Analysis of UCPs, PPARs and PGC-1 gene polyorphism in elderly people from North-West region of Russia

Irina V Tarkovskaia; Oleg S Glotov; Tatyana E Ivashchenko; Vladislav S Baranov

doi:10.17816/ecogen9435-42

Ecological Genetics ›› 2011, Vol. 9 ›› Issue (4) : 35 -42. DOI: 10.17816/ecogen9435-42

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Analysis of UCPs, PPARs and PGC-1 gene polyorphism in elderly people from North-West region of Russia

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Abstract

Polymorphism of PPARA G/C, PPARD +294Т/С, PPARG Pro12Ala, PGC-1 Gly482Ser, UCP2 Ala55Val and UCP3 C-55T genes in elderly people (group1) and control group (25-55 aged people) (group2) from North-West Region of Russia was studied by RLFP methods. Higher frequencies of T/C PPARD, Ser/Ser PGC-1 and C/C UCP3 genotypes in group1 compared to group2 were found. Furthermore, it was shown different distribution of PPARA, PPARD, PGC-1 and UCP2 genotypes in man and woman. We suggest that PPARA, PPARD, PGC-1 and UCP3 polymorphism is significant for survival.

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Irina V Tarkovskaia,Oleg S Glotov,Tatyana E Ivashchenko,Vladislav S Baranov. Analysis of UCPs, PPARs and PGC-1 gene polyorphism in elderly people from North-West region of Russia. Ecological Genetics, 2011, 9(4): 35-42 DOI:10.17816/ecogen9435-42