Future trends in Food Science and Foodomics: a perspective view by the Editorial Team of Exploration of Foods and Foodomics

Elena Ibáñez , Carlo Bicchi , Francesco Capozzi , Yi Chen , Francesca Coppola , Salvatore Fanali , Sandra R. S. Ferreira , Markus Fischer , Mohsen Gavahian , Rafael Gavara , Miguel Herrero , Christos Kontogiorgis , Xianhua Liu , Luisa Mannina , Paula Martins-Lopes , Jose Antonio Mendiola , Filomena Nazzaro , Dimitrios D. Ntakoulas , Jesus Olivero-Verbel , Yolanda Picó , Charalampos Proestos , Dilip K. Rai , Luca Rastrelli , Ángel Rios , Josep Rubert , Ana Sanches Silva , Celestino Santos-Buelga , Javad Sharifi-Rad , José S. Câmara , Ivone Vaz-Moreira , Zhaowei Zhang , Alejandro Cifuentes

Exploration of Foods and Foodomics ›› 2024, Vol. 2 ›› Issue (6) : 707 -766.

PDF (6134KB)
Exploration of Foods and Foodomics ›› 2024, Vol. 2 ›› Issue (6) :707 -766. DOI: 10.37349/eff.2024.00060
Perspective
research-article
Future trends in Food Science and Foodomics: a perspective view by the Editorial Team of Exploration of Foods and Foodomics
Author information +
History +
PDF (6134KB)

Abstract

In this perspective article, several internationally recognized experts, members of the editorial team of this journal, discuss a selection of current hot topics identified in Food Science and Foodomics. The topics are comprised of the main areas of Food Science and Foodomics, namely, food safety, food authenticity, food processing, and food bioactivity. Logically, several of the discussed topics involve more than one of the mentioned main areas. Regarding food safety, the topics discussed are the use of analytical nanotechnology, nanometrology, nano-chromatography; the determination of organic contaminants based on MS and NMR; the impact of microplastics and nanoplastics on food or the contamination of foods with plant toxins. Regarding food authenticity, the paper discusses the role of MS, NMR, biosensors and the new trends in foodomics for food authentication. In terms of food processing, the work shows interesting perspectives on novel processing technologies, the effect of food processing on the gut microbiota or in the interaction among secondary metabolites and macromolecules; the development of active packaging, and the potential effects of introducing recycled plastics in food packaging; the new green extraction and encapsulation strategies of bioactive compounds from food by-products; and the anti-biofilm capacity of natural compounds/extracts/vegetal oils and essential oils. Food bioactivity and the relation between food and health includes the bioavailability and bioaccessibility of bioactive compounds; new trends and challenges in the interaction of nutraceuticals with biological systems; how food matrix impacts the bioaccessibility of nutrients and bioactive compounds; or the study of biodiversity, food and human health through one-health concept. We anticipate elaborations on these hot topics will promote further studies in Food Science and Foodomics.

Keywords

Foodomics / food & health / green chemistry / circular economy & sustainability / risk assessment / food authenticity & safety / food bioactivity / one health

Cite this article

Download citation ▾
Elena Ibáñez, Carlo Bicchi, Francesco Capozzi, Yi Chen, Francesca Coppola, Salvatore Fanali, Sandra R. S. Ferreira, Markus Fischer, Mohsen Gavahian, Rafael Gavara, Miguel Herrero, Christos Kontogiorgis, Xianhua Liu, Luisa Mannina, Paula Martins-Lopes, Jose Antonio Mendiola, Filomena Nazzaro, Dimitrios D. Ntakoulas, Jesus Olivero-Verbel, Yolanda Picó, Charalampos Proestos, Dilip K. Rai, Luca Rastrelli, Ángel Rios, Josep Rubert, Ana Sanches Silva, Celestino Santos-Buelga, Javad Sharifi-Rad, José S. Câmara, Ivone Vaz-Moreira, Zhaowei Zhang, Alejandro Cifuentes. Future trends in Food Science and Foodomics: a perspective view by the Editorial Team of Exploration of Foods and Foodomics. Exploration of Foods and Foodomics, 2024, 2 (6) : 707-766 DOI:10.37349/eff.2024.00060

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

European Commission. Commission Recommendation of 18 October 2011 on the definition of nanomaterial Text with EEA relevance. Off J Eur Communities. 2011; 275: 38-40.

[2]

Holgate ST. Exposure, uptake, distribution and toxicity of nanomaterials in humans. J Biomed Nanotechnol. 2010; 6: 1-19.

[3]

Casals E, Vázquez—Campos S, Bastús NG, Puntes V. Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanostructures in biological systems. Trends Anal Chem. 2008; 27: 672-83.

[4]

EFSA Scientific Committee More S; Bampidis V, Benford D, Bragard C, Halldorsson T, et al. Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health. EFSA J. 2021; 19: e06768.

[5]

Chen H, Zhao R, Wang B, Cai C, Zheng L, Wang H, et al. The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice. NanoImpact. 2017; 8: 80— 8.

[6]

Askri D, Ouni S, Galai S, Chovelon B, Arnaud J, Sturm N, et al. Nanoparticles in foods? A multiscale physiopathological investigation of iron oxide nanoparticle effects on rats after an acute oral exposure: Trace element biodistribution and cognitive capacities. Food Chem Toxicol. 2019; 127: 173-81.

[7]

López—Sanz S, Bernardo FJG, Martín—Doimeadios RCR, Ríos Á. Analytical metrology for nanomaterials: present achievements and future challenges. Anal Chim Acta. 2019; 1059: 1-15.

[8]

Ferraris F, Adelantado C, Raggi A, Savini S, Zougagh M, Ríos A, et al. An ICP—MS—Based analytical strategy for assessing the ban of E 171 as a food additive on the EU market. Nanomaterials. 2023; 13: 2957-70.

[9]

Bartolomé M, Villaseñor MJ, González—Serrano DJ, Hadidi M, Ríos A. Response surface methology for enzymatic ultrasound assisted sp—ICP—MS assessment of cuonps in seafood: Occurrence and bioaccumulation. Food Chem. 2025; 463: 141101.

[10]

Villamayor N, Villaseñor MJ, Ríos Á. Monitoring nanomaterials in food: a critical overview, perspectives, and challenges. Explor Foods Foodomics. 2023; 1: 43-61.

[11]

Luykx DM, Peters RJ, van Ruth SM, Bouwmeester H. A review of analytical methods for the identification and characterization of nano delivery systems in food. J Agric Food Chem. 2008; 56: 8231—47.

[12]

Tiede K, Boxall ABA, Tear SP, Lewis J, David H, Hassellov M. Detection and characterization of engineered nanoparticles in food and the environment. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008; 25: 795-821.

[13]

Silva HD, Cerqueira , Vicente AA. Nanoemulsions for food applications: development and characterization. Food Bioproc Tech. 2012; 5: 854-67.

[14]

Jin W, Xu W, Liang H, Li Y, Liu S, Li B. Nanoemulsions for food: properties, production, characterization, and application. In: Grumezescu AM, editor. Emulsions. Cambridge: Academic Press; 2016. pp. 1-36.

[15]

Du F, Zhang B, Zhou H, Yan B, Chen L. Structure elucidation of nanoparticle—bound organic molecules by1H NMR. Trends Analyt Chem. 2009; 28: 88-95.

[16]

Yamamoto T, Murakami Y, Motoyanagi J, Fukushima T, Maruyama S, Kato M. An analytical system for single nanomaterials: combination of capillary electrophoresis with Raman spectroscopy or with scanning probe microscopy for individual single—walled carbon nanotube analysis. Anal Chem. 2009; 81: 7336—41.

[17]

Kumar CSSR, editor. Raman spectroscopy for nanomaterials characterization. Heidelberg: Springer; 2012.

[18]

Kumar C, editor. UV—VIS and photoluminescence spectroscopy for nanomaterials characterization. Heidelberg: Springer; 2013.

[19]

Kumar PS, Pavithra KG, Naushad M. Characterization techniques for nanomaterials. In: Thomas S, Sakho EHM, Kalarikkal N, Oluwafemi SO, Wu J, editors. Nanomaterials for solar cell applications. Amsterdam: Elsevier; 2019. pp. 97-124.

[20]

Mozhayeva D, Engelhard C. A critical review of single particle inductively coupled plasma mass spectrometry—a step towards an ideal method for nanomaterial characterization. J Anal At Spectrom. 2020; 35: 1740-83.

[21]

Ricardo AIC, Fariñas NR, Bernardo FJG, Martín—Doimeadios RCR, Ríos Á. Screening—confirmation strategy for nanomaterials involving spectroscopic analytical techniques and its application to the control of silver nanoparticles in pastry samples. Spectrochim Acta A Mol Biomol Spectrosc. 2021; 246: 119015.

[22]

Corps Ricardo AI, Avendaño García S, Guzmán Bernardo FJ, Ríos Á, Rodríguez Martín—Doimeadios RC. Rapid assessment of silver nanoparticle migration from food containers into food simulants using a qualitative method. Food Chem. 2021; 361: 130091.

[23]

Helsper JPFG, Peters RJB, Brouwer L, Weigel S. Characterisation and quantification of liposome—type nanoparticles in a beverage matrix using hydrodynamic chromatography and MALDI—TOF mass spectrometry. Anal Bioanal Chem. 2013; 405: 1181-9.

[24]

Ramos K, Ramos L, Cámara C, Gómez—Gómez MM. Characterization and quantification of silver nanoparticles in nutraceuticals and beverages by asymmetric flow field flow fractionation coupled with inductively coupled plasma mass spectrometry. J Chromatogr A. 2014; 1371: 227-36.

[25]

Loeschner K, Navratilova J, Grombe R, Linsinger TPJ, Købler C, Mølhave K, et al. In—house validation of a method for determination of silver nanoparticles in chicken meat based on asymmetric flow field—flow fractionation and inductively coupled plasma mass spectrometric detection. Food Chem. 2015; 181: 78-84.

[26]

Pitkänen L, Striegel AM. Size—exclusion chromatography of metal nanoparticles and quantum dots. Trends Analyt Chem. 2016; 80: 311—20.

[27]

Moreno V, Zougagh M, Ríos Á. Analytical nanometrological approach for screening and confirmation of titanium dioxide nano/micro—particles in sugary samples based on Raman spectroscopy—Capillary electrophoresis. Anal Chim Acta. 2019; 1050: 169-75.

[28]

Montes C, Villaseñor MJ, Ríos Á. Analytical control of nanodelivery lipid—based systems for encapsulation of nutraceuticals: achievements and challenges. Trends Food Sci Technol. 2019; 90: 47-62.

[29]

Pinilla—Peñalver E, Soriano ML, Durán GM, Llorent EJ, Contento AM, Ríos A. Discrimination between nanocurcumin and free curcumin using graphene quantum dots as a selective fluorescence probe. Microchim Acta. 2020; 187: 446.

[30]

Montes C, Soriano ML, Villaseñor MJ, Ríos A. Design of a 3D interfacial SERS liquid sensing platform based on Au—nanobones for discrimination and quantitation of quercitin loaded nanoemulsions. Sens Actuators B. 2022; 358: 131509.

[31]

Villamayor N, Villaseñor MJ, Ríos Á. Selective dual sensing strategy for free and vitamin D3 micelles in food samples based on S,N—GQDs photoinduced electron transfer. Anal Bioanal Chem. 2024; 416: 4173-91.

