Analysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people
Andrey S Glotov , Oleg S Glotov , Mikhail V Moskalenko , Viktor A Rogozkin , Tatyana E Ivashchenko , Vladislav S Baranov
Ecological Genetics ›› 2004, Vol. 2 ›› Issue (4) : 40 -43.
Analysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people
We analyzed AGT (M235T), ACE (I/D), AGTR1 (A1166C) genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people by PCR/RFLP methods. It was shown increasing of M/T genotype of AGT gene in rowers compared with population group (46 and 34%, accordantly), I/D of ACE (55 and 48%, accordantly) and decreasing of A/C genotype of AGTR1 gene (38 and 51%). It was detected significantly increasing of M/T genotype of AGT gene elderly people compared with population group (56 and 34%, accordantly, x2=l 1,828, p=0,0006). The received data allow to make the assumption of a possible role renin-angiotensine systems in process of ageing and active physical working capacitу
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Glotov A.S., Glotov O.S., Moskalenko M.V., Rogozkin V.A., Ivashchenko T.E., Baranov V.S.
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