Genes and enzymes of metabolic activation of xenobiotics in chemical carcinogenesis

Abstract

In the initial stage of chemical carcinogenesis the primary key event is metabolic activation of exogenic carcinogenic substances. The main enzymes of carcinogen's biotransformation (microsomal hydroxylation, reactions of conjugation) and genes which controlling the activity of these enzymes, has been characterized. The tissue(organ)specificity of expression of gene products (isoforms of su-perfamilies of CYPs and GSTs, family of NATs) as well as genetic polymorphism of enzymes involving into the biotransformation of carcinogenic xenobiotics were demonstrated

Keywords

CYPS / GSTS / NATS / AHR

RIGHTS & PERMISSIONS

Khudolei V.V.