Genotoxic properties of hypoglycemic drugs (systematic review)

Natalia V. Eremina , Aliy K. Zhanataev , Artem A. Lisitsyn , Andrey D. Durnev

Ecological Genetics ›› 2021, Vol. 19 ›› Issue (3) : 219 -240.

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Ecological Genetics ›› 2021, Vol. 19 ›› Issue (3) : 219 -240. DOI: 10.17816/ecogen70691
Genetic toxicology
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Genotoxic properties of hypoglycemic drugs (systematic review)

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Abstract

According to the literature genotoxic properties of about a half of hypoglycemic drugs have not been investigated in accordance with the recommended methodology, and studies of the mutagen-modifying activity of antidiabetic drugs are sporadic. Based on the available published data, it is impossible to conclude about either presence or absence of genotoxic / antigenotoxic potential of antidiabetic drugs. There is evidence of the antimutagenic activity of metformin; in relation to other drugs, studies of mutagen-modifying activity have not been carried out or are represented only by a few articles. Further study of the genotoxic properties of hypoglycemic drugs is required in accordance with modern approaches and requirements, as well as an assessment of their mutagen-modifying activity.

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diabetes / chromosomal aberrations / micronuclei / DNA comet assay / DNA damage / genotoxicity / antigenotoxicity

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Natalia V. Eremina, Aliy K. Zhanataev, Artem A. Lisitsyn, Andrey D. Durnev. Genotoxic properties of hypoglycemic drugs (systematic review). Ecological Genetics, 2021, 19(3): 219-240 DOI:10.17816/ecogen70691

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