Neuron-specific enolase as a prognosticator in cardiac arrest patients: key considerations

Raghuraman M Sethuraman

Emergency and Critical Care Medicine ›› 2026, Vol. 6 ›› Issue (2) : 84 -85.

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Emergency and Critical Care Medicine ›› 2026, Vol. 6 ›› Issue (2) :84 -85. DOI: 10.1097/EC9.0000000000000167
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Neuron-specific enolase as a prognosticator in cardiac arrest patients: key considerations
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Raghuraman M Sethuraman. Neuron-specific enolase as a prognosticator in cardiac arrest patients: key considerations. Emergency and Critical Care Medicine, 2026, 6 (2) : 84-85 DOI:10.1097/EC9.0000000000000167

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Conflict of interest statement

The author declares no conflict of interest.

Author contributions

Sethuraman RM wrote, reviewed, and edited the paper.

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References

[1]

Sierakowska A, Niewiadomska E, Łabuda S, Bieniasiewicz A, Roszak M, Łabuz-Roszak B . Neuron-specific enolase as a biomarker for selected neurological and psychiatric disorders-a systematic review of the literature. Medicina (Kaunas). 2025; 61(10): 1831. doi: 10.3390/medicina61101831.

[2]

Obling LER, Beske RP, Meyer MAS, et al. Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial. Intensive Care Med. 2023; 49(12): 1467-1478. doi: 10.1007/s00134-023-07247-w.

[3]

Müller J, Bissmann B, Becker C, et al. Neuron-specific enolase (NSE) predicts long-term mortality in adult patients after cardiac arrest: results from a prospective trial. Medicines (Basel). 2021; 8(11): 72. doi: 10.3390/medicines8110072.

[4]

Streitberger KJ, Leithner C, Wattenberg M, et al. Neuron-specific enolase predicts poor outcome after cardiac arrest and targeted temperature management: a multicenter study on 1,053 patients. Crit Care Med. 2017; 45(7): 1145-1151. doi: 10.1097/CCM.0000000000002335.

[5]

Nolan JP, Sandroni C, Böttiger BW, et al. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021; 47(4): 369-421. doi: 10.1007/s00134-021-06368-4.

[6]

Kim YJ, Kim YH, Youn CS, et al. Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry). Crit Care. 2023; 27(1): 313. doi: 10.1186/s13054-023-04603-6.

[7]

Vondrakova D, Kruger A, Janotka M, et al. Association of neuron-specific enolase values with outcomes in cardiac arrest survivors is dependent on the time of sample collection. Crit Care. 2017; 21(1): 172. doi: 10.1186/s13054-017-1766-2.

[8]

Chung-Esaki HM, Mui G, Mlynash M, Eyngorn I, Catabay K, Hirsch KG . The neuron specific enolase (NSE) ratio offers benefits over absolute value thresholds in post-cardiac arrest coma prognosis. J Clin Neurosci. 2018; 57: 99-104. doi: 10.1016/j.jocn.2018.08.020.

[9]

Babkina AS, Lyubomudrov MA, Golubev MA, Pisarev MV, Golubev AM . Neuron-specific enolase-what are we measuring?. Int J Mol Sci. 2024; 25(9): 5040. doi: 10.3390/ijms25095040.

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