Reducing of LXRβ and PPARγ mRNA in M-CSF stimulated macrophages in patients with levels atherosclerosis
Yekaterina Petrovna Demina , Valentina Vadimovna Miroshnikova , Nikolay Vladimirovich Mayorov , Vladimir Valentinovich Davydenko , Alexander L`vovich Schwarzman
Ecological Genetics ›› 2014, Vol. 12 ›› Issue (1) : 14 -18.
Reducing of LXRβ and PPARγ mRNA in M-CSF stimulated macrophages in patients with levels atherosclerosis
Nuclear receptors LXRα/β and PPARγ play an important role in lipid metabolism and reverse cholesterol transport. However, the influence of LXRα/β and PPARγ mRNA levels in macrophages on atherosclerosis remains unexplored. Using real time PCR, we determined LXRα mRNA, LXRβ mRNA and PPARγ mRNA levels in macrophages cultured for 5 days with macrophage colony-stimulating factor (M-CSF). Levels of LXRβ mRNA and PPARγ mRNA in patients with arterial stenosis were reduced when compared with the control group, p < 0.001. LXRa gene mRNA level in macrophages was not changed in the study groups, (p = 0.17). Thus, our study shows that the LXRβ and PPARγ genes expression levels in macrophages may be significant factors associated with the development of atherosclerosis.
artery stenosis / atherosclerosis / LXRα/β genes / macrophages / PPARγ gene
Demina Y.P., Miroshnikova V.V., Mayorov N.V., Davydenko V.V., Schwarzman A.L.
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