DNA metylation as one of the main mechanisms of gene activity regulation
Anna A Pendina , Vera V Grinkevich , Tatyana V Kuznetsova , Vladislav S Baranov
Ecological Genetics ›› 2004, Vol. 2 ›› Issue (1) : 27 -37.
DNA metylation as one of the main mechanisms of gene activity regulation
DNA methylation is one of the main mechanisms of epigenetic inheritance in eukaryotes. In this review we looked through the ways of 5-methylcytosin origin, it's distribution in genome, the mechanism of gene repression via hypermetilation, the role of metylation in genomic imprinting and in X-chromosome inactivation, in embryogenesis of mammals, in the processes of oncogenesis and in etiology of some common human inherited diseases
Pendina A.A., Grinkevich V.V., Kuznetsova T.V., Baranov V.S.
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