Research of genetic markers in susceptibility to arterial hypertension in Russian Northwest region children

Mariya Dmitriyevna Kanayeva; Andrey Sergeyevich Glotov; Yelena Sergeyevna Vashukova; Galina Igorevna Obraztsova; Vladislav Sergeyevich Baranov

doi:10.17816/ecogen11234-40

Ecological Genetics ›› 2013, Vol. 11 ›› Issue (2) :34 -40. DOI: 10.17816/ecogen11234-40

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Research of genetic markers in susceptibility to arterial hypertension in Russian Northwest region children

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Abstract

Вy PCR-RFLP procedures in groups of children of the Northwest region of Russia we investigated associations of some variants of CYP2J2, CYP4A11 and PTGIS genes participating in a metabolism of arachidonic acid and variants of CDH13, MTHFR, CDKN2BAS genes, and also an extra gene molecular marker rs11191548 T/C revealed on the basis of the GWAS method as candidates of risk of arterial hypertension, with development of a hypertension. The association of these markers with development of a hypertension in children didn't prove to be true.

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association / gene polymorphism / children / arterial hypertension / metabolism of arachidonic acid / genome-wide association study (GWAS)

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Mariya Dmitriyevna Kanayeva, Andrey Sergeyevich Glotov, Yelena Sergeyevna Vashukova, Galina Igorevna Obraztsova, Vladislav Sergeyevich Baranov. Research of genetic markers in susceptibility to arterial hypertension in Russian Northwest region children. Ecological Genetics, 2013, 11(2): 34-40 DOI:10.17816/ecogen11234-40