Genotoxic biomarkers in patients on hemodialiasis
Natalia V. Eremina , Andrey D. Durnev
Ecological Genetics ›› 2020, Vol. 18 ›› Issue (3) : 367 -389.
Genotoxic biomarkers in patients on hemodialiasis
It is generally recognized that genotoxic damage have essential etiopathogenetic significance, and its prevention is an important measure to preserve human life and health. In the framework of this concept, literature information on studies of genotoxic biomarkers in patients with various hemodialysis regiments has been reviewed and summarized, and ways to prevent detectable genotoxicity have been identified. Based on the analysis of the known data, it was concluded that patients of this group have an increased level of DNA and chromosome damage in peripheral blood lymphocytes. Based on the results of individual studies, it was shown that one of the strategies for reducing genotoxicity may be the improvement of hemodialysis therapy methods and regimes, as well as pharmacological and nutritional correction of genotoxic effects.
hemodialysis / hemodiafiltration / genotoxicity / DNA damage / chromosomal aberrations / micronuclei
Eremina N.V., Durnev A.D.
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