Overexpression of genes encoding asparagine-glutamine rich transcriptional factors causes nonsense suppression in Saccharomyces cerevisiae

Anton Aleksandrovich Nizhnikov; Aleksandra Mikhaylovna Kondrashkina; Kirill Sergeyevich Antonets; Aleksey Petrovich Galkin

doi:10.17816/ecogen11149-58

Ecological Genetics ›› 2013, Vol. 11 ›› Issue (1) : 49 -58. DOI: 10.17816/ecogen11149-58

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Overexpression of genes encoding asparagine-glutamine rich transcriptional factors causes nonsense suppression in Saccharomyces cerevisiae

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Abstract

Previously, we have carried out a search for genes, whose overexpression causes nonsense suppression on the background of modified SUP35 variants expression in yeast Saccharomyces cerevisiae. Here we analyzed the influence of genes encoding N/Q-rich transcriptional factors on this process. We demonstrated that GLN3, MCM1, MOT3 and REB1 genes overexpression affects nonsense suppression in S. cerevisiae

Keywords

amyloid / nonsense suppression / prion / yeast / translation termination

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Anton Aleksandrovich Nizhnikov, Aleksandra Mikhaylovna Kondrashkina, Kirill Sergeyevich Antonets, Aleksey Petrovich Galkin. Overexpression of genes encoding asparagine-glutamine rich transcriptional factors causes nonsense suppression in Saccharomyces cerevisiae. Ecological Genetics, 2013, 11(1): 49-58 DOI:10.17816/ecogen11149-58