Adaptive role of tmRNA
Galina A Zhouravleva , Nikolay S Rovinski
Ecological Genetics ›› 2005, Vol. 3 ›› Issue (3) : 12 -18.
Adaptive role of tmRNA
тmRNA is a small RNA molecule, found only in bacteria, that exhibits properties of tRNA and mRNA. TmRNA involved in process of «trans-translation» when protein translates from two different RNA molecules and one of them is tmRNA. Its function is decreasing of translation error amount by releasing of stalled ribosomes and degradation of incorrect proteins.
| [1] |
Gillet R. Felden B. Emerging views on tmRNA-mediated protein tagging and ribosome rescue.//Molecular Microbiology. -2001. -Vol. 42. -P. 879-885. |
| [2] |
Haebel P.W., Gutmann S., Ban N. Dial tm for rescue: tmRNA engages ribosomes stalled on defective mRNAs.//Current Opinion in Structural Biology. -2004. -Vol. 14. -P. 58-65. |
| [3] |
Ibba M., Soll D. Quality control Mechanisms During Trans la tion.//Science. -1999. -Vol. 286. -P. 1893-1897. |
| [4] |
Jeffares D.C., Poole A.M., Penny, D. Relics from the RNA World.//J. Mol. Evol. -1998. -Vol. 46. -P. 18-36. |
| [5] |
Julio S.M., Heithoff D.M., Mahan M.J. ssrA (tmRNA) plays a role in Salmonella enterica Serovar Typhimurium pathogenesis.//J Bac te riol. -2000. -Vol. 182. -P. 1558-1563. |
| [6] |
Karzai A.W., Roshe E.D., Sauer R.T. The SsrA-SmpB system for protein tagging, directed degradation and ribosome rescue.//Nature structural biology. -2000. -Vol. 7, N 6 -P. 449-455. |
| [7] |
Keiler K.C., Waller P.R., Sauer R.T. Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA.//Science. -1996. -Vol. 271. -P. 990-993. |
| [8] |
Muto A., Ushida C., Himeno H. A bacterial RNA that functions as both a tRNA and an mRNA.//TIBS. -1998. -Vol. 23. -P. 25-29. |
| [9] |
Poole A.M., Jeffares D.C., Penny D. The Path from the RNA World.//J. Mol. Evol. -1998. -Vol. 46. -P. 1-17. |
| [10] |
Roshe E.D., Sauer R.T. Identification of Endogenous SsrA-tagged Proteins Reveals Tagging at Positions Corresponding to Stop Codons.//J. Biol. Chem. -2001. -Vol. 276. -P. 28509-28515. |
| [11] |
Vioque A., de la Cruz J. Trans-translation and protein syntesis inhibitors.//FEMS. -2003. -Vol. 218. -P. 9-14. |
| [12] |
Withey J.H., Friedman D.I. The biological roles of trans-translation.//Current Opinion in Structural Biology. -2002. -Vol. 5. -P. 154-159. |
| [13] |
Wower J., Wower I.K., Kraal B. et al. Quality Control of Elongation Step of Protein Synthesis by tmRNA.//Am. Soc. for Nutritional Sci. -2001. -P. 2978S-2982S. |
Zhouravleva G.A., Rovinski N.S.
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