Structure-activity relationships of antimutagenic flavonoids
Orkhan N Mustafaev , Serikbay K Abilev , Viktor A Melnik , Valentin A Tarasov
Ecological Genetics ›› 2005, Vol. 3 ›› Issue (4) : 11 -18.
Structure-activity relationships of antimutagenic flavonoids
Influence of structural features of molecules on antimutagenic activity of flavonoids is investigated. For this purpose the new principle of the description of dependence of biological activity of chemical compounds from their structure is used. It is based on use compound descriptors. It is established, that antimutagenic flavonoids contains C4 keto-group and doubl bond at positions C2 and C3, contains hydroxyl groups. Thus in structure of antimutagenic flavonoids can not be amino-and nitrogroups.
Mustafaev O.N., Abilev S.K., Melnik V.A., Tarasov V.A.
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