[32]

Valdés MG, Valdés González AC, García Calzón JA, Díaz—García ME. Analytical nanotechnology for food analysis. Micochim Acta. 2009; 166: 1-19.

[33]

Rathee S, Ojha A. Advanced nanomaterials—based biosensors intended for food applications. Mater Lett. 2022; 313: 131752.

[34]

Manoj D, Shanmugasundaram S, Anandharamakrishnan C. Nanosensing and nanobiosensing: Concepts, methods, and applications for quality evaluation of liquid foods. Food Control. 2021; 126: 108017.

[35]

Su Z, Dou W, Liu X, Ping J, Li D, Ying Y, et al. Nano—labeled materials as detection tags for signal amplification in immunochromatographic assay. Trends Anal. Chem. 2022; 154: 116673.

[36]

Bu T, Bai F, Sun X, Tian Y, Zhang M, Zhao S, et al. An innovative prussian blue nanocubes decomposition—assisted signal amplification strategy suitable for competitive lateral flow immunoassay to sensitively detect aflatoxin B1 . Food Chem. 2021; 344: 128711.

[37]

Ji Y, Ren M, Li Y, Huang Z, Shu M, Yang H, et al. Detection of aflatoxin B₁ with immunochromatographic test strips: Enhanced signal sensitivity using gold nanoflowers. Talanta. 2015; 142: 206—12.

[38]

Faulk WP, Taylor GM. Communication to the editors: An immunocolloidal for the electron microscope. Imminochemistry. 1971; 8: 1081-4.

[39]

Kausche GA, Pfankuch E, Ruska H. Die Sichtbarmachung von pflanzlichem Virus im Übermikroskop (Visualization of plant virus in the supermicroscope). Naturwissenschaften. 1939; 27: 292—9.

[40]

Hernández—Sánchez H, Gutiérrez—López GF, editors. Food nanoscience and nanotechnology. Cham: Springer; 2015.

[41]

Chaughule RS, Lokur AS, editors. Applications of nanotechnology in microbiology. Cham: Springer; 2023.

[42]

Mattarozzi M, Suman M, Cascio C, Calestani D, Weigel S, Undas A, et al. Analytical approaches for the characterization and quantification of nanoparticles in food and beverages. Anal Bioanal Chem. 2017; 409: 63-80.

[43]

Yu X, Jiang Y, Zhang S, Wang C, Wang R, Zhang L, et al. Development of a colloidal gold immunochromatographic strip with enhanced signal for the detection of bovine parvovirus. Front Microbiol. 2023; 14: 1174737.

[44]

Chen J, Ye J, Li L, Wu Y, Liu H, Xuan Z, et al. One—step automatic sample pretreatment for rapid, simple, sensitive, and efficient determination of aflatoxin M1 in milk by immunomagnetic beads coupled to liquid chromatography—tandem mass spectrometry. Food Control. 2022; 137: 108927.

[45]

AlFaris NA, AlTamimi JA, AlOthman ZA, Qahtani SF, Wabaidur SM, Ghfar A, et al. Analysis of aflatoxins in foods retailed in Saudi Arabia using immunoaffinity column cleanup and high—performance liquid chromatography—fluorescence detection. J King Saud Univ Sci. 2020; 32: 1437—43.

[46]

Zhao Y, Yuan Y, Bai X, Liu Y, Wu G, Yang F, et al. Multi—mycotoxins analysis in liquid milk by UHPLC—Q—Exactive HRMS after magnetic solid—phase extraction based on PEGylated multi—walled carbon nanotubes. Food Chem. 2020; 305: 125429.

[47]

Huang Z, Hu S, Xiong Y, Wei H, Xu H, Duan H, et al. Application and development of superparamagnetic nanoparticles in sample pretreatment and immunochromatographic assay. Trends Anal Chem. 2019; 114: 151—70.

[48]

Liang G, Zhai H, Huang L, Tan X, Zhou Q, Yu X, et al. Synthesis of carbon quantum dots—doped dummy molecularly imprinted polymer monolithic column for selective enrichment and analysis of aflatoxin B1 in peanut. J Pharm Biomed Anal. 2018; 149: 258-64.

[49]

Pellicer—Castell E, Belenguer—Sapiña C, Amorós P, Herrero—Martínez JM, Mauri—Aucejo AR. Bimodal porous silica nanomaterials as sorbents for an efficient and inexpensive determination of aflatoxin M1 in milk and dairy products. Food Chem. 2020; 333: 127421.

[50]

Michalke B, Vinković—Vrček I. Speciation of nano and ionic form of silver with capillary electrophoresis—inductively coupled plasma mass spectrometry. J Chromatogr A. 2018; 1572: 162-71.

[51]

Ban E, Yoo YS, Song EJ. Analysis and applications of nanoparticles in capillary electrophoresis. Talanta. 2015; 141: 15-20.

[52]

Fedorenko D, Bartkevics V. Recent Applications of Nano—Liquid Chromatography in Food Safety and Environmental Monitoring: A Review. Crit Rev Anal Chem. 2023; 53: 98-122.

[53]

Skrdla PJ. Modelling sub—micron particle slip flow in liquid chromatography. Talanta. 2020; 208: 120400.

[54]

Shimizu H, Smirnova A, Mawatari K, Kitamori T. Extended—nano chromatography. J Chromatogr A. 2017; 1490: 11-20.

[55]

Takeda Y, Hayashi Y, Utamura N, Takamoto C, Kinoshita M, Yamamoto S, et al. Capillary electrochromatography using monoamine— and triamine—bonded silica nanoparticles as pseudostationary phases. J Chromatogr A. 2016; 1427: 170—6.

[56]

Crihfield CL, Holland LA. Protein Sieving with Capillary Nanogel Electrophoresis. Anal Chem. 2021; 93: 1537—43.

[57]

McClements DJ. Nanoscale Nutrient Delivery Systems for Food Applications: Improving Bioactive Dispersibility, Stability, and Bioavailability. J Food Sci. 2015; 80: N1602—11.

[58]

Hasan JA, Huq A, Tamplin ML, Siebeling RJ, Colwell RR. A novel kit for rapid detection of Vibrio cholerae O1. J Clin Microbiol. 1994; 32: 249-52.

[59]

Wang Y, Deng C, Qian S, Li H, Fu P, Zhou H, et al. An ultrasensitive lateral flow immunoassay platform for foodborne biotoxins and pathogenic bacteria based on carbon—dots embedded mesoporous silicon nanoparticles fluorescent reporter probes. Food Chem. 2023; 399: 133970.

[60]

Gupta R, Raza N, Bhardwaj SK, Vikrant K, Kim K, Bhardwaj N. Advances in nanomaterial—based electrochemical biosensors for the detection of microbial toxins, pathogenic bacteria in food matrices. J Hazard Mater. 2021; 401: 123379.

[61]

Li Y, Chen X, Yuan J, Leng Y, Lai W, Huang X, et al. Integrated gold superparticles into lateral flow immunoassays for the rapid and sensitive detection of Escherichia coli O157:H7 in milk. J Dairy Sci. 2020; 103: 6940—9.

[62]

Yahaya ML, Zakaria ND, Noordin R, Razak KA. The effect of nitrocellulose membrane pore size of lateral flow immunoassay on sensitivity for detection of Shigella sp. in milk sample. Mater Today Proc. 2019; 17: 878—83.

[63]

Shaibani PM, Jiang K, Haghighat G, Hassanpourfard M, Etayash H, Naicker S, et al. The detection of Escherichia coli (E. coli) with the pH sensitive hydrogel nanofiber—light addressable potentiometric sensor (NF—LAPS) . Sens Actuators B. 2016; 226: 176-83.

[64]

Tang Y, Li Z, Luo Q, Liu J, Wu J. Bacteria detection based on its blockage effect on silicon nanopore array. Biosens Bioelectron. 2016; 79: 715—20.

[65]

Day JB, Basavanna U. Magnetic bead based immuno—detection of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables using the Bio—Plex suspension array system. Food Microbiol. 2015; 46: 564-72.

[66]

Nógrády N, Kardos G, Bistyák A, Turcsányi I, Mészáros J, Galántai Z, et al. Prevalence and characterization of Salmonella infantis isolates originating from different points of the broiler chicken—human food chain in Hungary. Int J Food Microbiol. 2008; 127: 162—7.

[67]

Varshney M, Li Y. Interdigitated array microelectrode based impedance biosensor coupled with magnetic nanoparticle—antibody conjugates for detection of Escherichia coli O157:H7 in food samples. Biosens Bioelectron. 2007; 22: 2408—14.

[68]

Zhao G, Xing F, Deng S. A disposable amperometric enzyme immunosensor for rapid detection of Vibrio parahaemolyticus in food based on agarose/Nano—Au membrane and screen—printed electrode. Electrochem Commun. 2007; 9: 1263—8.

[69]

Mao X, Yang L, Su X, Li Y. A nanoparticle amplification based quartz crystal microbalance DNA sensor for detection of Escherichia coli O157:H7. Biosens Bioelectron. 2006; 21: 1178—85.

[70]

Yin M, Hu X, Sun Y, Xing Y, Xing G, Wang Y, et al. Broad—spectrum detection of zeranol and its analogues by a colloidal gold—based lateral flow immunochromatographic assay in milk. Food Chem. 2020; 321: 126697.

[71]

Liu S, Jiang S, Yao Z, Liu M. Aflatoxin detection technologies: recent advances and future prospects. Environ Sci Pollut Res Int. 2023; 30: 79627—53.

[72]

Chen Z, Wu H, Xiao Z, Fu H, Shen Y, Luo L, et al. Rational hapten design to produce high—quality antibodies against carbamate pesticides and development of immunochromatographic assays for simultaneous pesticide screening. J Hazard Mater. 2021; 412: 125241.

[73]

Wang S, Zhang C, Wang J, Zhang Y. Development of colloidal gold—based flow—through and lateral—flow immunoassays for the rapid detection of the insecticide carbaryl. Anal Chim Acta. 2005; 546: 161—6.

[74]

Pickova D, Ostry V, Toman J, Malir F. Aflatoxins: History, Significant Milestones, Recent Data on Their Toxicity and Ways to Mitigation. Toxins (Basel). 2021; 13: 399.

[75]

DeVries JW, Trucksess MW, Jackson LS, editors. Mycotoxins and food safety. New York: Springer; 2002.

[76]

Yadav N, Yadav SS, Chhillar AK, Rana JS. An overview of nanomaterial based biosensors for detection of Aflatoxin B1 toxicity in foods. Food Chem Toxicol. 2021; 152: 112201.

[77]

Xue Z, Zhang Y, Yu W, Zhang J, Wang J, Wan F, et al. Recent advances in aflatoxin B1 detection based on nanotechnology and nanomaterials—A review. Anal Chim Acta. 2019; 1069: 1-27.

[78]

Hamami M, Mars A, Raouafi N. Biosensor based on antifouling PEG/Gold nanoparticles composite for sensitive detection of aflatoxin M1 in milk. Microchem J. 2021; 165: 106102.

[79]

He K, Bu T, Zhao S, Bai F, Zhang M, Tian Y, et al. Well—orientation strategy for direct binding of antibodies: Development of the immunochromatographic test using the antigen modified Fe2O3 nanoprobes for sensitive detection of aflatoxin B1 . Food Chem. 2021; 364: 129583.

