Gene (CYP1A2, CYP2F1, NQO1, UGT2B7, CAT, GSTP1) - environment interactions analysis in occupational chronic bronchitis

Abstract

Background. Occupational chronic bronchitis is one of the common disease and both genetic and environmental risk factors contribute to its etiology. Materials and methods. A case-control study was conducted using 122 patients with occupational chronic bronchitis and 166 healthy workers to investigate the association of CYP1A2 (rs762551, rs35694136), CYP2F1 (rs11399890), NQO1 (rs1131341, rs1051740), UGT2B7 (rs7439366), CAT (rs1001179, rs769217), GSTP1 (rs1695, rs1138272) polymorphisms with the disease developing risk Analysis was performed to test for GxE interactions with exposures (smoking, PY, occupational experience) using logistic regression models. Results. It was shown CYP1A2 rs35694136 (P = 0.02, in over-dominant model), UGT2B7 rs7439366 (P = 0.002 in recessive model), CAT rs1001179 (P = 0.02, in dominant model) were significantly associated with high risk of occupational chronic bronchitis development. When ethnicity, smoking, PY, occupational experience were included in the logistic regression model, it was shown association with risk of disease development for rs1131341 NQO1 (Padj = 0.0004, ORadj = 3.57), rs7439366 UGT2B7 (Padj = 0.0024, ORadj = 2.31), rs35694136 CYP1A2 (Padj = 0.0041, ORadj = 2.17). Statistically significant interaction with smoking status was defined for rs7439366 UGT2B7 (Pinteract = 0.015, in over-dominant model) with PY-for rs11399890 CYP2F1 (Pinteract = 0.05 in additive model). Conclusion. Identifying GxE interaction will lead to better understanding of the development of occupational chronic bronchitis and potential biological mechanisms, and, in future, effective prevention strategies.

Keywords

occupational chronic bronchitis / gene-environment interactions / polymorphisms / xenobiotics biotransformation and antioxidant protection genes

RIGHTS & PERMISSIONS

Akhmadishina L.Z., Korytina G.F., Kochetova O.V., Viktorova T.V.