Research of the influence of LIG4 gene polimorphism on chromosomal aberrations level in human lymphocytes, with background and excessive exposure to radon
Aleksey Nikolayevich Volkov , Tatyana Aleksandrovna Golovina , Vladimir Gennadyevich Druzhinin , Aleksey Viktorovich Larionov , Varvara Ivanovna Minina , Anna Aleksandrovna Timofeyeva
Ecological Genetics ›› 2013, Vol. 11 ›› Issue (2) : 16 -21.
Research of the influence of LIG4 gene polimorphism on chromosomal aberrations level in human lymphocytes, with background and excessive exposure to radon
Effects of the LIG4 gene polymorphisms rs1805388 (Thr9Ile) and rs1805389 (Ala3Val) on the level of chromosomal aberrations in peripheral blood lymphocytes have been estimated in children, that live and study in conditions of normal and excessive exposure to radon in several localitions of the Kemerovo region. There was no statistically significant difference between genotypic groups on the marker rs1805388 with regard to frequencies of cytogenetic indexes. At the same time, in the group of Val carriers (marker rs1805389) from second cohort our analysis revealed significant increase in the amount of paired fragments in comparison with homozygotes Ala/Ala.
LIG4 / radon / chromosomal aberrations / genetic polymorphism / DNA repair genes / LIG4
Volkov A.N., Golovina T.A., Druzhinin V.G., Larionov A.V., Minina V.I., Timofeyeva A.A.
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