Polymorphism of DNA repair genes (XRCC1, XRCC3, XPD, XPC) and risk of uterine myoma among women working in petrochemical complex

Ol'ga Vadimovna Kochenova; Makhmuza K Gainullina; Tatyana V Victorova

doi:10.17816/ecogen9443-51

Ecological Genetics ›› 2011, Vol. 9 ›› Issue (4) : 43 -51. DOI: 10.17816/ecogen9443-51

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Polymorphism of DNA repair genes (XRCC1, XRCC3, XPD, XPC) and risk of uterine myoma among women working in petrochemical complex

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Abstract

Uterine myoma is a multifactorial disease in which the development involving both genetic and environmental factors. In this study we analyzed polymorphisms of genes excision repair (XRCC1, XPD/ERCC2, XPC) and repair of double-stranded DNA breaks (XRC 3) among women working at a large petrochemical complex of "Salavatnefteorgsintez". It is established that a minor allele homozygous for the minor allele genotype and polymorphism Gln939Lys (rs2228001) XPC gene are associated with the risk of uterine myoma (OR = 3.9 CI 1.001-18.13 for genotype and OR = 2.3 CI 1.36-3.77 for allele).

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Ol'ga Vadimovna Kochenova, Makhmuza K Gainullina, Tatyana V Victorova. Polymorphism of DNA repair genes (XRCC1, XRCC3, XPD, XPC) and risk of uterine myoma among women working in petrochemical complex. Ecological Genetics, 2011, 9(4): 43-51 DOI:10.17816/ecogen9443-51