[80]

Chen C, Yu X, Han D, Ai J, Ke Y, Wang Z, et al. Non—CTAB synthesized gold nanorods—based immunochromatographic assay for dual color and on—site detection of aflatoxins and zearalenones in maize. Food Control. 2020; 118: 107418.

[81]

Han M, Gong L, Wang J, Zhang X, Jin Y, Zhao R, et al. An octuplex lateral flow immunoassay for rapid detection of antibiotic residues, aflatoxin M1 and melamine in milk. Sens Actuators B. 2019; 292: 94-104.

[82]

Eivazzadeh—Keihan R, Pashazadeh P, Hejazi M, de la Guardia M, Mokhtarzadeh A. Recent advances in nanomaterial—mediated bio and immune sensors for detection of aflatoxin in food products. Trends Anal Chem. 2017; 87: 112-28.

[83]

Majdinasab M, Sheikh—Zeinoddin M, Soleimanian—Zad S, Li P, Zhang Q, Li X, et al. Ultrasensitive and quantitative gold nanoparticle—based immunochromatographic assay for detection of ochratoxin A in agro—products. J Chromatogr B Analyt Technol Biomed Life Sci. 2015; 974: 147-54.

[84]

Välimaa A, Kivistö AT, Leskinen PI, Karp MT. A novel biosensor for the detection of zearalenone family mycotoxins in milk. J Microbiol Methods. 2010; 80: 44—8.

[85]

Althagafi II, Ahmed SA, El—Said WA. Colorimetric aflatoxins immunoassay by using silica nanoparticles decorated with gold nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc. 2021; 246: 118999.

[86]

Akgönüllü S, Yavuz H, Denizli A. SPR nanosensor based on molecularly imprinted polymer film with gold nanoparticles for sensitive detection of aflatoxin B1. Talanta. 2020; 219: 121219.

[87]

Bhardwaj H, Sumana G, Marquette CA. A label—free ultrasensitive microfluidic surface Plasmon resonance biosensor for Aflatoxin B1 detection using nanoparticles integrated gold chip. Food Chem. 2020; 307: 125530.

[88]

Mahmoudpour M, Ezzati Nazhad Dolatabadi J, Torbati M, Pirpour Tazehkand A, Homayouni—Rad A, de la Guardia M. Nanomaterials and new biorecognition molecules based surface plasmon resonance biosensors for mycotoxin detection. Biosens Bioelectron. 2019; 143: 111603.

[89]

Wei T, Ren P, Huang L, Ouyang Z, Wang Z, Kong X, et al. Simultaneous detection of aflatoxin B1, ochratoxin A, zearalenone and deoxynivalenol in corn and wheat using surface plasmon resonance. Food Chem. 2019; 300: 125176.

[90]

Liu C, Xu D, Dong X, Huang Q. A review: Research progress of SERS—based sensors for agricultural applications. Trends Food Sci Technol. 2022; 128: 90-101.

[91]

Chen P, Li C, Ma X, Wang Z, Zhang Y. A surface—enhanced Raman scattering aptasensor for ratiometric detection of aflatoxin B1 based on graphene oxide—Au@Ag core—shell nanoparticles complex. Food Control. 2022; 134: 108748.

[92]

Wang Q, Li S, Zhang Y, Wang S, Guo J, Wang J. A highly sensitive photothermal immunochromatographic sensor for detection of aflatoxin B1 based on Cu2—xSe—Au nanoparticles. Food Chem. 2023; 401: 134065.

[93]

Bhardwaj H, Sumana G, Marquette CA. Gold nanobipyramids integrated ultrasensitive optical and electrochemical biosensor for Aflatoxin B1 detection. Talanta. 2021; 222: 121578.

[94]

He H, Sun D, Pu H, Huang L. Bridging Fe3O4@Au nanoflowers and Au@Ag nanospheres with aptamer for ultrasensitive SERS detection of aflatoxin B1. Food Chem. 2020; 324: 126832.

[95]

Murugesan P, Moses JA. Carbon quantum dots stabilized silver nanoparticles—based colorimetric sensor for detection of pesticide residues. Mater Sci Eng B. 2024; 304: 117354.

[96]

He J, Yu L, Jiang Y, L, Han Z, Zhao X, et al. Encoding CsPbX3 perovskite quantum dots with different colors in molecularly imprinted polymers as fluorescent probes for the quantitative detection of Sudan I in food matrices. Food Chem. 2023; 402: 134499.

[97]

Li R, Wen Y, Yang L, Liu A, Wang F, He P. Dual quantum dot nanobeads—based fluorescence—linked immunosorbent assay for simultaneous detection of aflatoxin B1 and zearalenone in feedstuffs. Food Chem. 2022; 366: 130527.

[98]

Singh H, Singh S, Bhardwaj SK, Kaur G, Khatri M, Deep A, et al. Development of carbon quantum dot—based lateral flow immunoassay for sensitive detection of aflatoxin M1 in milk. Food Chem. 2022; 393: 133374.

[99]

Jia B, Liao X, Sun C, Fang L, Zhou L, Kong W. Development of a quantum dot nanobead—based fluorescent strip immunosensor for on—site detection of aflatoxin B1 in lotus seeds. Food Chem. 2021; 356: 129614.

[100]

Castro RC, Saraiva MLMFS, Santos JLM, Ribeiro DSM. Multiplexed detection using quantum dots as photoluminescent sensing elements or optical labels. Coord Chem Rev. 2021; 448: 214181.

[101]

Zhang W, Zhong H, Zhao P Shen A, Li H, Liu X. Carbon quantum dot fluorescent probes for food safety detection: Progress, opportunities and challenges. Food Control. 2022; 133: 108591.

[102]

Chmangui A, Driss MR, Touil S, Bermejo—Barrera P, Bouabdallah S, Moreda—Piñeiro A. Aflatoxins screening in non—dairy beverages by Mn—doped ZnS quantum dots—Molecularly imprinted polymer fluorescent probe. Talanta. 2019; 199: 65-71.

[103]

Pérez—Fernández B, de la Escosura—Muñiz A. Electrochemical biosensors based on nanomaterials for aflatoxins detection: A review (2015—2021). Anal Chim Acta. 2022; 1212: 339658.

[104]

Li M, Yue Q, Fang J, Wang C, Cao W, Wei Q. Au modified spindle—shaped cerium phosphate as an efficient co—reaction accelerator to amplify electrochemiluminescence signal of carbon quantum dots for ultrasensitive analysis of aflatoxin B1. Electrochim Acta. 2022; 407: 139912.

[105]

Liu D, Li W, Zhu C, Li Y, Shen X, Li L, et al. Recent progress on electrochemical biosensing of aflatoxins: A review. Trends Anal Chem. 2020; 133: 115966.

[106]

Gu Y, Wang Y, Wu X, Pan M, Hu N, Wang J, et al. Quartz crystal microbalance sensor based on covalent organic framework composite and molecularly imprinted polymer of poly(o—aminothiophenol) with gold nanoparticles for the determination of aflatoxin B1. Sens Actuators B. 2019; 291: 293-7.

[107]

Wang L, Gan X. Biomolecule—functionalized magnetic nanoparticles for flow—through quartz crystal microbalance immunoassay of aflatoxin B1. Bioprocess Biosyst Eng. 2009; 32: 109-16.

[108]

Mak AC, Osterfeld SJ, Yu H, Wang SX, Davis RW, Jejelowo OA, et al. Sensitive giant magnetoresistive—based immunoassay for multiplex mycotoxin detection. Biosens Bioelectron. 2010; 25: 1635—9.

[109]

Radoi A, Targa M, Prieto—Simon B, Marty J. Enzyme—linked immunosorbent assay (ELISA) based on superparamagnetic nanoparticles for aflatoxin M1 detection. Talanta. 2008; 77: 138-43.

[110]

Chen J, Jiang J, Liang J, Wu H, Chen L, Xu Z, et al. Bifunctional magnetic ZnCdSe/ZnS quantum dots nanocomposite—based lateral flow immunoassay for ultrasensitive detection of streptomycin and dihydrostreptomycin in milk, muscle, liver, kidney, and honey. Food Chem. 2023; 406: 135022.

[111]

Peng S, Li K, Wang Y, Li L, Cheng Y, Xu Z. Porphyrin NanoMOFs as a catalytic label in nanozyme—linked immunosorbent assay for Aflatoxin B1 detection. Anal Biochem. 2022; 655: 114829.

[112]

Malahom N, Jarujamrus P, Anutrasakda W, Siripinyanond A, Amatatongchai M, Citterio D, et al. Ag3PO4/Ag nanocomposite for selective and sensitive cyanide determination in food samples through catalytical colorimetry using a paper—based test kit. Sens Actuators B. 2022; 356: 131351.

[113]

Xu Z, Long L, Chen Y, Chen M, Cheng Y. A nanozyme—linked immunosorbent assay based on metal—organic frameworks (MOFs) for sensitive detection of aflatoxin B1 . Food Chem. 2021; 338: 128039.

[114]

Yang M, Liu G, Mehedi HM, Ouyang Q, Chen Q. A universal SERS aptasensor based on DTNB labeled GNTs/Ag core—shell nanotriangle and CS—Fe3O4 magnetic—bead trace detection of Aflatoxin B1. Anal Chim Acta. 2017; 986: 122—30.

[115]

Hu M, Hu X, Wang G, Cheng Y, Yu X, Huang X, et al. A fluorescent lateral flow immunoassay based on CdSe/CdS/ZnS quantum dots for sensitive detection of olaquindox in feedstuff. Food Chem. 2023; 419: 136025.

[116]

Borisov SM, Klimant I. Luminescent nanobeads for optical sensing and imaging of dissolved oxygen. Microchim Acta. 2009; 164: 7-15.

[117]

Moreno—González D, Pérez—Ortega P, Gilbert—López B, Molina—Díaz A, García—Reyes JF, Fernández—Alba AR. Evaluation of nanoflow liquid chromatography high resolution mass spectrometry for pesticide residue analysis in food. J Chromatogr A. 2017; 1512: 78-87.

[118]

Aydoğan C. Critical review of new advances in food and plant proteomics analyses by nano—LC/MS towards advanced foodomics. Trend Anal Chem. 2024; 176: 117759.

[119]

Chadha U, Bhardwaj P, Agarwal R, Rawat P, Agarwal R, Gupta I, et al. Recent progress and growth in biosensors technology: A critical review. J Ind Eng Chem. 2022; 109: 21-51.

[120]

Aydoğan C, Gökaltun A, Denizli A, El—Rassi Z. Organic polymer—based monolithic capillary columns and their applications in food analysis. J Sep Sci. 2019; 42: 962-79.

[121]

Aydoğan C, Beltekin B, Aslan H, Yılmaz F, Göktürk I, Denizli A, et al. Nanoscale separations: Recent achievements. J Chromatogr Open. 2022; 2: 100066.

[122]

D’Orazio G. Chiral analysis by nano—liquid chromatography. Trend Anal Chem. 2020; 125: 115832.

[123]

Fanali C, Fanali S. Chiral Separations using Miniaturized Techniques: State of the Art and Perspectives. Isr J Chem. 2016; 56: 958-67.

[124]

Fanali S. Nano—liquid chromatography applied to enantiomers separation. J Chromatogr A. 2017; 1486: 20-34.

[125]

Rocco A, Aturki Z, Fanali S. Chiral separations in food analysis. Trend Anal Chem. 2013; 52: 206-25.

