Genotoxic effects of complex influence of radon and heavy metals depending on polymorphism of genes of enzymes monoxygenase systems
Varvara I Minina , Vladimir G Druzhinin , Andrey N Glushkov , Tatyana A Golovina , Svetlana V Apalko , Alexey N Volkov , Venera R Ahmatjanova , Anna A Lunina , Aleksey V Larionov
Ecological Genetics ›› 2009, Vol. 7 ›› Issue (3) : 53 -60.
Genotoxic effects of complex influence of radon and heavy metals depending on polymorphism of genes of enzymes monoxygenase systems
The correlation between genotype CYP1A and level of chromosomal aberrations in adolescents which are living and learning in a boarding school of Tashtagol of Kemerovskaya oblast' in the conditions of complex genotoxic influence of raised concentration of radon and heavy metals has been studied. The levels of chromosomal aberrations were increased in carriers of at least one CYP1A1 *2A allele, as compared with CYP1A1*1A*A gomozygotes. Frequency of ring chromosomes it is significant it is raised at donors of genotype CYP1A1 *1A*1A (T3801C). Frequency of occurrence of lural chromosomal aberrations it is significant it is raised at donors with genotype CYP1A2 *1A*1A. The conclusion about the important role of CYP1A in formation genotoxic effects of complex influence of adon and heavy metals is made.
Minina V.I., Druzhinin V.G., Glushkov A.N., Golovina T.A., Apalko S.V., Volkov A.N., Ahmatjanova V.R., Lunina A.A., Larionov A.V.
/
| 〈 |
|
〉 |
PDF
