Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies

Juan Manuel Galdopórpora; María Victoria Olivera; Angelina Ibar; Darío Hernán Farriol; Martín Federico Desimone; Cynthia Melisa Melián Queirolo; Helena Pardo; María Victoria Tuttolomondo

doi:10.37349/eds.2025.100895

Exploration of Drug Science ›› 2025, Vol. 3 ›› Issue (1) :100895 DOI: 10.37349/eds.2025.100895

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Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies

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¹ Unidad de Investigación en Bioquímica Traslacional y Metabolismo (UBiTyM), Facultad de Odontología, Universidad de Buenos Aires , CABA 1113, Argentina

² Universidad Nacional de Quilmes , Quilmes 1876, Argentina

³ Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires , CABA 1113, Argentina

⁴ Departamento de Ciencias Químicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires , CABA 1113, Argentina

⁵ Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) , CONICET — Universidad de Buenos Aires, CABA 1113, Argentina

⁶ Departamento de Sanidad, Nutrición, Bromatología y Toxicología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires , CABA 1113, Argentina

⁷ Centro NanoMat, Polo Tecnológico de Pando, Facultad de Química, Universidad de la República , Pando 15600, Uruguay

^*María Victoria Tuttolomondo, Departamento de Ciencias Químicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, CABA 1113, Argentina; Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), CONICET - Universidad de Buenos Aires, CABA 1113, Argentina.mvt@ffyb.uba.ar;mvtuttolomondo@gmail.com

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Abstract

Aim: This study evaluates the efficacy of amino-functionalized mesoporous silica nanoparticles (MSNs) in the controlled release of dexamethasone phosphate (DexaP), aiming to enhance therapeutic outcomes and minimize systemic toxicity.

Methods: In this study, amino-functionalized MSNs were synthesized using a modified Stöber process and characterized their chemical and physical properties through various analytical techniques. The study focused on the adsorption and release kinetics of DexaP, employing multiple kinetic models to explore the interaction dynamics.

Results: The amino-functionalized MSNs demonstrated effective DexaP loading and controlled release profiles. The kinetic analysis revealed a predominance of chemisorptive interactions, supporting sustained drug release. Enhanced biocompatibility was confirmed through cytotoxicity assays.

Conclusions: Amino-functionalized MSNs offer a promising platform for the targeted and controlled delivery of anti-inflammatory drugs, with significant potential to improve patient adherence and reduce adverse effects. The findings advocate for further development of MSNs as a versatile tool in advanced drug delivery systems.

Keywords

Drug delivery / dexamethasone / mesoporous / silica nanoparticles / controlled release / kinetics

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Juan Manuel Galdopórpora, María Victoria Olivera, Angelina Ibar, Darío Hernán Farriol, Martín Federico Desimone, Cynthia Melisa Melián Queirolo, Helena Pardo, María Victoria Tuttolomondo. Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies. Exploration of Drug Science, 2025, 3 (1) : 100895 DOI:10.37349/eds.2025.100895

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