[126]

Vargas Medina DA, Lanças FM. What still hinders the routine application of miniaturized liquid chromatography beyond the omics sciences? J Chromatogr Open. 2024; 6: 100149.

[127]

Vasconcelos Soares Maciel E, de Toffoli AL, Sobieski E, Domingues Nazário CE, Lanças FM. Miniaturized liquid chromatography focusing on analytical columns and mass spectrometry: A review. Anal Chim Acta. 2020; 1103: 11-31.

[128]

Aydoğan C. Chiral separation and determination of amino acid enantiomers in fruit juice by open—tubular nano liquid chromatography. Chirality. 2018; 30: 1144-9.

[129]

D’Orazio G, Cifuentes A, Fanali S. Chiral nano—liquid chromatography—mass spectrometry applied to amino acids analysis for orange juice profiling. Food Chem. 2008; 108: 1114-21.

[130]

Domínguez—Vega E, Crego AL, Lomsadze K, Chankvetadze B, Marina ML. Enantiomeric separation of FMOC—amino acids by nano—LC and CEC using a new chiral stationary phase, cellulose tris(3—chloro—4—methylphenylcarbamate). Electrophoresis. 2011; 32: 2700—7.

[131]

Roland A, Delpech S, Dagan L, Ducasse M, Cavelier F, Schneider R. Innovative analysis of 3—mercaptohexan—1—ol, 3—mercaptohexylacetate and their corresponding disulfides in wine by stable isotope dilution assay and nano—liquid chromatography tandem mass spectrometry. J Chromatogr A. 2016; 1468: 154-63.

[132]

Soto C, Ponce—Rodríguez HD, Verdú—Andrés J, Herráez—Hernández R, Campíns—Falcó P. Determination of caffeine in dietary supplements by miniaturized portable liquid chromatography. J Chromatogr A. 2022; 1664: 462770.

[133]

Martín—Ortiz A, Salcedo J, Barile D, Bunyatratchata A, Moreno FJ, Martin—García I, et al. Characterization of goat colostrum oligosaccharides by nano—liquid chromatography on chip quadrupole time—of—flight mass spectrometry and hydrophilic interaction liquid chromatography—quadrupole mass spectrometry. J Chromatogr A. 2016; 1428: 143-53.

[134]

Thompson RC, Olsen Y, Mitchell RP, Davis A, Rowland SJ, John AWG, et al. Lost at sea: where is all the plastic? Science. 2004; 304: 838.

[135]

Wang J, Liu X, Li Y, Powell T, Wang X, Wang G, et al. Microplastics as contaminants in the soil environment: A mini—review. Sci Total Environ. 2019; 691: 848-57.

[136]

Wang J, Peng C, Li H, Zhang P, Liu X. The impact of microplastic—microbe interactions on animal health and biogeochemical cycles: A mini—review. Sci Total Environ. 2021; 773: 145697.

[137]

Mamun AA, Prasetya TAE, Dewi IR, Ahmad M. Microplastics in human food chains: Food becoming a threat to health safety. Sci Total Environ. 2023; 858: 159834.

[138]

De—la—Torre GE. Microplastics: an emerging threat to food security and human health. J Food Sci Technol. 2020; 57: 1601—8.

[139]

Wang J, Li J, Liu S, Li H, Chen X, Peng C, et al. Distinct microplastic distributions in soils of different land—use types: A case study of Chinese farmlands. Environ Pollut. 2021; 269: 116199.

[140]

Peng C, Wang J, Liu X, Wang L. Differences in the Plastispheres of Biodegradable and Non—biodegradable Plastics: A Mini Review. Front Microbiol. 2022; 13: 849147.

[141]

Chen X, Wang A, Wang J, Zhang Z, Yu J, Yan Y, et al. Influences of coexisting aged polystyrene microplastics on the ecological and health risks of cadmium in soils: A leachability and oral bioaccessibility based study. J Hazard Mater. 2024; 469: 133884.

[142]

Li J, Zhang Y, Zhou Y, Liu W, Maryam B, Cui J, et al. Polystyrene nanoplastics distinctly impact cadmium uptake and toxicity in Arabidopsis thaliana. Environ Pollut. 2024; 356: 124373.

[143]

Liu S, Shi J, Wang J, Dai Y, Li H, Li J, et al. Interactions Between Microplastics and Heavy Metals in Aquatic Environments: A Review. Front Microbiol. 2021; 12: 652520.

[144]

Cherniak SL, Almuhtaram H, McKie MJ, Hermabessiere L, Yuan C, Rochman CM, et al. Conventional and biological treatment for the removal of microplastics from drinking water. Chemosphere. 2022; 288: 132587.

[145]

Li H, Chen H, Wang J, Li J, Liu S, Tu J, et al. Influence of Microplastics on the Growth and the Intestinal Microbiota Composition of Brine Shrimp. Front Microbiol. 2021; 12: 717272.

[146]

Li J, Li Y, Maryam B, Chen X, Zong Y, Tu J, et al. Microplastic aging alters the adsorption—desorption behaviors of sulfamethoxazole in marine animals: A study in simulated biological liquids. Mar Pollut Bull. 2023; 195: 115473.

[147]

Bayo J, Olmos S, López—Castellanos J. Microplastics in an urban wastewater treatment plant: The influence of physicochemical parameters and environmental factors. Chemosphere. 2020; 238: 124593.

[148]

Yi Z, Zhang Z, Chen G, Rengel Z, Sun H. Microplastics have rice cultivar—dependent impacts on grain yield and quality, and nitrogenous gas losses from paddy, but not on soil properties. J Hazard Mater. 2023; 446: 130672.

[149]

Rong S, Wang S, Liu H, Li Y, Huang J, Wang W, et al. Evidence for the transportation of aggregated microplastics in the symplast pathway of oilseed rape roots and their impact on plant growth. Sci Total Environ. 2024; 912: 169419.

[150]

Aydın RB, Yozukmaz A, Şener İ, Temiz F, Giannetto D. Occurrence of Microplastics in Most Consumed Fruits and Vegetables from Turkey and Public Risk Assessment for Consumers. Life. 2023; 13: 1686.

[151]

Maurizi L, Iordachescu L, Kirstein IV, Nielsen AH, Vollertsen J. It matters how we measure—Quantification of microplastics in drinking water by μFTIR and μRaman. Heliyon. 2023; 9: e20119.

[152]

Makhdoumi P, Pirsaheb M, Amin AA, Kianpour S, Hossini H. Microplastic Pollution in Table Salt and Sugar: Occurrence, Qualification and Quantification and Risk Assessment. J Food Compos Anal. 2023; 119: 105261.

[153]

Xu J, Rodríguez—Torres R, Rist S, Nielsen TG, Hartmann NB, Brun P, et al. Unpalatable Plastic: Efficient Taste Discrimination of Microplastics in Planktonic Copepods. Environ Sci Technol. 2022; 56: 6455-65.

[154]

Wang X, Zheng K, Wang Y, Hou X, He Y, Wang Z, et al. Microplastics and viruses in the aquatic environment: a mini review. Front Microbiol. 2024; 15: 1433724.

[155]

Xiong F, Liu J, Xu K, Huang J, Wang D, Li F, et al. Microplastics induce neurotoxicity in aquatic animals at environmentally realistic concentrations: A meta—analysis. Environ Pollut. 2023; 318: 120939.

[156]

Wang J, Yang Y, Shi Y, Wei L, Gao L, Liu M. Oxidized/unmodified—polyethylene microplastics neurotoxicity in mice: Perspective from microbiota—gut—brain axis. Environ Int. 2024; 185: 108523.

[157]

Yu Y, Xie D, Yang Y, Tan S, Li H, Dang Y, et al. Carboxyl—modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans. J Hazard Mater. 2023; 445: 130543.

[158]

Herberz T, Barlow CY, Finkbeiner M. Sustainability Assessment of a Single—Use Plastics Ban. Sustainability. 2020; 12: 3746.

[159]

Liu C, Liu C. Exploring Plastic—Management Policy in China: Status, Challenges and Policy Insights. Sustainability. 2023; 15: 9087.

[160]

Liu C, Luan P, Li Q, Cheng Z, Sun X, Cao D, et al. Biodegradable, Hygienic, and Compostable Tableware from Hybrid Sugarcane and Bamboo Fibers as Plastic Alternative. Matter. 2020; 3: 2066-79.

[161]

Rai R, Ranjan R, Kant C, Dhar P. Biodegradable, Eco—Friendly, and Hydrophobic Drinking Straws Based on Delignified Phosphorylated Bamboo—Gelatin Composites. Chem Eng J. 2023; 471: 144047.

[162]

Karaca M, Erbaş O. Solanine Poisoning: Effects, Risks, and Management Strategies. J Exp Basic Med Sci. 2024; 5: 189-93.

[163]

Liu Y, Hu H, Yang R, Zhu Z, Cheng K. Current Advances in the Biosynthesis, Metabolism, and Transcriptional Regulation of α—Tomatine in Tomato. Plants (Basel). 2023; 12: 3289.

[164]

Dey P, Kundu A, Kumar A, Gupta M, Lee BM, Bhakta T, et al. Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids). In: Recent Advances in Natural Products Analysis. Elsevier. 2020. pp. 505-67.

[165]

Kohnen—Johannsen KL, Kayser O. Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production. Molecules. 2019; 24: 796.

[166]

Mateus ARS, Crisafulli C, Barros SC, Pena A, Silva AS. Development and validation of an analytical method based on QuEChERS followed by UHPLC—ToF—MS for the determination of tropane alkaloids in buckwheat (Fagopyrum esculentum L.) and buckwheat products. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2024; 41: 648—63.

[167]

Mateus ARS, Crisafulli C, Vilhena M, Barros SC, Pena A, Silva AS. The Bright and Dark Sides of Herbal Infusions: Assessment of Antioxidant Capacity and Determination of Tropane Alkaloids. Toxins (Basel). 2023; 15: 245.

[168]

Tábuas B, Barros SC, Diogo C, Cavaleiro C, Silva AS. Pyrrolizidine Alkaloids in Foods, Herbal Drugs, and Food Supplements: Chemistry, Metabolism, Toxicological Significance, Analytical Methods, Occurrence, and Challenges for Future. Toxins (Basel). 2024; 16: 79.

[169]

European Commission. Commission Regulation (EU) 2023/915 on maximum levels for certain contaminants in food and repealing Regulation (EC) No 1881/2006. Off J Eur Communities. 2023; 119: 103-57.

[170]

Park H, Chung H, Choi S, Bahn Y, Son J. Evaluation of exposure to cyanogenic glycosides and potential hydrogen cyanide release in commercially available foods among the Korean population. Food Chem. 2024; 456: 139872.

[171]

Katoch R, Tripathi A. Research advances and prospects of legume lectins. J Biosci. 2021; 46: 104.

[172]

Misiewicz B, Mencer D, Terzaghi W, VanWert AL. Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion. Molecules. 2023; 28: 3206.

[173]

Mateus ARS, Barros S, Pena A, Silva AS. Development and Validation of QuEChERS Followed by UHPLC—ToF—MS Method for Determination of Multi—Mycotoxins in Pistachio Nuts. Molecules. 2021; 26: 5754.

[174]

Silva AS, Brites C, Pouca AV, Barbosa J, Freitas A. UHPLC—ToF—MS method for determination of multi—mycotoxins in maize: Development and validation. Curr Res Food Sci. 2019; 1: 1-7.

