Influence of DNA repair genes polymorphism on karyology of buccal epithelium cells in humans exposed to radon
Alina Viktorovna Meyer , Tatyana Andreyevna Tolochko , Varvara Ivanovna Minina , Anna Aleksandrovna Timofeyeva
Ecological Genetics ›› 2014, Vol. 12 ›› Issue (1) : 28 -38.
Influence of DNA repair genes polymorphism on karyology of buccal epithelium cells in humans exposed to radon
Were investigated samples from 318 children and adolescents (174 males, 144 females), who were exposed to radon at home, and 65 people (23 males, 42 females) in the control group. Using micronucleus test on buccal epithelial cells we identified a significant increase in the number of cells with cytogenetic and proliferative abnormalities in the exposed group. Were investigated the association NBS1 (rs1805794), ATM (rs1801516), ADPRT (rs1136410) genes polymorphism with karyological abnormalities in buccal epithelial cells. For the exposed group, an association of NBS1 Glu185Gln polymorphism with increasing frequency of identification of “broken egg”-type protrusions and apoptotic bodies was established. NBS1 185Glu/Gln & ATM1853Asp/Asp genotypes were associated with an elevated levels of cytogenetic damage, while the NBS1 185Glu/Glu & ATM 1853Asp/Asn allelic variant plays a protective role. In the control group, no significant associations were found.
micronucleus test / buccal epithelial cells / ionizing radiation / radon / DNA repair genes
Meyer A.V., Tolochko T.A., Minina V.I., Timofeyeva A.A.
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