METABOLISM OF OSTEOTROPIC TOXICAL SUBSTANCES: HEREDITARY DETERMINATION

Abstract

 The hereditary component of the variability (intrafamily correlation) of the metabolism of osteotropic toxical substances — ⁹⁰Sr (a single injection) and stable fluorine (a chronic entering) were evaluated in laboratory linear mice in comparison with correlation of the morphological signs, hereditary of development of which is known. The evaluation was made with the control of the effects of sex, age and linear membership of animals and also taking into account the conditions of their development and the size of offspring. Significant intrafamily correlation of the concentration of ⁹⁰Sr and of fluorine in bone tissuewas revealed (r = 0,4–0,5; p < 0,0001). It can be compared with the correlation of morphological signs, which is the evidence of hereditary determinacy of the metabolism of osteotropic toxical substances.

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Starichenko V.I.