[175]

Urugo MM, Tringo TT. Naturally Occurring Plant Food Toxicants and the Role of Food Processing Methods in Their Detoxification. Int J Food Sci. 2023; 2023: 9947841.

[176]

Samtiya M, Aluko RE, Dhewa T. Plant food anti—nutritional factors and their reduction strategies: an overview. Food Prod Process Nutr. 2020; 2: 6.

[177]

Kaiser N, Douches D, Dhingra A, Glenn KC, Herzig PR, Stowe EC, et al. The role of conventional plant breeding in ensuring safe levels of naturally occurring toxins in food crops. Trends Food Sci Technol. 2020; 100: 51-66.

[178]

Abia WA, Montgomery H, Nugent AP, Elliott CT. Tropane alkaloid contamination of agricultural commodities and food products in relation to consumer health: Learnings from the 2019 Uganda food aid outbreak. Compr Rev Food Sci Food Saf. 2021; 20: 501-25.

[179]

Edwards SG. Influence of agricultural practices on fusarium infection of cereals and subsequent contamination of grain by trichothecene mycotoxins. Toxicol Lett. 2004; 153: 29-35.

[180]

Li X, Liu Y, Yin Y, Wang P, Su X. Occurrence of some legacy and emerging contaminants in feed and food and their ranking priorities for human exposure. Chemosphere. 2023; 321: 138117.

[181]

Picó Y, Campo J. An Overview of the State—of—the—Art: Mass Spectrometry in Food and Environment. In: Mass Spectrometry in Food and Environmental Chemistry. Cham: Springer; 2023. pp. 1-23.

[182]

Sun Q, Dong Y, Wen X, Zhang X, Hou S, Zhao W, et al. A review on recent advances in mass spectrometry analysis of harmful contaminants in food. Front Nutr. 2023; 10: 1244459.

[183]

Nolvachai Y, Amaral MSS, Marriott PJ. Foods and Contaminants Analysis Using Multidimensional Gas Chromatography: An Update of Recent Studies, Technology, and Applications. Anal Chem. 2023; 95: 238-63.

[184]

Ferreira MM, Marins—Gonçalves L, Souza DD. An integrative review of analytical techniques used in food authentication: A detailed description for milk and dairy products. Food Chem. 2024; 457: 140206.

[185]

Haider A, Iqbal SZ, Bhatti IA, Alim MB, Waseem M, Iqbal M, et al. Food authentication, current issues, analytical techniques, and future challenges: A comprehensive review. Compr Rev Food Sci Food Saf. 2024; 23: e13360.

[186]

Sobolev AP, Thomas F, Donarski J, Ingallina C, Circi S, Cesare Marincola F, et al. Use of NMR applications to tackle future food fraud issues. Trends Food Sci Tech. 2019; 91: 347-53.

[187]

Zhong P, Wei X, Li X, Wei X, Wu S, Huang W, et al. Untargeted metabolomics by liquid chromatography—mass spectrometry for food authentication: A review. Compr Rev Food Sci Food Saf. 2022; 21: 2455—88.

[188]

Mahrous E, Chen R, Zhao C, Farag MA. Lipidomics in food quality and authentication: A comprehensive review of novel trends and applications using chromatographic and spectroscopic techniques. Crit Rev Food Sci Nutr. 2024; 64: 9058—81.

[189]

Cagliani LR, Pellegrino G, Giugno G, Consonni R. Quantification of Coffea arabica and Coffea canephora var. robusta in roasted and ground coffee blends. Talanta. 2013; 106: 169-73.

[190]

Schievano E, Finotello C, Angelis ED, Mammi S, Navarini L. Rapid authentication of coffee blends and quantification of 16—O—methylcafestol in roasted coffee beans by nuclear magnetic resonance. J Agric Food Chem. 2014; 62: 12309—14.

[191]

Schievano E, Peggion E, Mammi S. 1H nuclear magnetic resonance spectra of chloroform extracts of honey for chemometric determination of its botanical origin. J Agric Food Chem. 2010; 58: 57-65.

[192]

Yilmaz A, Nyberg NT, Mølgaard P, Asili J, Jaroszewski JW. 1H NMR metabolic fingerprinting of saffron extracts. Metabolomics. 2010; 6: 511-7.

[193]

Mannina L, D’Imperio M, Capitani D, Rezzi S, Guillou C, Mavromoustakos T, et al. 1H NMR—based protocol for the detection of adulterations of refined olive oil with refined hazelnut oil. J Agric Food Chem. 2009; 57: 11550-6.

[194]

Mannina L, Marini F, Antiochia R, Cesa S, Magrì A, Capitani D, et al. Tracing the origin of beer samples by NMR and chemometrics: Trappist beers as a case study. Electrophoresis. 2016; 37: 2710—9.

[195]

Dou X, Zhang L, Yang R, Wang X, Yu L, Yue X, et al. Mass spectrometry in food authentication and origin traceability. Mass Spectrom Rev. 2023; 42: 1772-807.

[196]

Frigerio J, Campone L, Giustra MD, Buzzelli M, Piccoli F, Galimberti A, et al. Convergent technologies to tackle challenges of modern food authentication. Heliyon. 2024; 10: e32297.

[197]

Barrias S, Fernandes JR, Eiras—Dias JE, Brazão J, Martins—Lopes P. Label free DNA—based optical biosensor as a potential system for wine authenticity. Food Chem. 2019; 270: 299-304.

[198]

Barrias S, Ibañéz J, Fernandes R, Martins—Lopes P. The role of DNA—based biosensors in species identification for food authenticity assessment. Trends Food Sci Tech. 2024; 145: 104350.

[199]

Labuda J, Brett AMO, Evtugyn G, Fojta M, Mascini M, Ozsoz M, et al. Electrochemical nucleic acid—based biosensors: Concepts, terms, and methodology (IUPAC Technical Report). Pure Appl Chem. 2010; 82: 1161—87.

[200]

Pereira L, Gomes S, Barrias S, Gomes EP, Baleiras—Couto M, Fernandes JR, et al. From the Field to the Bottle—An Integrated Strategy for Wine Authenticity. Beverages. 2018; 4: 71.

[201]

Zhou R, Zhao L, Wang Y, Hameed S, Ping J, Xie L, et al. Recent advances in food—derived nanomaterials applied to biosensing. Trends Analytical Chem. 2020; 127: 115884.

[202]

Bai S, Li S, Yao T, Hu Y, Bao F, Zhang J, et al. Rapid detection of eight vegetable oils on optical thin—film biosensor chips. Food Control. 2011; 22: 1624-8.

[203]

Bai S, Xu L, Wang Y, Yang X, Zhu F, Chen Y, et al. A simple and reliable qualitative detection of six foodstuff powders using optical thin—film biosensor chips. Eur Food Res Technol. 2013; 236: 899-904.

[204]

Valdés A, Álvarez—Rivera G, Socas—Rodríguez B, Herrero M, Ibáñez E, Cifuentes A. Foodomics: Analytical Opportunities and Challenges. Anal Chem. 2022; 94: 366-81.

[205]

Cifuentes A. Foodomics, foodome and modern food analysis. Trends Anal Chem. 2017; 96: 1.

[206]

Valdés A, Cifuentes A, León C. Foodomics evaluation of bioactive compounds in foods. Trends Anal Chem. 2017; 96: 2-13.

[207]

Cifuentes A. Food analysis and foodomics. J Chromatogr A. 2009; 1216: 7109.

[208]

Ibáñez C, Valdés A, García—Cañas V, Simó C, Celebier M, Rocamora—Reverte L, et al. Global Foodomics strategy to investigate the health benefits of dietary constituents. J Chromatogr A. 2012; 1248: 139-53.

[209]

Fiehn O. Metabolomics——the link between genotypes and phenotypes. Plant Mol Biol. 2002; 48: 155-71.

[210]

García—Cañas V, Simó C, León C, Cifuentes A. Advances in Nutrigenomics research: novel and future analytical approaches to investigate the biological activity of natural compounds and food functions. J Pharm Biomed Anal. 2010; 51: 290-304.

[211]

Villas—Bôas SG, Mas S, Akesson M, Smedsgaard J, Nielsen J. Mass spectrometry in metabolome analysis. Mass Spectrom Rev. 2005; 24: 613—46.

[212]

Shulaev V. Metabolomics technology and bioinformatics. Brief Bioinform. 2006; 7: 128-39.

[213]

Ortea O. Foodomics in health: Advanced techniques for studying the bioactive role of foods. Trends Anal Chem. 2022; 150: 116589.

[214]

Tanaka K, Waki H, Ido Y, Akita S, Yoshida Y, Yoshida T, et al. Protein and polymer analyses up to m/z 100 000 by laser ionization time—of—flight mass spectrometry. Rapid Commun Mass Spectrom. 1988; 2: 151—3.

[215]

Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM. Electrospray ionization for mass spectrometry of large biomolecules. Science. 1989; 246: 64-71.

[216]

McLafferty FW, Fridriksson EK, Horn DM, Lewis MA, Zubarev RA. Techview: biochemistry. Biomolecule mass spectrometry. Science. 1999; 284: 1289—90.

[217]

Zhang X, Clausen MR, Zhao X, Zheng H, Bertram HC. Enhancing the power of liquid chromatography—mass spectrometry—based urine metabolomics in negative ion mode by optimization of the additive. Anal Chem. 2012; 84: 7785-92.

[218]

Yu Q, Paulo JA, Naverrete—Perea J, McAlister GC, Canterbury JD, Bailey DJ, et al. Benchmarking the Orbitrap Tribrid Eclipse for Next Generation Multiplexed Proteomics. Anal Chem. 2020; 92: 6478—85.

[219]

Yan S, Bhawal R, Yin Z, Thannhauser TW, Zhang S. Recent advances in proteomics and metabolomics in plants. Mol Hortic. 2022; 2: 17.

[220]

Hernández—Mesa M, D’Atri V, Barknowitz G, Fanuel M, Pezzatti J, Dreolin N, et al. Interlaboratory and Interplatform Study of Steroids Collision Cross Section by Traveling Wave Ion Mobility Spectrometry. Anal Chem. 2020; 92: 5013—22.

[221]

Meier F, Park MA, Mann M. Trapped Ion Mobility Spectrometry and Parallel Accumulation—Serial Fragmentation in Proteomics. Mol Cell Proteomics. 2021; 20: 100138.

[222]

Hebert AS, Prasad S, Belford MW, Bailey DJ, McAlister GC, Abbatiello SE, et al. Comprehensive Single—Shot Proteomics with FAIMS on a Hybrid Orbitrap Mass Spectrometer. Anal Chem. 2018; 90: 9529—37.

[223]

Velculescu VE, Zhang L, Vogelstein B, Kinzler KW. Serial analysis of gene expression. Science. 1995; 270: 484—7.

[224]

Brenner S, Johnson M, Bridgham J, Golda G, Lloyd DH, Johnson D, et al. Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol. 2000; 18: 630—4.

[225]

Morozova O, Marra MA. Applications of next—generation sequencing technologies in functional genomics. Genomics. 2008; 92: 255-64.

[226]

Kharbach M, Mansouri MA, Taabouz M, Yu H. Current Application of Advancing Spectroscopy Techniques in Food Analysis: Data Handling with Chemometric Approaches. Foods. 2023; 12: 2753.

[227]

González—Domínguez R, Sayago A, Fernández—Recamales Á. An Overview on the Application of Chemometrics Tools in Food Authenticity and Traceability. Foods. 2022; 11: 3940.

