Examination of the working environment genotoxic effects on the workers of a coal-fired power plant using the micronucleus test in blood lymphocytes

Abstract

BACKGROUND: The micronucleus test of peripheral blood lymphocytes provides a qualitative assessment of the state of the genome. A study was carried out aimed at studying the influence of factors of the working environment of coal-fired power plants on the state of the DNA of working data of enterprises.

MATERIALS AND METHODS: Using a micronucleus test with a cytochalasin block on human blood lymphocytes in vitro, 116 men were examined: 45 employees of the Novo-Kemerovo coal-fired power plant and 71 healthy residents of the Kemerovo region.

RESULTS: An increase in the frequency of occurrence of cells with micronuclei, bridges and protrusions in the blood lymphocytes of workers of a coal-fired power plant in comparison with healthy residents of the same area was found.

CONCLUSION: The data confirm the existing idea of the potential danger of combustion products for human health.

Keywords

micronuclear testing / blood lymphocytes / thermal power plants / occupational groups / genotoxicity

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Funding

РФФИ и Кемеровская областьRFBR and Kemerovo region(№ 20-44-420012)

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Fedoseev V.I., Stepanov D.D., Minina V.I.