A study of genetic markers of human height
Andrey S Glotov , Elena S Vashukova , Oleg S Glotov , Roman V Kurilov , Irina V Tarkovskaia , Ekaterina Y Ditkina , Irina V Pugacheva , Olga L Belonog , Irina A Makhrova , Vladimir S Pakin , Mikhail V Aseev , Tatyana E Ivashchenko
Ecological Genetics ›› 2012, Vol. 10 ›› Issue (4) : 77 -84.
A study of genetic markers of human height
A population study of polymorphisms of EFEMP1, ZBTB38, HHIP, LCORL, ADAMTSL3, CDH13, JAZF1, IGF1R, GHSR, CABLES1, IFNG, VDR3, and IGFBP3 genes, which possibly influence human height, was carried out using PCR-RFLP. Population frequencies of alleles and genotypes for these genes were established. A correlation between the rs572169 variant of GSHR gene and male height was found . We suggest a model for prediction of human height on the basis of logistic regression method. The obtained data indicate a possibility to assess human height on the basis of genetic markers.
| [1] |
Аульченко Ю. С., 2010. Разработка и применение методов полногеномного анализа генетических ассоциаций сложных признаков: Докт. дис. Новосибирск, 291 c. |
| [2] |
Баранов В. С., 2009. Генетический паспорт — основа индивидуальной и предиктивной медицины. СПб: Изд-во Н-Л. 528 с. |
| [3] |
Инге-Вечтомов С. Г., 2010. Генетика с основами селекции. СПб.: Изд-во Н-Л. 720 с. |
| [4] |
Маниатис Т., Фрич Э., Сэмбрук Д., 1984. Молекулярное клонирование. М.: Мир. 480 с. |
| [5] |
Budowle B., van Daal A., 2008. Forensically relevant SNP classes // BioTechniques 25th Anniversary. Vol. 44. N 5. P. 603–610. |
| [6] |
Gudbjartsson D., Walters G., Thorleifsson G. et al., 2008. Many sequence variants affecting diversity of adult human height // Nat. Genet. Vol. 40. P. 609–615. |
| [7] |
Lettre G., Jackson A., Gieger C. et al., 2008. Identification of ten loci associated with height highlights new biological pathways in human growth // Nat. Genet. Vol. 40. P. 584–591. |
| [8] |
Liu F., van Duijn K., Vingerling J. R. et al., 2010. Eye color and the prediction of complex phenotypes from genotypes // Current Biology. Vol. 19. N 5. P. 192–193. |
| [9] |
McCullagh P., Nelder J., 1989. Generalized Linear Models. Second Edition. — Chapman & Hall / CRC. 512 P. |
| [10] |
Pritchard J. K., 2001. Are rare variants responsible for susceptibility to complex disease? // Am. J. Hum. Genet. Vol. 69. P. 124–137. |
| [11] |
Reich D. E., Lander E. S., 2001. On the allelic spectrum of human disease // Trends Genet. Vol. 17. N 9. P. 502–510. |
| [12] |
Riedl S., Hughes I., Harris M. et al., 2012. GH secretagogue receptor gene polymorphisms are associated with stature throughout childhood // Eur. J. Endocrinol. Vol. 166. N 6. P. 1079–1085. |
| [13] |
Sanna S., Jackson A. U., Nagaraja R. et al., 2008. Common variants in the GDF5-UQCC region are associated with variation in human height // Nat. Genet. Vol. 40. P. 198–203. |
| [14] |
URL: http://www.ncbi.nlm.nih.gov/gene/1056 (дата обращения: 15.09.2012). |
| [15] |
URL: http://www.R — project.org. Development Core Team (Виртуальная среда для компьютеризованной статистики). Дата обращения: 15.09.2012. |
| [16] |
Weedon M. N., Lango H., Lindgren C. M. et al., 2008. Genome-wide association analysis identifies 20 loci that influence adult height // Nat. Genet. Vol. 40. N 5. P. 575–583. |
| [17] |
Wright A. F., Hastie N. D., 2001. Complex genetic diseases: controversy over the Croesus code // Genome Biol. Vol. 8. N 2. Comment 2007.1–comment 2007.8. |
| [18] |
Xu S., Hu Z., 2010. Generalized Linear Model for Interval Mapping of Quantitative Trait Loci // Theor. Appl. Genet. Vol. 121. N 1. P. 47–63. |
Glotov A.S., Vashukova E.S., Glotov O.S., Kurilov R.V., Tarkovskaia I.V., Ditkina E.Y., Pugacheva I.V., Belonog O.L., Makhrova I.A., Pakin V.S., Aseev M.V., Ivashchenko T.E.
/
| 〈 |
|
〉 |