Genotoxicity of the pestiside in Ames test and the possibility to formate the complexeses with DNA
Elena A Saratovskikh , Vadim M Glazer , Natalya Yu Kostromina , Sergey V Kotelevtsev
Ecological Genetics ›› 2007, Vol. 5 ›› Issue (3) : 46 -54.
Genotoxicity of the pestiside in Ames test and the possibility to formate the complexeses with DNA
The Ames test (strains Salmonella typhimurium тА98 and тА100) was used to study mutagen activity of seven pesticides: six herbicides (roundup, zenkor basagran, kusagar, lontrel, setoxidim), and fungicide tachigaren, also as herbicide complexes lontrel with eight metals (Cu, Co, Zn, Ni, Fe, Мп, Mo, Mg). It is positioned, that mutagen indexes of the investigated pesticides correlate with the value constant of formation the complexes these substances with DNA. Complexes lontrel (ML<sub>2</sub>) with all metals have displayed mutagen activity. Genotoxicity NiL<sub>2</sub>, FeL<sub>2</sub>, ZnL<sub>2</sub> it is close to genotoxicity initial lontrel, at complexes with other metals have genotoxicity in 1,5-2 times lower.
Saratovskikh E.A., Glazer V.M., Kostromina N.Y., Kotelevtsev S.V.
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