[228]

Gavahian M. Valorized pineapple waste by conventional and energy—saving ohmic extraction: potentially toxic elements and mycotoxin contamination. Qual Assur Saf Crops Foods. 2023; 15: 11-20.

[229]

Alsaedi AWM, Al—Hilphy AR, Al—Mousawi AJ, Gavahian M. Non—thermal pasteurization of milk by elongated electrode moderate electrical field: Chemical and sensory analysis during cold storage and shelf—life determination. Innovative Food Sci Emerging Technol. 2024; 94: 103647.

[230]

Gavahian M, Yang Y, Tsai P. Power ultrasound for valorization of Citrus limon (cv. Eureka) waste: Effects of maturity stage and drying method on bioactive compounds, antioxidant, and anti—diabetic activity. Innovative Food Sci Emerging Technol. 2022; 79: 103052.

[231]

Gavahian M, Manyatsi TS, Morata A, Tiwari BK. Ultrasound—assisted production of alcoholic beverages: From fermentation and sterilization to extraction and aging. Compr Rev Food Sci Food Saf. 2022; 21: 5243-71.

[232]

Abderrezag N, Montenegro ZJS, Louaer O, Meniai A, Cifuentes A, Ibáñez E, et al. One—step sustainable extraction of Silymarin compounds of wild Algerian milk thistle (Silybum marianum) seeds using Gas Expanded Liquids. J Chromatogr A. 2022; 1675: 463147.

[233]

Morel J, Catchpole O, Moreno T, Lagutin K, MacKenzie A, Fenton T, et al. Extraction of neutral lipids and phospholipids from marine biomasses using subcritical and supercritical fluids. J Supercrit Fluids. 2024; 206: 106160.

[234]

Benvenutti L, Zielinski AAF, Ferreira SRS. Which is the best food emerging solvent: IL, DES or NADES? Trends Food Sci Tech. 2019; 90: 133—46.

[235]

Bragagnolo FS, Socas—Rodríguez B, Mendiola JA, Cifuentes A, Funari CS, Ibáñez E. Pressurized natural deep eutectic solvents: An alternative approach to agro—soy by—products. Front Nutr. 2022; 9: 953169.

[236]

Benvenutti L, Zielinski AAF, Ferreira SRS. Pressurized aqueous solutions of deep eutectic solvent (DES): A green emergent extraction of anthocyanins from a Brazilian berry processing by—product. Food Chem X. 2022; 13: 100236.

[237]

Andrade KS, Aguiar GPS, Rebelatto EA, Lanza M, Oliveira JV, Ferreira SRS. Encapsulation of pink pepper extract by SEDS technique: Phase behavior data and process parameters. J Supercrit Fluids. 2020; 161: 104822.

[238]

Reis PMCL, Mezzomo N, Aguiar GPS, Senna EMTL, Hense H, Ferreira SRS. Ultrasound—assisted emulsion of laurel leaves essential oil (Laurus nobilis L.) encapsulated by SFEE. J Supercrit Fluids. 2019; 147: 284-92.

[239]

Mezzomo N, de Paz E, Maraschin M, Martín Á, Cocero MJ, Ferreira SRS. Supercritical anti—solvent precipitation of carotenoid fraction from pink shrimp residue: Effect of operational conditions on encapsulation efficiency. J Supercrit Fluids. 2012; 66: 342-9.

[240]

dos Santos AE, Dal Magro C, de Britto LS, Aguiar GPS, de Oliveira JV, Lanza M. Micronization of luteolin using supercritical carbon dioxide: Characterization of particles and biological activity in vitro. J Supercrit Fluids. 2022; 181: 105471.

[241]

Arango—Ruiz Á, Martin Á, Cocero MJ, Jiménez C, Londoño J. Encapsulation of curcumin using supercritical antisolvent (SAS) technology to improve its stability and solubility in water. Food Chem. 2018; 258: 156-63.

[242]

van Boekel M, Fogliano V, Pellegrini N, Stanton C, Scholz G, Lalljie S, et al. A review on the beneficial aspects of food processing. Mol Nutr Food Res. 2010; 54: 1215—47.

[243]

Pérez—Burillo S, Pastoriza S, Jiménez—Hernández N, D’Auria G, Francino MP, Rufián—Henares JA. Effect of Food Thermal Processing on the Composition of the Gut Microbiota. J Agric Food Chem. 2018; 66: 11500—9.

[244]

Tomás—Barberán FA, Espín JC. Effect of Food Structure and Processing on (Poly)phenol—Gut Microbiota Interactions and the Effects on Human Health. Annu Rev Food Sci Technol. 2019; 10: 221-38.

[245]

Wicaksono WA, Buko A, Kusstatscher P, Sinkkonen A, Laitinen OH, Virtanen SM, et al. Modulation of the food microbiome by apple fruit processing. Food Microbiol. 2022; 108: 104103.

[246]

Sun H, Duan Y, Li H, Hu X, Li B, Zhuang J, et al. Microbiota characterization of atmospheric cold plasma treated blueberries. LWT. 2023; 180: 114720.

[247]

Luo S, Hou Y, Xie L, Zhang H, Liu C, Chen T. Effects of microwave on the potential microbiota modulating effects of agro—industrial by—product fibers among different individuals. LWT. 2023; 178: 114621.

[248]

Zagdoun M, Coeuret G, N’Dione M, Champomier—Vergès M, Chaillou S. Large microbiota survey reveals how the microbial ecology of cooked ham is shaped by different processing steps. Food Microbiol. 2020; 91: 103547.

[249]

Borges F, Briandet R, Callon C, Champomier—Vergès M, Christieans S, Chuzeville S, et al. Contribution of omics to biopreservation: Toward food microbiome engineering. Front Microbiol. 2022; 13: 951182.

[250]

Oniciuc EA, Likotrafiti E, Alvarez—Molina A, Prieto M, López M, Alvarez—Ordóñez A. Food processing as a risk factor for antimicrobial resistance spread along the food chain. Curr Opin Food Sci. 2019; 30: 21-6.

[251]

Capita R, Alonso—Calleja C. Antibiotic—resistant bacteria: a challenge for the food industry. Crit Rev Food Sci Nutr. 2013; 53: 11-48.

[252]

Scaccia N, Vaz—Moreira I, Manaia CM. The risk of transmitting antibiotic resistance through endophytic bacteria. Trends Plant Sci. 2021; 26: 1213-26.

[253]

Tadapaneni RK, Daryaei H, Krishnamurthy K, Edirisinghe I, Burton—Freeman BM. High—pressure processing of berry and other fruit products: implications for bioactive compounds and food safety. J Agric Food Chem. 2014; 62: 3877—85.

[254]

Weber F. Noncovalent Polyphenol—Macromolecule Interactions and Their Effects on the Sensory Properties of Foods. J Agric Food Chem. 2022; 70: 72-8.

[255]

Saini RK, Shetty NP, Prakash M, Giridhar P. Effect of dehydration methods on retention of carotenoids, tocopherols, ascorbic acid and antioxidant activity in Moringa oleifera leaves and preparation of a RTE product. J Food Sci Technol. 2014; 51: 2176—82.

[256]

Saini RK, Nile SH, Park SW. Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. Food Res Int. 2015; 76: 735—50.

[257]

Pan Y, Cheng J, Sun D. Inhibition of fruit softening by cold plasma treatments: affecting factors and applications. Crit Rev Food Sci Nutr. 2021; 61: 1935—46.

[258]

Bayati M, Manzari Tavakoli M, Nejad Ebrahimi S, Aliahmadi A, Rezadoost H. Optimization of effective parameters in cold pasteurization of pomegranate juice by response surface methodology and evaluation of physicochemical characteristics. LWT. 2021; 147: 11167.

[259]

Bayati M, Lund MN, Tiwari BK, Poojary MM. Chemical and physical changes induced by cold plasma treatment of foods: A critical review. Compr Rev Food Sci Food Saf. 2024; 23: e13376.

[260]

Schieber A. Reactions of Quinones—Mechanisms, Structures, and Prospects for Food Research. J Agric Food Chem. 2018; 66: 13051—5.

[261]

Hu J, Li X, Yu Q, Wang W, Bi J. Understanding the impact of pectin physicochemical variation on browning of simulated Maillard reaction system in thermal and storage processing. Int J Biol Macromol. 2023; 240: 124347.

[262]

Somjai C, Siriwoharn T, Kulprachakarn K, Chaipoot S, Phongphisutthinant R, Wiriyacharee P. Utilization of Maillard reaction in moist—dry—heating system to enhance physicochemical and antioxidative properties of dried whole longan fruit. Heliyon. 2021; 7: e07094.

[263]

Kuzan A. Toxicity of advanced glycation end products (Review). Biomed Rep. 2021; 14: 46.

[264]

Millet M, Poupard P, Guilois—Dubois S, Poiraud A, Fanuel M, Rogniaux H, et al. Heat—unstable apple pathogenesis—related proteins alone or interacting with polyphenols contribute to haze formation in clear apple juice. Food Chem. 2020; 309: 125636.

[265]

Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 2012; 3: 200-1.

[266]

Beltrán—Martínez ME, Tapia—Rodríguez MR, Ayala—Zavala JF, Gómez—Álvarez A, Robles—Zepeda RE, Torres—Moreno H, et al. Antimicrobial and Antibiofilm Potential of Flourensia retinophylla against Staphylococcus aureus . Plants (Basel). 2024; 13: 1671.

[267]

An AY, Choi KG, Baghela AS, Hancock REW. An Overview of Biological and Computational Methods for Designing Mechanism—Informed Anti—biofilm Agents. Front Microbiol. 2021; 12: 640787.

[268]

Gennari O, Marchesano V, Rega R, Mecozzi L, Nazzaro F, Fratianni F, et al. Pyroelectric Effect Enables Simple and Rapid Evaluation of Biofilm Formation. ACS Appl Mater Interfaces. 2018; 10: 15467—76.

[269]

Ali NB, El—Shiekh RA, Ashour RM, El—Gayed SH, Abdel—Sattar E. Agro—Food Waste: Harnessing the Potential Significance of Natural Biofilm Inhibitors. Trop J Nat Prod Res. 2023; 7: 5366-76.

[270]

Fratianni F, Cozzolino A, De Feo V, Coppola R, Ombra MN, Nazzaro F. Polyphenols, Antioxidant, Antibacterial, and Biofilm Inhibitory Activities of Peel and Pulp of Citrus medica L., Citrus bergamia, and Citrus medica cv. Salò Cultivated in Southern Italy. Molecules. 2019; 24: 4577.

[271]

Choi KG, Wu BC, Lee AH, Baquir B, Hancock REW. Utilizing Organoid and Air—Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides. Front Cell Infect Microbiol. 2020; 10: 228.

[272]

Tang M, Liao S, Qu J, Liu Y, Han S, Cai Z, et al. Evaluating Bacterial Pathogenesis Using a Model of Human Airway Organoids Infected with Pseudomonas aeruginosa Biofilms. Microbiol Spectr. 2022; 10: e0240822.

[273]

Wu BC, Haney EF, Akhoundsadegh N, Pletzer D, Trimble MJ, Adriaans AE, et al. Human organoid biofilm model for assessing antibiofilm activity of novel agents. NPJ Biofilms Microbiomes. 2021; 7: 8.

