Association of vitamin D receptor gene with anthropometric measures in komi ethnic group

Abstract

The relationship between vitamin D receptor gene (VDR) variants with serum 25-OHD3 concentration, body height (BH), body weight (BW), and body composition were examined in Komi ethnic group. The FF genotype associates with higher BW (p=0.002), and lower bone mass (BM, p=0.06) in comparison with the Ff subjects. The BB carriers are shorter than those with Bb genotype (p=0.037); BM is lower among having bb than Bb variants (p=0.025). There were no differences in 25-OHD3 content revealed. The results are consistent with the data obtained in populations from North-Western Europe, but not in tropical and subtropical Caucasians, or in non-Caucasian groups.

Keywords

VDR / FokI / BsmI / ApaI / TaqαI / 25-OHD3 / VDR / FokI / BsmI / ApaI / TaqαI / 25-hydroxyvitamin D3 / 25-OHD3 / body height / body mass / body composition / fat tissue / bone tissue / muscle tissue

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