Epigenetical mechanisms of susceptibility to complex human diseases

Eugene L Patkin; John Quinn

doi:10.17816/ecogen8444-56

Ecological Genetics ›› 2010, Vol. 8 ›› Issue (4) : 44 -56. DOI: 10.17816/ecogen8444-56

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Epigenetical mechanisms of susceptibility to complex human diseases

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Abstract

Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.

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Eugene L Patkin,John Quinn. Epigenetical mechanisms of susceptibility to complex human diseases. Ecological Genetics, 2010, 8(4): 44-56 DOI:10.17816/ecogen8444-56