ASSOCIATION OF DNA REPAIR GENE POLYMORPHISM WITH CHROMOSOMAL ABERRATIONS IN THE HUMAN LYMPHOCYTES

Varvara I Minina; Vladimir G Druzhinin; Anna A Lunina; Aleksey V Larionov; Alexey N Volkov; Tatyana A Golovina; Andrey N Glushkov

doi:10.17816/ecogen9274-79

Ecological Genetics ›› 2011, Vol. 9 ›› Issue (2) :74 -79. DOI: 10.17816/ecogen9274-79

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ASSOCIATION OF DNA REPAIR GENE POLYMORPHISM WITH CHROMOSOMAL ABERRATIONS IN THE HUMAN LYMPHOCYTES

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Abstract

Analysis of association between several DNA repair gene polymorphisms and the level of chromosomal aberrations (CAs) in lymphocytes was performed in two groups of teenagers: a group of 256 donors exposed to indoor radon and a control group of 94 donors. In the group of children with living conditions exposing them to high doses of radon (> 200 Bq/m3 ), the level of CAs shows a significant increase in the carrier of genotypes: hOGG1 Cys/Cys, hOGG1 Ser/Cys, ADPRT Ala/Ala and ADPRT Val/Ala. Furthermore there were no significant associations between level of CA and Arg194Trp, Arg280His, Arg399Gln polymorphisms of the XRCC1 and Asp148Glu polymorphism of the APE1 found.

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APE1 / HOGG1 / ADPRT

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Varvara I Minina, Vladimir G Druzhinin, Anna A Lunina, Aleksey V Larionov, Alexey N Volkov, Tatyana A Golovina, Andrey N Glushkov. ASSOCIATION OF DNA REPAIR GENE POLYMORPHISM WITH CHROMOSOMAL ABERRATIONS IN THE HUMAN LYMPHOCYTES. Ecological Genetics, 2011, 9(2): 74-79 DOI:10.17816/ecogen9274-79

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