Perspectives of micronuclear test in human lymphocytes cultivated in cytogenetic block conditions. Part 1: Cell proliferation

Abstract

Cultivation of human blood lymphocytes under the conditions of cytokinetic block with cytochalasin B creates unique opportunity to analyze the total spectrum of the changes describing genome instability. The main task of the present publication is the analysis of a modern state, opportunities and outlooks of the micronuclear test on human blood lymphocytes. The special attention is given those directions of researches which are rather seldom present in the literature - to laws of cellular proliferation, to existence of physiological conditionality and genetic predisposition to development of effects of genome instability; to effects of emotional stress and the adaptive response to action of ionizing irradiation, etc. The material is presented in 2 consecutive publications. It is finished with discussion of methodical features of statement of culture, results of the microscopic analysis and ideology of creation of the conclusions of the study.

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Ingel F.I.