EPIGENETIC ASPECTS OF ABNORMALITIES OF HUMAN EMBRYO DEVELOPMENT

Abstract

Early stages of human embryo development are characterized by an extremely high incidence of reproductive losses. Genomic mutations are the main contributing factor in this phenomenon. However, a significant part of miscarriages cannot explained by current genetic or cytogenetic concepts. A possible impact of abnormalities of the epigenetic genome organization into etiology of reproductive wastages is discussed in the current review. Characteristics of aberrant epigenetic modifications, ontogenetic and molecular mechanisms of their appearance are given in the light of genomic imprinting. 

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Lebedev I.N.