Research of genetic markers in susceptibility to arterial hypertension in Russian Northwest region children
Mariya Dmitriyevna Kanayeva , Andrey Sergeyevich Glotov , Yelena Sergeyevna Vashukova , Galina Igorevna Obraztsova , Vladislav Sergeyevich Baranov
Ecological Genetics ›› 2013, Vol. 11 ›› Issue (2) : 34 -40.
Research of genetic markers in susceptibility to arterial hypertension in Russian Northwest region children
Вy PCR-RFLP procedures in groups of children of the Northwest region of Russia we investigated associations of some variants of CYP2J2, CYP4A11 and PTGIS genes participating in a metabolism of arachidonic acid and variants of CDH13, MTHFR, CDKN2BAS genes, and also an extra gene molecular marker rs11191548 T/C revealed on the basis of the GWAS method as candidates of risk of arterial hypertension, with development of a hypertension. The association of these markers with development of a hypertension in children didn't prove to be true.
association / gene polymorphism / children / arterial hypertension / metabolism of arachidonic acid / genome-wide association study (GWAS)
Kanayeva M.D., Glotov A.S., Vashukova Y.S., Obraztsova G.I., Baranov V.S.
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