[274]

Dinteren SV, Araya—Cloutier C, Robaczewska E, den Otter M, Witkamp R, Vincken JP, et al. Switching the polarity of mouse enteroids affects the epithelial interplay with prenylated phenolics from licorice (Glycyrrhiza) roots. Food Funct. 2024; 15: 1852-66.

[275]

Gómez—Estaca J, López—de—Dicastillo C, Hernández—Muñoz P, Catalá R, Gavara R. Advances in antioxidant active food packaging. Trends Food Sci Tech. 2014; 35: 42-51.

[276]

Öztürk M, Ayhan Z. Combined effects of ethylene scavenging—active packaging system and modified atmosphere to reduce postharvest losses of ethylene sensitive produce: Banana and kiwifruit. Packag Technol Sci. 2023; 36: 95167.

[277]

Barros—Velazquez J, editor. Antimicrobial Food Packaging. Academic Press; 2025.

[278]

Esteve—Redondo P, Heras—Mozos R, Simó—Ramírez E, López—Carballo G, López—de—Dicastillo C, Gavara R, et al. Innovative Systems for the Delivery of Naturally Occurring Antimicrobial Volatiles in Active Food—Packaging Technologies for Fresh and Minimally Processed Produce: Stimuli—Responsive Materials. Foods. 2024; 13: 856.

[279]

Settier—Ramirez L, López—Carballo G, Hernandez—Muñoz P, Tinitana—Bayas R, Gavara R, Sanjuán N. Assessing the environmental consequences of shelf life extension: Conventional versus active packaging for pastry cream. J Clean Prod. 2022; 333: 130159.

[280]

Ghaani M, Cozzolino CA, Castelli G, Farris S. An overview of the intelligent packaging technologies in the food sector. Trends Food Sci Tech. 2016; 51: 1-11.

[281]

Zeng T, Deschênes J, Durif F. Eco—design packaging: An epistemological analysis and transformative research agenda. J Clean Prod. 2020; 276: 123361.

[282]

Vignali G. Life—Cycle Assessment of Food—Packaging Systems. In: Muthu S, editor. Environmental Footprints of Packaging. Environmental Footprints and Eco—design of Products and Processes. Singapore: Springer; 2015. pp. 1-22.

[283]

Valero A, Valero A. Thermodynamic Rarity and Recyclability of Raw Materials in the Energy Transition: The Need for an In—Spiral Economy. Entropy. 2019; 21: 873.

[284]

Cheng J, Gao R, Zhu Y, Lin Q. Applications of biodegradable materials in food packaging: A review. Alexandria Eng J. 2024; 91: 70-83.

[285]

Deeney M, Green R, Yan X, Dooley C, Yates J, Rolker HB, et al. Human health effects of recycling and reusing food sector consumer plastics: A systematic review and meta—analysis of life cycle assessments. J Clean Prod. 2023; 397: 136567.

[286]

Ügdüler S, Van Laere T, De Somer T, Gusev S, Van Geem KM, Kulawig A, et al. Understanding the complexity of deinking plastic waste: An assessment of the efficiency of different treatments to remove ink resins from printed plastic film. J Hazard Mater. 2023; 452: 131239.

[287]

Rein MJ, Renouf M, Cruz—Hernandez C, Actis—Goretta L, Thakkar SK, da Silva Pinto M. Bioavailability of bioactive food compounds: a challenging journey to bioefficacy. Br J Clin Pharmacol. 2013; 75: 588-602.

[288]

Oracz J, Nebesny E, Zyzelewicz D, Budryn G, Luzak B. Bioavailability and metabolism of selected cocoa bioactive compounds: A comprehensive review. Crit Rev Food Sci Nutr. 2020; 60: 1947—85.

[289]

Dima C, Assadpour E, Dima S, Jafari SM. Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by in vitro methods. Compr Rev Food Sci Food Saf. 2020; 19: 2862—84.

[290]

Zhao W, Subbiah V, Xie C, Yang Z, Shi L, Barrow C, et al. Bioaccessibility and Bioavailability of Phenolic Compounds in Seaweed. Food Rev Int. 2023; 39: 5729-60.

[291]

Minekus M, Alminger M, Alvito P, Ballance S, Bohn T, Bourlieu C, et al. A standardised static in vitro digestion method suitable for food—an international consensus. Food Funct. 2014; 5: 1113-24.

[292]

Lafond M, Bouza B, Eyrichine S, Rouffineau F, Saulnier L, Giardina T, et al. In vitro gastrointestinal digestion study of two wheat cultivars and evaluation of xylanase supplementation. J Anim Sci Biotechnol. 2015; 6: 5.

[293]

Sensoy I. A review on the food digestion in the digestive tract and the used in vitro models. Curr Res Food Sci. 2021; 4: 308—19.

[294]

Rodriquez—Saavedra M, Tamargo A, Molinero N, Relaño de la Guía E, Jiménez—Arroyo C, Bartolomé B, et al. Simulated gastrointestinal digestion of beer using the simgi® model. Investigation of colonic phenolic metabolism and impact on human gut microbiota. Food Res Int. 2023; 173: 113228.

[295]

Carbonell—Capella JM, Buniowska M, Barba FJ, Esteve MJ, Frígola A. Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review. Compr Rev Food Sci Food Saf. 2014; 13: 155-71.

[296]

Rodrigues DB, Marques MC, Hacke A, Filho PSL, Cazarin CBB, Mariutti LRB. Trust your gut: Bioavailability and bioaccessibility of dietary compounds. Curr Res Food Sci. 2022; 5: 228-33.

[297]

Cardoso C, Alfonso C, Lourenço H, Costa S, Nunes ML. Bioaccessibility assessment methodologies and their consequences for the risk—benefit evaluation of food. Trends Food Sci Tech. 2015; 41: 5-23.

[298]

Borges G, Ottaviani JI, van der Hooft JJJ, Schroeter H, Crozier A. Absorption, metabolism, distribution and excretion of (—)—epicatechin: A review of recent findings. Mol Aspects Med. 2018; 61: 18-30.

[299]

Kerns EH, Di L. Transporters. In: Drug—like Properties: Concepts, Structure Design and Methods, from ADME to Toxicity Optimization. 1st ed. London: Elsevier; 2008. pp. 103-21.

[300]

Brand W, Schutte ME, Williamson G, van Zanden JJ, Cnubben NH, Groten JP, et al. Flavonoid—mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food—borne toxic compounds and bioactive ingredients. Biomed Pharmacother. 2006; 60: 508-19.

[301]

Sobel R, Versic R, Gaonkar AG. Chapter 1—Introduction to microencpsulation and controlled delivery in foods. In: Sobel R, editor. Microencapsulation in the Food Industry (Second Edition). A Practical Implementation Guide. Academic Press; 2023. pp. 1-9.

[302]

Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res. 1996; 13: 1838-45.

[303]

Fei T, Gwinn K, Leyva—Gutierrez FMA, Wang T. Nanoemulsions of terpene by—products from cannabidiol production have promising insecticidal effect on Callosobruchus maculatus . Heliyon. 2023; 9: e15101.

[304]

Cheng X, Yan H, Pang S, Ya M, Qiu F, Qin P, et al. Liposomes as Multifunctional Nano—Carriers for Medicinal Natural Products. Front Chem. 2022; 10: 963004.

[305]

Akanda M, Sadeque Hossain Mithu MD, Douroumis D. Solid Lipid nanoparticels: An effective lipid—based technology for cancer treatment. J Drug Delivery Sci Technol. 2023; 86: 104709.

[306]

Lasoń E. Topical Administration of Terpenes Encapsulated in Nanostructured Lipid—Based Systems. Molecules. 2020; 25: 5758.

[307]

Andleeb M, Khan HMS, Daniyal M. Development, Characterization and Stability Evaluation of Topical Gel Loaded With Ethosomes Containing Achillea millefolium L. Extract. Front Pharmacol. 2021; 12: 603227.

[308]

Alharbi WS, Almughem FA, Almehmady AM, Jarallah SJ, Alsharif WK, Alzahrani NM, et al. Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals. Pharmaceutics. 2021; 13: 1475.

[309]

Ge X, Wei M, He S, Yuan W. Advances of Non—Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery. Pharmaceutics. 2019; 11: 55.

[310]

Zhang K, Zhang Y, Li Z, Li N, Feng N. Essential oil—mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo. Int J Nanomedicine. 2017; 12: 3521—32.

[311]

Kaltschmidt BP, Ennen I, Greiner JFW, Dietsch R, Patel A, Kaltschmidt B, et al. Preparation of Terpenoid—Invasomes with Selective Activity against S. aureus and Characterization by Cryo Transmission Electron Microscopy. Biomedicines. 2020; 8: 105.

[312]

Rodrigues FJ, Cedran MF, Bicas JL, Sato HH. Encapsulated probiotic cells: Relevant techniques, natural sources as encapsulating materials and food applications—A narrative review. Food Res Int. 2020; 137: 109682.

[313]

Subramani T, Ganapathyswamy H. An overview of liposomal nano—encapsulation techniques and its applications in food and nutraceutical. J Food Sci Technol. 2020; 57: 3545—55.

[314]

Akram N, Afzaal M, Saeed F, Shah YA, Faisal Z, Asghar A, et al. Liposomes: a promising delivery systema for active ingredients in food and nutrition. Int J Food Prop. 2023; 26: 2476-92.

[315]

Rubert J, Schweiger PJ, Mattivi F, Tuohy K, Jensen KB, Lunardi A. Intestinal Organoids: A Tool for Modelling Diet—Microbiome—Host Interactions. Trends Endocrinol Metab. 2020; 31: 848-58.

[316]

Liu J, Tan Y, Cheng H, Zhang D, Feng W, Peng C. Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives. Aging Dis. 2022; 13: 1106-26.

[317]

Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The Microbiota—Gut—Brain Axis. Physiol Rev. 2019; 99: 1877-2013.

[318]

Capuano E, Oliviero T, Fogliano V, Pellegrini N. Role of the food matrix and digestion on calculation of the actual energy content of food. Nutr Rev. 2018; 76: 274-89.

[319]

McDonald JAK. In vitro models of the human microbiota and microbiome. Emerg Top Life Sci. 2017; 1: 373-84.

[320]

Brodkorb A, Egger L, Alminger M, Alvito P, Assunção R, Ballance S, et al. INFOGEST static in vitro simulation of gastrointestinal food digestion. Nat Protoc. 2019; 14: 991-1014.

[321]

Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, et al. Long—term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 2011; 141: 1762—72.

[322]

Sato T, Clevers H. SnapShot: Growing Organoids from Stem Cells. Cell. 2015; 161: 1700, e1.

[323]

Co JY, Margalef—Català M, Monack DM, Amieva MR. Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases. Nat Protoc. 2021; 16: 5171-92.

[324]

Zietek T, Rath E, Haller D, Daniel H. Intestinal organoids for assessing nutrient transport, sensing and incretin secretion. Sci Rep. 2015; 5: 16831.

[325]

Li Y, Zhang T, Guo C, Geng M, Gai S, Qi W, et al. Bacillus subtilis RZ001 improves intestinal integrity and alleviates colitis by inhibiting the Notch signalling pathway and activating ATOH—1. Pathog Dis. 2020; 78: ftaa016.

[326]

Toden S, Ravindranathan P, Gu J, Cardenas J, Yuchang M, Goel A. Oligomeric proanthocyanidins (OPCs) target cancer stem—like cells and suppress tumor organoid formation in colorectal cancer. Sci Rep. 2018; 8: 3335.

