Effect of LIM kin ase 1 is oform ratio on Drosophil a mel anogaster courtship behavior: a complex approach

Abstract

LIMK1 - is the key enzyme of actin remodeling which controls dendritic spine morphology necessary for synaptic plasticity during learning and memory formation. Conditioned courtship suppression paradigm and a set-up for communicative sound production during courtship were used to asses learning acquisition and memory formation in four Drosophila strains polymorphic for the limk1 gene harbored by the agnostic locus: the wild type strains Canton-S, Berlin, Oregon-R and the mutant аgnts3. Behavioral performances were compared to the brain content and ratio of two LIMK1 isoforms in these Drosophila strains.

Keywords

limk1

References

[1] Лобашев М. Е., 1961. Сигнальная наследственность // Исследования по генетике. Л.: изд-во ЛГУ. Под редакциейМ. Е. Лобашева. Т. 1. С. 3-11.

[2] Медведева А. В., Молотков Д. А., Никитина Е. А., Попов А. А., Карагодин Д. А., Баричева Е. М., Савватеева-

[3] Попова Е. В. 2008. Системная регуляция генетических и цитогенетических процессов сигнальным каскадом ремо- делирования актина: локус agnostic дрозофилы // Генети- ка. Т. 44. № 6. С. 669-681.

[4] Попов А. В., Каминская А. Н., Савватеева-Попова Е. В., 2009. Поведение ухаживания, коммуникационное звуко- излучение и устойчивость к стрессу мутантов дрозофилы Drosophila melanogaster по гену agnostic, кодирующему LIMK1 // Журнал эволюционной биохимии и физиоло- гии. Т. 45. № 2. С. 184-190.

[5] Попов А. В., Переслени А. И., Комарова А. Ю., Савватеева-Попова Е. В., 2006. Устойчивость характе- ристик поведения ухаживания и коммуникационного звукоизлучения самцов Drosophila melanogaster к стрессорным воздействиям на разных стадиях онтоге- неза // Сенсорные системы. Т. 20. №2. С. 131-140.

[6] Попов А. В., Савватеева-Попова Е. В., Камышев Н. Г., 2000. Особенности акустической коммуникации у плодовых мушек Drosophila melanogaster // Сенсорные системы. Т. 14. С. 60-74.

[7] Bamburg J. R., Bloom G. S., 2009. Cytoskeletal pathologies of Alzheimer disease // Cell Motil Cytoskeleton. Vol. 66. № 8. P. 635-649.

[8] Bamburg J. R., Zheng J. Q., 2010. ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity // Nat Neurosci. Vol. 13. № 10. P. 1208-1215.

[9] Botella J. A., Bayersdorfer F., Gmeiner F., Schneuwly S., 2009. Modelling Parkinson's disease in Drosophila // Neuromolecular Med. Vol. 11. № 4. P. 268-80.

[10] Edwards D. C., Gill G. N., 1999. Structural features of LIM kinase that control effects on the actin cytoskeleton// J. Biol. Chem. Vol. 274. № 16. Р. 11352- 11361.

[11] Endo M., Ohashi K., Mizuno K., 2007. LIM kinase and slingshot are critical for neurite extension // J. Biol. Chem. Vol. 282. № 18. Р. 13692-13702.

[12] Ewing A. W., 1989. Arthropod bioacoustics: neurobiology and behavior // N. Y.: Cornel University Press.

[13] Gao J., Wang W. Y., Mao Y. W., Gräff J., Guan J. S., Pan L., Mak G., Kim D., Su S. C., Tsai L. H., 2010. A novel pathway regulates memory and plasticity via SIRT1 and miR-134 // Nature. Vol. 466. № 7310. P. 1105-1114.

[14] Kamyshev N. G., Iliadi K. G., Bragina J. V. 1999. Drosophila conditioned courtship: two ways of testing memory // Learn Mem. Vol. 6 № 1. P. 1-20.

[15] Maloney M. T., Bamburg J. R., 2007. Cofilin-mediated neurodegeneration in Alzheimer's disease and other amyloidopathies // Mol Neurobiol. Vol. 35. №1. P. 21-44.

[16] Masliah E., 2000. The role of synaptic proteins in Alzheimer's disease // Ann N Y Acad Sci. Vol. 924. P. 68-75.

[17] Medvedeva A. V., Zhuravlev A. V., Savvateeva-Popova E. V., 2010. LIMK1, the key enzyme of actin remodeling bridges spatial organization of nucleus and neural transmission: from heterochromatin via non-coding RNAs to complex behavior. In: Horizons in Neuroscience Research. Vol. 1. Ch. 4. P. 161-193.

[18] Moloney A., Sattelle D. B., Lomas D. A., Crowther D. C., 2010. Alzheimer's disease: insights from Drosophila melanogaster models // Trends Biochem Sci. Vol. 35. N 4. P. 228-235.

[19] Nagata K., Ohashi K., Yang N., Mizuno K., 1999. The Nterminal LIM domain negatively regulates the kinase activity of LIM-kinase 1 // Biochem. J. Vol. 343 Pt1. P. 99-105.

[20] Rincon-Limas D. E., Casas-Tinto S., Fernandez-Funez P., 2010. Exploring prion protein biology in flies: genetics and beyond // Prion. Vol. 4. № 1. Р. 1-8.

[21] Rusinov V., Baev V., Minkov I. N., Tabler M., 2005. MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence // Nucleic Acids Res. Vol. 33 (Web Server issue): W. 696-700.

[22] Schilcher F. von., 1976a. The role of auditory stimuli in the courtship of Drosophila melanogaster // Anim. Behav. Vol. 24. P. 18-26.

[23] Schilcher F. von., 1976b. The function of pulse song and sine song in courtship of Drosophila melanogaster // Anim. Behav. Vol. 24. P. 622-625.

[24] Schonrock N., Ke Y. D., Humphreys D., Staufenbiel M., Ittner L. M., Preiss T, Götz J., 2010. Neuronal micro RNA deregulation in response to Alzheimer's disease amyloid- beta // PLoS One. Vol. 5. №6. P. e11070.

[25] Schratt G. M., Tuebing F., Nigh E. A., Kane C. G., Sabatini M. E., Kiebler M., Greenberg M. E., 2006. A brain-specific microRNA regulates dendritic spine development // Nature. Vol. 439. №7074. P. 283-289.

[26] Siegel R. W., Hall J. C., 1979. Conditioned responses in courtship behavior of normal and mutant Drosophila // Proc. Natl. Acad. Sci. USA. Vol. 76. №1. P. 3430-3434.

[27] Yang C., Huang M., DeBiasio J., Pring M., Joyce M., Miki H., Takenawa T., Zigmond S. H., 2000. Profilin enhances Cdc42-induced nucleation of actin polymerization // J Cell Biol. Vol. 150. №5. P. 1001-1012.

[28] Yao Jiaqi, Hennessey Tom, Flynt Alex, Lai Eric, Beal M. Flint, Lin Michae T., 2010. MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease // PLoS ONE. Vol. 5. №12. P. 15546- 15554.

RIGHTS & PERMISSIONS

Kaminskaya A.N., Nikitina E.A., Payalina T.L., Molotkov D.A., Zakharov G.A., Popov A.V., Savvateeva-Popova E.V.