The frequencies of autoimmunity risk alleles of some genes in Belarus population
Elena A Aksenova , Tatiana N Pokladok , Dina V Boiko , Nina G Danilenko
Ecological Genetics ›› 2010, Vol. 8 ›› Issue (1) : 50 -58.
The frequencies of autoimmunity risk alleles of some genes in Belarus population
The population genotype and allele frequencies of +49A/G cytotoxic T-lymphocyte-associated antigen-4 (CTLA4); C1858T protein tyrosine phosphatase gene (PTPN22); –23HphIА/T insulin gene (INS) loci in native Belarusians from 6 ethnogeographic regions were estimated. The frequencies of risk allele homozygotes were: +49G CTLA4 — 17,3%; –23HphIА INS 50,7% — 1858Т PTPN22 — 4,1%. 5 individuals out of 662 investigated were risk homozygotes for all three genes, 21 were homozygotes with protective allele combination. The uniformity of genotypes and alleles distribution of investigated locuses across Belarus regions was demonstrated.
Aksenova E.A., Pokladok T.N., Boiko D.V., Danilenko N.G.
/
| 〈 |
|
〉 |
PDF