[327]

Hou Z, Meng R, Chen G, Lai T, Qing R, Hao S, et al. Distinct accumulation of nanoplastics in human intestinal organoids. Sci Total Environ. 2022; 838: 155811.

[328]

van der Hee B, Loonen LMP, Taverne N, Taverne—Thiele JJ, Smidt H, Wells JM. Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids. Stem Cell Res. 2018; 28: 165-71.

[329]

Santini A, Cammarata SM, Capone G, Ianaro A, Tenore GC, Pani L, et al. Nutraceuticals: opening the debate for a regulatory framework. Br J Clin Pharmacol. 2018; 84: 659-72.

[330]

Tsiaka T, Kritsi E, Tsiantas K, Christodoulou P, Sinanoglou VJ, Zoumpoulakis P. Design and Development of Novel Nutraceuticals: Current Trends and Methodologies. Nutraceuticals. 2022; 2: 71-90.

[331]

Puttasiddaiah R, Lakshminarayana R, Somashekar NL, Gupta VK, Inbaraj BS, Usmani Z, et al. Advances in Nanofabrication Technology for Nutraceuticals: New Insights and Future Trends. Bioengineering (Basel). 2022; 9: 478.

[332]

Ayuda—Durán B, González—Manzano S, González—Paramás AM, Santos—Buelga C. Caernohabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals. Molecules. 2020; 25: 3194.

[333]

Okoro NO, Odiba AS, Osadebe PO, Omeje EO, Liao G, Fang W, et al. Bioactive Phytochemicals with Anti—Aging and Lifespan Extending Potentials in Caenorhabditis elegans . Molecules. 2021; 26: 7323.

[334]

Hu J, Mesnage R, Tuohy K, Heiss C, Rodriguez—Mateos A. (Poly)phenol—related gut metabotypes and human health: an update. Food Funct. 2024; 15: 2814-35.

[335]

Zorraquín I, Sánchez—Hernández E, Ayuda—Durán B, Silva M, González—Paramás AM, Santos—Buelga C, et al. Current and future experimental approaches in the study of grape and wine polyphenols interacting gut microbiota. J Sci Food Agric. 2020; 100: 3789-802.

[336]

Bordoni A, Capozzi F. Foodomics for healthy nutrition. Curr Opin Clin Nutr Metab Care. 2014; 17: 418—24.

[337]

Capozzi F. Food Innovation in the Frame of Circular Economy by Designing Ultra—Processed Foods Optimized for Sustainable Nutrition. Front Nutr. 2022; 9: 886220.

[338]

Capozzi F, Magkos F, Fava F, Milani GP, Agostoni C, Astrup A, et al. A Multidisciplinary Perspective of Ultra—Processed Foods and Associated Food Processing Technologies: A View of the Sustainable Road Ahead. Nutrients. 2021; 13: 3948.

[339]

Mengucci C, Ferranti P, Romano A, Masi P, Picone G, Capozzi F. Food structure, function and artificial intelligence. Trends Food Sci Technol. 2022; 123: 251-63.

[340]

Kokesch—Himmelreich J, Wittek O, Race AM, Rakete S, Schlicht C, Busch U, et al. MALDI mass spectrometry imaging: From constituents in fresh food to ingredients, contaminants and additives in processed food. Food Chem. 2022; 385: 132529.

[341]

Heertje I. Structure and function of food products: A review. Food Struct. 2014; 1: 3-23.

[342]

Langton M, Åström A, Hermansson AM. Influence of the microstructure on the sensory quality of whey protein gels. Food Hydrocoll. 1997; 11: 217—30.

[343]

Wu Y, Okesola BO, Xu J, Korotkin I, Berardo A, Corridori I, et al. Disordered protein—graphene oxide co—assembly and supramolecular biofabrication of functional fluidic devices. Nat Commun. 2020; 11: 1182.

[344]

Zinöcker MK, Lindseth IA. The Western Diet—Microbiome—Host Interaction and Its Role in Metabolic Disease. Nutrients. 2018; 10: 365.

[345]

Mariath AB, Machado AD, Ferreira LDNM, Ribeiro SML. The possible role of increased consumption of ultra—processed food products in the development of frailty: a threat for healthy ageing? Br J Nutr. 2022; 128: 461—6.

[346]

McClements DJ. Food hydrocolloids: Application as functional ingredients to control lipid digestion and bioavailability. Food Hydrocoll. 2021; 111: 106404.

[347]

Žolnere K, Arnold M, Hull B, Everett DW. Cheese proteolysis and matrix disintegration during in vitro digestion. Food Struct. 2019; 21: 100114.

[348]

Fundo JF, Quintas MAC, Silva CLM. Molecular Dynamics and Structure in Physical Properties and Stability of Food Systems. Food Eng Rev. 2015; 7: 384-92.

[349]

Lysak DH, Bermel W, Moxley—Paquette V, Michal C, Ghosh—Biswas R, Soong R, et al. Cutting without a Knife: A Slice—Selective 2D1H—13C HSQC NMR Sequence for the Analysis of Inhomogeneous Samples. Anal Chem. 2023; 95: 14392—401.

[350]

Medcalf A, Atkin K. Chronic challenges: picturing chronic disease by the World Health Organization. Med Humanit. 2024;medhum—2023—012737.

[351]

Ijeh S, Okolo CA, Arowoogun JO, Adeniyi AO, Omotayo O. Predictive modeling for disease outbreaks: a review of data sources and accuracy. Int Med Sci Res J. 2024; 4: 406—19.

[352]

Sharma M, Vidhya CS, Ojha K, Yashwanth BS, Singh B, Gupta S, et al. The Role of Functional Foods and Nutraceuticals in Disease Prevention and Health Promotion. Eur J Nutr Food Saf. 2024; 16: 61-83.

[353]

Theodoridis S, Drakou EG, Hickler T, Thines M, Nogues—Bravo D. Evaluating natural medicinal resources and their exposure to global change. Lancet Planet Health. 2023; 7: e155-63.

[354]

Dhyani P, Quispe C, Sharma E, Bahukhandi A, Sati P, Attri DC, et al. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022; 22: 206.

[355]

Linhares Y, Kaganski A, Agyare C, Kurnaz IA, Neergheen V, Kolodziejczyk B, et al. Biodiversity: the overlooked source of human health. Trends Mol Med. 2023; 29: 173-87.

[356]

Davis CC, Choisy P. Medicinal plants meet modern biodiversity science. Curr Biol. 2024; 34: R158-73.

[357]

Sarkki S, Pihlajamäki M, Rasmus S, Eronen JT. “Rights for Life” scenario to reach biodiversity targets and social equity for indigenous peoples and local communities. Biol Conserv. 2023; 280: 109958.

[358]

Mrabet R. Sustainable agriculture for food and nutritional security. In: Sustainable agriculture and the environment. Academic Press; 2023. pp. 25-90.

[359]

Camina JL, Usseglio V, Marquez V, Merlo C, Dambolena JS, Zygadlo JA, et al. Ecological interactions affect the bioactivity of medicinal plants. Sci Rep. 2023; 13: 12165.

[360]

Cena H, Labra M; Group NC; NBFC Collaborator Group. Biodiversity and planetary health: a call for integrated action. Lancet. 2024; 403: 1985—6.

[361]

Mumford EL, Martinez DJ, Tyance—Hassell K, Cook A, Hansen GR, Labonté R, et al. Evolution and expansion of the One Health approach to promote sustainable and resilient health and well—being: A call to action. Front Public Health. 2023; 10: 1056459.

[362]

Laing G, Duffy E, Anderson N, Antoine—Moussiaux N, Aragrande M, Luiz Beber C, et al. Advancing One Health: updated core competencies. CABI One Health. 2023;ohcs20230002.

[363]

Mubareka S, Amuasi J, Banerjee A, Carabin H, Copper Jack J, Jardine C, et al. Strengthening a One Health approach to emerging zoonoses. FACETS. 2023; 8: 1-64.

[364]

Babu M, Snyder M. Multi—Omics Profiling for Health. Mol Cell Proteomics. 2023; 22: 100561.

[365]

Castaldo G, Pagano I, Grimaldi M, Marino C, Molettieri P, Santoro A, et al. Effect of Very—Low—Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance—Based Metabolomic Study. J Proteome Res. 2021; 20: 1509-21.

[366]

Castaldo G, Marino C, Atteno M, D’Elia M, Pagano I, Grimaldi M, et al. Investigating the Effectiveness of a Carb—Free Oloproteic Diet in Fibromyalgia Treatment. Nutrients. 2024; 16: 1620.

[367]

Herráiz—Gil S, de Arriba MDC, Escámez MJ, León C. Multi—omic data integration in food science and analysis. Curr Opin Food Sci. 2023; 52: 101049.

[368]

Gao P. The Exposome in the Era of One Health. Environ Sci Technol. 2021; 55: 2790—9.

[369]

Cifuentes A, editor. Comprehensive Foodomics. Elsevier; 2021.

[370]

Sadeghi A, Ebrahimi M, Hajinia F, Kharazmi MS, Jafari SM. FoodOmics as a promising strategy to study the effects of sourdough on human health and nutrition, as well as product quality and safety; back to the future. Trends Food Sci Tech. 2023; 136: 24-47.

[371]

Mall S, Srivastava A. Foodomics: Integrated omics for the food and nutrition science. In: Integrative Omics. Academic Press; 2024. pp. 121—32.

[372]

Stentiford GD, Bateman IJ, Hinchliffe SJ, Bass D, Hartnell R, Santos EM, et al. Sustainable aquaculture through the One Health lens. Nat Food. 2020; 1: 468-74.

[373]

Madruga RP. Linking climate and biodiversity. Science. 2021; 374: 511.

[374]

Groh K, Berg CV, Schirmer K, Tlili A. Anthropogenic Chemicals As Underestimated Drivers of Biodiversity Loss: Scientific and Societal Implications. Environ Sci Technol. 2022; 56: 707-10.

[375]

Pörtner H, Scholes RJ, Arneth A, Barnes DKA, Burrows MT, Diamond SE, et al. Overcoming the coupled climate and biodiversity crises and their societal impacts. Science. 2023; 380: eabl4881.

[376]

van der Putten WH, Bardgett RD, Farfan M, Montanarella L, Six J, Wall DH. Soil biodiversity needs policy without borders. Science. 2023; 379: 32-4.

[377]

Cimatti M, Chaplin—Kramer R, Di Marco M. The role of high—biodiversity regions in preserving Nature’s Contributions to People. Nat Sustain. 2023; 6: 1385-93.

[378]

Fernández—García N, Román—García I, Olmos E. The Outlook for Latin—American Crops: Challenges and Opportunities. In: Latin—American Seeds. CRC Press; 2023. pp. 91-118.

[379]

Salvador—Reyes R, Furlan LC, Martínez—Villaluenga C, Dala—Paula BM, Clerici MTPS. From ancient crop to modern superfood: Exploring the history, diversity, characteristics, technological applications, and culinary uses of Peruvian fava beans. Food Res Int. 2023; 173: 113394.

[380]

Pendrill F, Gardner TA, Meyfroidt P, Persson UM, Adams J, Azevedo T, et al. Disentangling the numbers behind agriculture—driven tropical deforestation. Science. 2022; 377: eabm9267.

PDF (6134KB)

15

Accesses

0

Citation

Detail

Sections
Recommended

/