Diludine and cerebrocrast as bioprotectors in the model test-systems in vivo
Natalia V Savina , Natalia V Nikitchenko , Olga V Dalivelya , Tatyana D Kuzhir , Egils Bisenieks , Gunars Duburs , Roza I Goncharova
Ecological Genetics ›› 2009, Vol. 7 ›› Issue (3) : 30 -43.
Diludine and cerebrocrast as bioprotectors in the model test-systems in vivo
An influence of two 1,4-dihydropyridine derivatives (diludine and cerebrocrast) on Drosophiladevelopment and germ cell mutability was studied. It was revealed the concentration range, within which the compounds manifest their bio-stimulating effects increasing individual survival by 50-80 % as well as the protective action against the alkylating agent ethyl methanesulfonate reducing the level of induced mutations by 30-50 %. The pattern and presumable mechanisms of the bioprotective action of these compounds are considered.
Savina N.V., Nikitchenko N.V., Dalivelya O.V., Kuzhir T.D., Bisenieks E., Duburs G., Goncharova R.I.
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