]

Farooq MA, Yu J. Recent Advances in Physical Processing Techniques to Enhance the Resistant Starch Content in Foods: A Review. Foods. 2024; 13: 2770.

[108]

de la Rosa—Millan J. Starch retrogradation, colloidal dynamics, and digestibility mechanisms in nixtamalized maize tortillas. J Cereal Sci. 2026; 127: 104332.

[109]

Jukanti AK, Pautong PA, Liu Q, Sreenivasulu N. Low glycemic index rice—a desired trait in starchy staples. Trends Food Sci Technol. 2020; 106: 132-49.

[110]

Özköse A. Contribution of Legume—Derived Biological Nitrogen Fixation in Reducing Greenhouse Gas Emissions Originating from Agriculture in Türkiye. Pol J Environ Stud. 2024; 33: 1337—45.

[111]

Nawaz T, Gu L, Young J, Latif R, Sher M, Xu L, et al. Harnessing nitrogen fixing plants for a bio—solar nitrogen economy. Resour Environ Sustain. 2026; 26: 100359.

[112]

Ademosun AO. Citrus peels odyssey: From the waste bin to the lab bench to the dining table. Appl Food Res. 2022; 2: 100083.

[113]

Hernández—López I, Ortiz—Solà J, Alamprese C, Barros L, Shelef O, Basheer L, et al. Valorization of Local Legumes and Nuts as Key Components of the Mediterranean Diet. Foods. 2022; 11: 3858.

[114]

Aruwajoye NN, Coetzee R. Transitioning from linear to circular systems offers sustainable solutions for smallholder agriculture in the Global South. Environ Chall. 2025; 21: 101300.

[115]

Marques C, Güneş S, Vilela A, Gomes R. Life—Cycle Assessment in Agri—Food Systems and the Wine Industry—A Circular Economy Perspective. Foods. 2025; 14: 1553.

[116]

Munonye WC, Ajonye GO, Akinloye OA. Industrial symbiosis in circular economies through policy and practice for waste to resource innovation. Discov Sustain. 2025; 6: 1371.

[117]

Doran NM. Boosting Food System Stability Through Technological Progress in Price and Supply Dynamics. Foods. 2025; 14: 3910.

[118]

AlZahabi S, Mamdouh W. Valorization of citrus processing waste into high—performance bionanomaterials: green synthesis, biomedicine, and environmental remediation. RSC Adv. 2025; 15: 36534-95.

[119]

Fu J, Liu C, Tu S, Liu H, Liu Z, He W, et al. Dietary Intervention with Resistant Starch—Rich Unripe Plantain Flour Restores Gut Microbiome—Metabolome Axis and Ameliorates Type 2 Diabetes in Rats. Foods. 2025; 14: 3996.

[120]

Roberts CK, Liu S. Effects of Glycemic Load on Metabolic Health and Type 2 Diabetes Mellitus. J Diabetes Sci Technol. 2009; 3: 697-704.

[121]

Vinoy S, Goletzke J, Rakhshandehroo M, Schweitzer L, Flourakis M, Körner A, et al. Health relevance of lowering postprandial glycaemia in the paediatric population through diet’: results from a multistakeholder workshop. Eur J Nutr. 2023; 62: 1093—107.

[122]

Wibisono DAS, Saw C, Wu T, Chau C. Advancing Industrial Food Byproduct Management: Strategies, Technologies, and Progress in Waste Reduction. Processes. 2025; 13: 84.

[123]

Boudalia S, Symeon GK, Dotas V, Gueboudji Z, Kouadri I, Sehili B, et al. The Valorization of Agrifood Byproducts and Waste to Advance the Sustainable Development Goals: Current State and New Perspectives. Sustainability. 2026; 18: 2165.

[124]

Elechi J, Nwiyi IU, Cornelius AS. Global food system transformation for resilience. IntechOpen; 2022.

[125]

Shahidi F, Athiyappan KD. Polyphenol—polysaccharide interactions: molecular mechanisms and potential applications in food systems — a comprehensive review. Food Prod Process Nutr. 2025; 7: 42.

[126]

Li H, Wang H, Dong P, Li H, Wang S, Zhang J. Comparative characterization of the metabolites of phloretin and phlorizin in rats using UHPLC—Q—Exactive Orbitrap mass spectrometer. Arab J Chem. 2024; 17: 105597.

[127]

Zhao X, Chai Z, Wang J, Hou D, Li B, Zhang L, et al. Assessment on malvidin—3—glucoside interaction with TLR4 via multi—spectroscopic analysis and molecular docking. Spectrochim Acta A: Mol Biomol Spectrosc. 2024; 318: 124460.

[128]

Plamada D, Vodnar DC. Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics. Nutrients. 2021; 14: 137.

[129]

Chetty A, Blekhman R. Multi—omic approaches for host—microbiome data integration. Gut Microbes. 2024; 16: 2297860.

[130]

Otero P, Echave J, Chamorro F, Soria—Lopez A, Cassani L, Simal—Gandara J, et al. Challenges in the Application of Circular Economy Models to Agricultural By—Products: Pesticides in Spain as a Case Study. Foods. 2023; 12: 3054.

[131]

Trumbo PR, Appleton KM, de Graaf K, Hayes JE, Baer DJ, Beauchamp GK, et al. Perspective: Measuring Sweetness in Foods, Beverages, and Diets: Toward Understanding the Role of Sweetness in Health. Adv Nutr. 2021; 12: 343-54.

[132]

Zhang H, Sun S, Ai L. Physical barrier effects of dietary fibers on lowering starch digestibility. Curr Opin Food Sci. 2022; 48: 100940.

[133]

Mahato DK, Kamle M, Pandhi S, Pandey S, Gupta A, Paul V, et al. Foodomics: A sustainable approach for the specific nutrition and diets for human health. Food Chem: X. 2024; 24: 101872.

[134]

Balkir P, Kemahlioglu K, Yucel U. Foodomics: A new approach in food quality and safety. Trends Food Sci Technol. 2021; 108: 49-57.

[135]

Kim M, Lee S, Hur J, Shin D. Metabolomics and nutrient intake reveal metabolite—nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study. Nutr J. 2025; 24: 128.

[136]

Freitas D, Lazaridou A, Duijsens D, Kotsiou K, Corbin KR, Alongi M, et al. Starch digestion: A comprehensive update on the underlying modulation mechanisms and its in vitro assessment methodologies. Trends Food Sci Technol. 2025; 159: 104969.

[137]

Mei F, Ping—Ping W, Xiong F, Chun C. Advances in starch—based binary and ternary complexes with lipids and proteins: mechanisms, digestibility, and applications in low—glycemic foods. Food Funct. 2026; 17: 5296-332.

[138]

Putignani L, Dallapiccola B. Foodomics as part of the host—microbiota—exposome interplay. J Proteom. 2016; 147: 3-20.

[139]

Camps SG, Kaur B, Lim J, Loo YT, Pang E, Ng T, et al. Improved Glycemic Control and Variability: Application of Healthy Ingredients in Asian Staples. Nutrients. 2021; 13: 3102.

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