Response of immunocompetent cells of bone marrow and spleen of mouse males of several strains to stress and to pyrazine containing chemosignals
Eugene V Daev , Boris P Surinov , Anna V Dukelskaya
Ecological Genetics ›› 2012, Vol. 10 ›› Issue (2) : 14 -20.
Response of immunocompetent cells of bone marrow and spleen of mouse males of several strains to stress and to pyrazine containing chemosignals
The quantity of antibody producing cells and mitotic disturbances in dividing bone marrow cells of mice were studied after exposure of animals to a physical stressor or various pyrazinecontaining chemosignals. Several different strains of mice were used. We demonstrate that immune suppression and destabilization of the chromosome apparatus in dividing cells depend on: а) mouse genotype and b) side chains position in the pyrazine ring. Importance of this effects in the light of wide usage of pyrazine containing substances in perfume industry, food production and pharmacology is discussed.
Daev E.V., Surinov B.P., Dukelskaya A.V.
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