APOE gene ε4/ε4 “thrifty” genotype and risk of metabolic disorders in the Uralic peoples
Andrey I Kozlov , Svetlana A Borinskaya , Ekaterina D Sanina
Ecological Genetics ›› 2011, Vol. 9 ›› Issue (2) : 17 -23.
APOE gene ε4/ε4 “thrifty” genotype and risk of metabolic disorders in the Uralic peoples
The prevalence of APOE gene ε4/ε4 genotype in the populations with various level of “westernization” is under the consideration. It is proposed that the populations with a high frequency of *ε4 undergoing “modernization transition” are in the most vulnerable state. These are the Eastern Finns and especially indigenous people of the North, who have a higher level of diseases of circulatory system than megacity residents.
Kozlov A.I., Borinskaya S.A., Sanina E.D.
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