Geograpahic distribution of allele frequencies of alcohol metabolism genes and possible determinants of inter population diversity in human
Svetlana A Borinskaya , - - , Nina R Kalina , Vyacheslav I Shirmanov , Vladimir A Koshechkin , Nikolay K Yankovsky
Ecological Genetics ›› 2011, Vol. 9 ›› Issue (3) : 47 -56.
Geograpahic distribution of allele frequencies of alcohol metabolism genes and possible determinants of inter population diversity in human
ADH1B and ALDH2 genes are coding for key alcohol metabolism enzymes. Both allele ADH1B*Arg48His and ALDH2*504Lys are associated with lower alcohol consumption level. The allele frequencies were determined for rather few populations of Russia. The article presents аn updated review on the allele frequencies worldwide including the data for populations of Russia which were determined by our lab in recent years. Possible role of factors influencing the peculiarities of ADH1B*48His and ALDH2*504Lys allele frequencies geographic distribution are being discussed.
Borinskaya S.A., - -., Kalina N.R., Shirmanov V.I., Koshechkin V.A., Yankovsky N.K.
/
| 〈 |
|
〉 |
PDF
